中药贴敷联合按摩足三里治疗ICU患者热秘60例疗效观察

目的:观察中药贴敷联合按摩足三里治疗ICU患者热秘的临床疗效。方法:对60例ICU患者热秘给予神阙穴中药(大黄、白醋)贴敷,每日1次,每次8小时,足三里穴位按摩每日2次,每次15min,治疗3天后观察患者热秘症状及改善情况。结果:60例患者中治愈41例,显效11例,有效7例,无效1例,治愈率为68.3%,总有效率为98.3%。结论:中药贴敷神阙穴联合按摩足三里治疗ICU患者热秘是一种简单而有效的方法。     

PAT tools for the control of co-extrusion implants manufacturing process

Hot melt extrusion is a novel pharmaceutical manufacturing process technique. In this study, we identified four Critical Quality Attributes (CQAs) of the implant manufacturing process by hot melt extrusion: the implant diameter, the quantity of the Active Pharmaceutical Ingredient (API), the homogeneity distribution of API and the thickness of the membrane. We controlled the implant diameter and the quantity of API in-line with a laser measurement, NIR and Raman spectroscopy, respectively. These two different spectroscopic techniques provided comparable results. In fact, the RMSEC and RMSECV were very close in each PAT technique but NIR spectroscopy was easier to use and less sensitive to external changes. For the control of the homogeneity of API distribution and the thickness of the membrane, we used successfully Raman spectroscopy imaging. These PAT tools help reducing analysis time.     

Hot flashes and blood pressure in midlife women

Objectives

Recent epidemiological studies suggest that hot flashes may have a detrimental impact on the cardiovascular system. The purpose of this study was to examine the associations between hot flashes and blood pressure among women aged 45–54 years who had never used hormone therapy.

Study design

Data were analyzed from 603 women who participated in the Midlife Health Study, a cross-sectional study conducted in the Baltimore Metropolitan region.

Main outcome measures

All participants came to the clinic where systolic and diastolic blood pressures were measured, height and weight were assessed, and a questionnaire was administered that ascertained detailed data on history of hot flashes and participant demographics and health habits.

Results

The data showed that 56.9% of the participants reported ever experiencing hot flashes. In the age-adjusted analyses, both systolic and diastolic blood pressures were significantly and positively associated with hot flashes. However, the estimates were markedly attenuated and not statistically significant after adjustment for age, race, smoking status, current alcohol use, body mass index, and use of an anti-hypertensive agent or a cholesterol-lowering medication. Similar results were observed for moderate or severe hot flashes, hot flashes experienced for one or more years, and hot flashes experienced within the previous 30 days.

Conclusions

These findings indicate that hot flashes are not significantly associated with blood pressure during midlife.     

Granulocyte-colony stimulating factor (G-CSF) induces mechanical hyperalgesia via spinal activation of MAP kinases and PI3K in mice

Granulocyte-colony stimulating factor (G-CSF) is a current pharmacological approach to increase peripheral neutrophil counts after anti-tumor therapies. Pain is most relevant side effect of G-CSF in healthy volunteers and cancer patients. Therefore, the mechanisms of G-CSF-induced hyperalgesia were investigated focusing on the role of spinal mitogen-activated protein (MAP) kinases ERK (extracellular signal-regulated kinase), JNK (Jun N-terminal Kinase) and p38, and PI₃K (phosphatidylinositol 3-kinase). G-CSF induced dose (30-300 ng/paw)-dependent mechanical hyperalgesia, which was inhibited by local post-treatment with morphine. This effect of morphine was reversed by naloxone (opioid receptor antagonist). Furthermore, G-CSF-induced hyperalgesia was inhibited in a dose-dependent manner by intrathecal pre-treatment with ERK (PD98059), JNK (SB600125), p38 (SB202190) or PI₃K (wortmanin) inhibitors. The co-treatment with MAP kinase and PI₃K inhibitors, at doses that were ineffective as single treatment, significantly inhibited G-CSF-induced hyperalgesia. Concluding, in addition to systemic opioids, peripheral opioids as well as spinal treatment with MAP kinases and PI₃K inhibitors also reduce G-CSF-induced pain.     

对实施国家基本药物制度的热点与难点的认识和体会

目的:对推进基本药物制度的实施提供参考.方法:总结对实施基本药物制度的热点和难点的认识和体会,分析基本药物制度实施的成效和遇到的困难.结果与结论:我国开展实施国家基本药物制度工作以来,成绩斐然,政府各部门积极配合,出台了一系列方针政策,并落实了责任制度,在经济方面、医疗保障方面和机构建设等方面都有了显著改善.但实施过程...     

空气源热泵辅助太阳能系统在住院部大楼中的应用

本文以山东省中医院中医临床研究基地建设项目为例,对空气源热泵辅助太阳能制备热水系统设计的思路和过程进行简要介绍,探讨了建筑生活热水的节能系统形式。     

上善若水 下愚如火——刘完素著作中蕴涵的心理学思想

＂致知在格物,物格而后知至＂,刘完素的医学哲学思想吸收了这些积极的认识论成果。其学术思想除受到《素问》＂病机十九条＂中有关火热论述的启发外,还源于道家思想形成的＂水善火恶＂的自然观。刘完素在其著述中说：＂夫水数一,道近而善;火数二,道远而恶＂。水清明而火昏浊,故＂上善若水,下愚如火＂。＂火上有水制之,则为‘既济’;水在火下,不能制火,为‘未济’也。是故知水善火恶也。＂刘完素在阐发《素问》＂病机十九条＂时,用阴阳五行学说中＂亢害承制＂理论,详尽地描述了异常的心身现象,扩大了对心理病机的论述,从而发展了心理疾病的论治。     

视觉电生理检查对白内障术后视功能预测的评价

目的:探讨白内障超声乳化手术前行闪光视网膜电流图(F-ERG)和闪光视诱发电位(F-VEP)检查对术后视力预测的可靠性。方法:分析137眼白内障患者术前做F-ERG和F-VEP检查与术后视力的关系。结果:视觉电生理检查的符合率达90.8%。结论:F-ERG和F-VEP对白内障术后的视功能预测客观、有效。     

辣椒油中过氧化值测定方法的探讨分析

目的本文运用活性碳吸附前处理方法,解决国家标准方法[1]测定辣椒油中的过氧化值时,由于辣椒油中的色素存在而影响滴定终点的判断问题。方法利用活性碳吸附法前处理辣椒油样品后再按照国标法测定过氧化值,其结果与准确度和精密度都较高的自动电位滴定法相比较。结果用活性碳吸附法处理样品后再滴定可以清晰观察到滴定终点;辣椒油试样量在2～3g,用活性碳吸附法与自动电位滴定法结果无统计学差异,结果准确,精密度达到检验要求。结论对于深色油脂如辣椒油中的过氧化值测定首选自动电位滴定法,如没有自动电位滴定仪的基层单位,可以用活性碳吸附前处理方法。活性碳吸附法可以作为国标法测定辣椒油中过氧化值的有效补充。     

活络通中药温泉浸浴治疗踝关节急性软组织损伤的临床研究

目的 探讨活络通中药温泉浸浴治疗踝关节急性软组织损伤的临床疗效。方法 以活络通温泉中药浴治疗踝关节急性软组织损伤患者140例（治疗组）,并与正红花油加温泉浸浴治疗的患者140例（对照组）进行临床疗效对比,观察踝关节损伤局部疼痛、肿胀、瘀斑、功能障碍等治疗前后的变化,并量化积分。结果 治疗组愈显率89.29%,总有效率100%;对照组愈显率62.85%,总有效率92.14%,治疗组疗效明显优于对照组,两组间差异有统计学意义（P〈0.05）。治疗组在改善临床症状（疼痛、功能障碍）方面明显优于对照组（P〈0.05）。结论 活络通中药温泉浸浴治疗急性软组织损伤疗效显著。