广州地区功能性消化不良的中医证型分布特点及相关性研究

【目的】探讨广州地区功能性消化不良(FD)患者的中医证型分布特点及其相关性。【方法】选取在广州地区诊断为FD的326例患者进行中医证型的调查,将所得数据建立数据库,进行统计分析。【结果】326例广州地区FD患者的中医证型分别为脾虚气滞证占41.71%、肝胃不和证占26.07%、脾胃湿热证占11.96%、脾胃虚寒证占11.04%、寒热错杂证占9.20%,证型分布差异有统计学意义(P0.05)。各中医证型间的发病平均年龄和在广州居住时间比较,差异均有统计学意义(P0.05)。不同中医证型间的西医亚型与幽门螺杆菌(Hp)感染情况比较,差异均有统计学意义(P0.05)。【结论】广州地区功能性消化不良中医证候分布具有地域性,与居住广州年限、性别、年龄、西医亚型、Hp感染状况等具有相关性。     

广州市高校大学生生存质量及其影响因素研究

目的调查广州大学生生存质量及影响因素。方法采用整群抽样法,抽取广州市8所大学在校学生1000名,进行问卷调查。结果广州大学生生活质量属于中等,大学生对环境方面的适应相对较差;影响大学生生存质量的相关因素较多。结论广州大学生生存质量4个领域得分情况均呈近似正态分布,学校应通过改善大学生学习、生活条件,探索大学生生存质量有效途径。     

广州中医药大学计算机基础教学改革思路

面对日新月异的计算机技术及信息时代的到来,医学院校的每一个学生都必须掌握计算机的基本技能。因而,我校计算机基础教学再也不能"以不变应万变",而必须体现现代教学理论,以提高医学生计算机应用能力和文化素质为出发点,为学生今后的学习和工作打好基础。作为一个一直在教学第一线的教师,笔者认为应从以下几个方面进行改革,以适应不断变化的形势需要。     

Population Pharmacokinetic Analysis of Mizoribine in Chinese Renal Transplant Recipients

Background

We calculated the population pharmacokinetics of mizoribine in adult Chinese patients and compared the parameters with those of Japanese patients to determine whether there are any ethnic differences in blood concentration transition between these 2 populations.

Wheezing in Chinese schoolchildren: disease severity distribution and management practices, a community-based study in Hong Kong and Guangzhou

BACKGROUND: Asthma is a common chronic disease and information on its management practices at the community level is helpful in identifying problems and improving asthma care. OBJECTIVE: To assess the severity status and management of the asthma symptom of wheeze of children at the community level in Hong Kong (HK) and Guangzhou (GZ). METHODS: Cross-sectional study of children aged 10 years using the International Study of Asthma and Allergic disease in Childhood (ISAAC Phase II protocol). Asthma management and lung function were assessed in 178 (98 from HK and 80 from GZ) randomly selected children with wheeze over the past 12 months. RESULTS: Eighty-three percent, 11%, 6% and 0% of children suffered from intermittent, mild persistent, moderate persistent and severe persistent asthma, respectively, according to the frequency of their symptoms. Addition of spirometric parameter only changed the asthma severity classification in 2.8% of children. Medications were used by 30.6% and 71.3% of children for wheeze in HK and GZ, respectively. In HK, inhaled beta(2)-agonist (73.3% among the drug users) was the commonest medication used followed by inhaled corticosteroid (ICS) (23.3%). In GZ, inhaled beta(2)-agonist was used by 75.4% of children, but use of ICS (26.3%), oral beta(2)-agonist (26.3%), oral theophylline (45.6%), oral ketotifen (36.8%) and oral steroid (35.1%) were also common. ICS was only used by 11.4% of children with persistent asthma. Ten percent and 18.7% of children in HK and GZ, respectively, had emergency department visits, while 16.3% and 11.6% of children in HK and GZ, respectively, had missed school secondary to asthma over the past 1 year. CONCLUSIONS: Most children in the community had intermittent asthma and addition of lung function to symptoms did not significantly affect classification of asthma severity. Significant morbidity was seen even in this group of children with mostly intermittent and mild persistent asthma.     

广州地区6493例女性生殖道人乳头状瘤病毒检测结果分析

目的了解广州地区妇女生殖道人乳头状瘤病毒感染状况和基因亚型分布。方法 2006年10月至2010年2月,采用核酸分子快速导流杂交基因芯片分型技术(HybriMax)对广州地区6493例女性进行人乳头状瘤病毒检测,并对HPVDNA亚型、感染率和年龄分布进行分析。结果 6493例女性中检出HPV阳性1947例,阳性率为29.99%。阳性感染者中,单一型感染最多,为1436例,占73.75%,其中高危单一型感染者1143例,占58.71%,低危单一型感染者293例,占15.05%;混合型感染者511例,占26.25%,主要为双重感染,占19.41%。15个与宫颈癌密切相关的HPV高危亚型阳性率为25.24%,6个低危亚型HPV感染阳性率为7.98%。排在前十位的亚型分别是HPV52(25.22%)、HPV58(14.20%)、HPV16(13.56%)、HPV6(9.76%)、HPV11(8.32%)、HPV53(7.70%)、HPV33(6.73%)、CP8304(6.68)、HPV68(6.63)、HPV18(6.52%)。在各年龄组中,小于20岁女性感染率最高,为52.5%,各年龄组HPV感染差异有统计学意义...     

Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population

The purpose of this study was to investigate the genetic polymorphisms and haplotypes of microsatellite locus in exon 5 of the MICA gene and intron 1 of the MICB gene and human leukocyte antigen-B (HLA-B) gene based on 106 samples of the Guangzhou Han population through means of polymerase chain reaction and the fluorescent technique (6-FAM). The corresponding haplotype frequencies, linkage disequilibrium values and relative linkage disequilibrium values were estimated based on population data. The results show that the genotype distributions of MICA and MICB microsatellite and HLA-B satisfy the Hardy-Weinberg equilibrium. In total, five alleles of MICA microsatellite locus and 14 alleles of MICB microsatellite locus were observed. MICA A5 was the most common allele (0.2877), whereas A4 was the least common (0.1321). MICB CA14 was the most common allele (0.3255), and CA19 and CA28 were the two least common (0.0047). CA27 was not observed at all. Five kinds of MICA-MICB haplotypes, 18 kinds of MICA-HLA-B haplotypes and 12 kinds of MICB-HLA-B haplotypes occurred at frequencies of more than 1%. The common haplotypes of MICA-MICB, MICA-HLA-B and MICB-HLA-B were A5-CA14, A5.1-CA18, A4-CA26, A9-CA15, A5-B*15(62), A5.1-B*1301/1302, A4-B*1301/1302, A6-B*51, A6-B*4403, A9-B*3802, CA14-B*4601, CA18-B*1301/1302 and CA26-B*1301/1302, and these haplotypes showed strong linkage disequilibrium. The polymorphisms and haplotype distributions of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population have their own distinct genetic characteristics. The microsatellite locus of exon 5 of the MICA gene and intron 1 of the MICB gene could therefore be used as genetic markers in the studies of anthropology, gene linkage analysis in genetic diseases, individual identification and paternity testing in forensic medicine.     

广州大学城广州管圆线虫疫源地调查

目的捕捉广州大学城褐云玛瑙螺(Achatina fulica)检查广州管圆线虫(Angiostrongylus cantonensis)第Ⅲ期幼虫的感染情况。方法采集大学城10所高校生活区和教学区褐云玛瑙螺,人工消化酶消化分离第Ⅲ期幼虫,计算感染率和感染度并与广州其他地区进行比较。结果除广东外语外贸大学、华南理工大学2个校园内未捕捉到褐云玛瑙螺外,其他8所高校均发现有褐云玛瑙螺;广州大学城广州管圆线虫总体感染率为11.8%(76/642),平均感染度为872条/螺,阳性螺中最高15725条,最低17条;中山大学校园内感染率和感染度比其他校园高,分别为22.0%(56/255),1007条/螺。结论广州大学城广州管圆线虫感染率低于广州其他地区。     

广州北郊南昆山自然保护区卫氏并殖吸虫超高度疫源地首报

目的 调查广州北郊南昆山自然保护区并殖吸虫流行分布状况. 方法 采集调查点山溪中螺蛳2012只,溪蟹63只,收集疫源地野山猫粪便3份,2只人工感染家猫粪便2份.检查并殖吸虫尾蚴、囊蚴和虫卵.解剖人工感染虫卵阳性猫,查找并殖吸虫成虫. 结果 螺蛳体并殖吸虫尾蚴感染率为0.15‰(3/2000).螺种为放逸短沟蜷.蟹体卫氏并殖吸虫囊蚴感染率为100%(59/59).感染度:2～516个囊蚴/只蟹,2～10个囊蚴/克蟹.蟹种为平和华溪蟹.2份野山猫粪便检出并殖吸虫卵,感染率为66.66%(2/3).解削两只人工感染阳性猫检获卫氏并殖吸虫成虫11条. 结论 首次发现广州北郊南昆山自然保护区存在严重卫氏并殖吸虫流行,为超高度疫源地(I级).鉴于卫氏并殖吸虫是我国主要致病并殖吸虫,该疫源地属国家级自然保护区,也是4A旅游区及著名的避暑胜地,游人如误饮用生山泉水,具有感染卫氏并殖吸虫的潜在危害,必须引起高度重视.