The parabiliary venous system

Summary The parabiliary venous system originates from the pancreatico-duodenal and pyloro-duodenal veins, runs along the common bile-duct and the hepatic artery, and divides in the liver hilum into a venous network within the hilar plate. Embryologically, this system, apparently independent of the portal vein, develops together with the bile-ducts and the hepatic artery: these three structures are within the substance of the vasculo-biliary sheaths, and the whole complex invades the liver well after the distribution of the portal vein has been established. It should be pointed out that segments I and IV also appear rather late. Seventy-four specemins with injection of the system have been studied. The hilar plexus sends branches to the veins of the segments adjacent to the hilum. Some vessels directly supply the inferior surface of the quadrate lobe or the caudate lobe, or the left lobe. In 46.50% of specemins, part of the cystic veins are anastomosed with the Parabiliary system.

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Le système veineux parabiliaire

Résumé Le système veineux parabiliaire prend origine dans les veines pancréatico-duodénales et pyloro-duodénales, monte le long de la voie biliaire et l'artère hépatique, et se termine dans le hile dans un lascis veineux situé dans la plaque hilaire. Embryologiquement il semble étranger à la formation de la veine porte, se constitue en même temps que les canaux biliaires et les artères intra-hépatiques: ces trois éléments sont situés dans la texture même des enveloppes vasculo-biliaires, et le tout envahit le foie bien après la pénétration de la veine porte. L'étude porte sur 74 foies dans lesquels le système s'est trouvé injecté. Le plexus hilaire envoie des collatérales qui se jettent dans les veines des segments adjacents au hile. Mais certaines branches irriguent directement la face inférieure du lobe carré, ou le lobe gauche. Dans 46,50% des cas, une partie des veines cystiques se jettent dans ce système.

     

术苓健脾胶囊对TNBS诱导的大鼠实验性结肠炎的作用及机制

探讨术苓健脾胶囊（术苓）对2,4,6-三硝基苯磺酸（TNBS）诱导的大鼠实验性结肠炎的作用及其机制。采用2.5%TNBS灌肠制备大鼠实验性结肠炎模型。将大鼠随机分为正常组、模型组、肠炎宁（180 mg/kg）组以及术苓低剂量（40 mg/kg）、高剂量（120 mg/kg）组。造模后药物治疗7 d后处死大鼠。其间每日记录大鼠体重,观察大鼠疾病活动状态。实验结束后,取结肠组织进行HE病理学分析、检测结肠组织中髓过氧化物酶（MPO）酶活、诱导型一氧化氮合酶（iNOS）、炎性细胞因子（IL-6、IL-1β、IFN-γ、IL-10）及紧密连接蛋白（occludin、ZO-1）的表达水平,并检测血清中炎性细胞因子（IL-6、IL-1β）的含量。结果表明,与模型组相比,术苓给药显著缓解了TNBS造模引起的体重下降、疾病活动指数（DAI）升高,缓解了结肠组织的缩短、水肿以及病理学损伤,减少了炎性细胞浸润、隐窝的破坏与杯状细胞的丢失,降低了结肠组织MPO酶活性、iNOS与炎性细胞因子的水平,增加了结肠紧密连接蛋白的表达,同时降低了血清中的炎性因子的含量。结果表明,术苓通过降低炎性因子水平,增加肠道紧密...     

双诺希胶囊对实验性高脂血症的影响

目的　验证双诺希胶囊 ( SHNX)对高脂血症大鼠血脂的影响 .方法　用高脂饲料喂饲大鼠建立高脂血症模型 ;随机分为 6组 ,即正常对照组、高脂模型组、SHNX大剂量组( SHNXH1.2 0 0 g· kg- 1 )、SHNX中剂量组 ( SHNXM0 .60 0 g· kg- 1 )、SHNX小剂量组 ( SHNXL 0 .3 0 0 g· kg- 1 )和安妥明组 ( Clofibrate) ,连续喂饲并灌胃给药 3 0 d后 ,观察 SHNX对高脂血症大鼠血脂含量的影响 .结果　 SHNX能明显降低血清总胆固醇 ( TC)、三酰甘油 ( TG)含量 ,亦能明显提高血清高密度脂蛋白亚组分 胆固醇 ( HDL2 - C)及高密度脂蛋白胆固醇 ( HDL - C)的含量 .结论　 SHNX对血脂紊乱大鼠有明显的治疗效果 .     

溶栓通脉胶囊纤溶活性和毒性的实验研究

目的:探讨溶栓通脉胶囊的纤溶性和毒性。方法:应用纤维蛋白平板法和纤维蛋白加热平板法对溶栓通脉胶囊的纤溶活性进行实验性研究;同时进行急性毒性试验。结果与结论:溶栓通脉胶囊具有很强的纤溶性且安全、无毒副作用。     

克肝胶囊治疗慢性乙型肝炎的临床研究

目的：观察克肝胶囊治疗慢性乙型肝炎的临床疗效。方法：用克肝胶囊治疗６０例慢性乙型肝炎患并与干抗素组（６０例）进行对照。结果：中药克肝胶囊能明显改善临床症状,总有效率（９３．３３％）,明显优于干扰素组（Ｐ＜０．０１）。与治疗前比较,能显降低ＡＬＴ、ＡＳＴ、γ－ＧＴ（Ｐ＜０．０１）,显升高ＡＬＢ、Ａ／Ｇ（Ｐ＜０．０５）,与干扰素组比无显性（Ｐ＞０．０５）。结论：克肝胶囊能明显改善慢性乙型肝炎的     

通脉络胶囊抗心肌缺血和耐常压缺氧作用的研究

目的：研究通脉络胶囊对实验动物的抗心肌缺血和耐常压缺氧作用,为临床用药提供依据。方法：给兔耳静脉注射脑垂体后叶素,造成急性心肌缺血状态,以心电图ＳＴ段及Ｔ波产生的变化为指标,来研究通脉络胶囊对抗垂体后叶素引起的兔心肌缺血作用;将小鼠放在密闭的容器中造成缺氧环境,以小鼠在常压缺氧条件下呼吸停止的时间为指标,来研究小鼠的耐常压缺氧作用。各实验均设四组动物：通脉络胶囊高、低剂量组、复方丹参片组、水对照组。结果：通脉络胶囊高剂量组与对照组比较有极显著性差异（Ｐ＜０．０１）;低剂量组有显著性差异（Ｐ＜０．０５）。与复方丹参片组比较,抗心肌缺血作用无显著性差异（Ｐ＞０．０５）;耐常压缺氧作用的高剂量组有极显著性差异（Ｐ＜０．０１）。结论：通脉络胶囊有显著的抗心肌缺血作用和耐常压缺氧作用,它的疗效与剂量有依赖关系;抗心肌缺血作用与复方丹参片近似,耐常压缺氧作用远较复方丹参片强。     

Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model

Objective: To study the effect of Xiongshao capsule (XSC) on vascular remodeling in porcine coronary balloon injury model.Methods: Coronary artery restenosis model was established by oversized balloon injury at mid-region of the left anterior descending coronary artery. They were divided into 5 groups, untreated or treated with probucol, Xueguantong, low and high dose of XSC respectively, and compared. The effect of XSC on late lumen loss resulted from vascular remodeling was evaluated by quantitative histological method with combining histopathological analysis and coronary angiographie examination.Results: The (59 ± 20)% of late lumen loss was caused by vascular remodeling and (41 ± 20)% caused by intimai hyperplasia. Compared with the control group, all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 ), both low and high dose of XSC could significantly reduce the late lumen loss caused by remodeling (P<0.05 and P<0.01 respectively).Conclusion: Vascular remodeling plays an important role in late lumen stenosis formation in coronary artery after balloon injury. XSC could significantly inhibit the pathological vascular remodeling, and thus reduce the late lumen loss and prevent the restenosis of the injured coronary artery. Part of a National Ninth-Five Planning Project (No. 96-9060601)     

平消胶囊配合化学药物治疗晚期肺腺癌的临床观察

本文应用平消胶囊配合化学药物治疗52例晚期肺腺癌。全组CR2例,PR25例,总有效率为51.9%,且73.0%的患者症状改善,75.0%的患者功能状态得到改善,1年生存率为36.5%。结果表明平消胶囊与化学药物并用可以提高晚期肺腺癌的治疗效果,改善患者的生存质量。平消胶囊是治疗晚期肺腺癌的有效中成药之一。