C2R模型与C2GS2模型在胸外科监护室护理人力资源效率评价中的应用研究

目的 研究某市胸外科监护室护理单元相对效率,为管理者合理配置护理人力资源提供建议.方法 应用C2R模型和C2GS2模型对某市12个胸外科监护室护理单元的相对效率进行评价.结果 从纯粹的投入产出技术层面评估,参评的护理单元中,相对有效的决策单元占75%;相对无效的决策单元通过各指标的理想值可达到相对有效.结论 胸外科监护室护理人力资源存在不足与低效并存的现象;应用DEA模型对护理效率进行评估可以为人力资源配置提供科学依据.     

褐藻多糖GS201对脑神经细胞生存的影响

采用体外神经细胞培养的方法 ,检测 GS2 0 1对神经细胞的营养作用。结果表明 ,GS2 0 10 .0 1、0 .1、1、10 mg· L-1能显著提高神经细胞的存活率 ,其中 10 mg· L-1效果最好 ,并呈一定的量效关系     

两种干预方法缓解早产儿眼底筛查所致疼痛的效果研究

目的探讨两种干预方法缓解早产儿眼底筛查所致疼痛的效果。方法纳入2017年7月～2019年6月某三级甲等专科医院早产儿病房进行眼底筛查的168例早产儿进行研究,依据随机对照原则分为三组,各56例,对照组早产儿采取常规眼底筛查,非营养性吸吮(NNS)组早产儿接受NNS护理,25%葡萄糖(GS)+NNS组早产儿接受25%GS安慰奶嘴护理。比较三组早产儿不同时间点疼痛、心率(HR)、血氧饱和度(SpO_2)变化情况。结果 NNS组与25%GS+NNS组早产儿筛查过程中、筛查后1 min PIPP评分、HR均低于对照组,SpO_2均高于对照组,差异显著(P0.05);GS+NNS组早产儿筛查过程中、筛查后1 min PIPP评分、HR均低于NNS组,SpO_2高于NNS组,差异显著(P0.05)。结论采取25%GS+NNS的干预方式能够有效减轻早产儿眼底筛查所致疼痛,值得临床推荐。     

The added value of systematic biopsy in men with suspicion of prostate cancer undergoing multiparametric MRI-targeted biopsy

Purpose

Incorporation of multiparametric magnetic resonance imaging (mpMRI) and targeted biopsy (TBx) in the diagnostic pathway for prostate cancer (CaP) is rapidly becoming common practice. In men with a prebiopsy positive mpMRI a TBx only approach, thereby omitting transrectal ultrasound-guided systematic biopsy (SBx), has been postulated. In this study we evaluated the additional clinical relevance of SBx in men with a positive prebiopsy mpMRI (Prostate Imaging Reporting and Data System [PI-RADS] ≥ 3) undergoing TBx for CaP detection, Gleason grading and CaP localization.

Construct validity of the Maslach Burnout Inventory‐General Survey

The construct validity of the Maslach Burnout Inventory (MBI) has been a major point of focus for many studies. The validity of the MBI‐General Survey (MBI‐GS), a newly developed instrument intended for use outside the human services has not been sufficiently investigated. The aim of this present study is to investigate the validity of the MBI‐GS. The Japanese language version of the MBI‐GS was prepared for this research and it was administered to a sample of intermediate managers (n = 696) working for a manufacturing company in Japan. The total of 691 effective data were obtained. The exploratory factor analysis replicated the same three‐factor structure (Exhaustion, Cynicism, and Professional Efficacy) as the original whereas inter‐factor correlation between Exhaustion and Cynicism was moderate. Cronbach's alpha coefficients for all three subscales were above 0.80. The confirmatory factor analysis supported a three‐factor model whereas Exhaustion and Cynicism were moderately related. To investigate the construct validity, three subscales of the MBI‐GS were then related to selected work characteristics. Based on conservation of resources theory, differential patterns of effects were predicted among the correlates and the burnout subscales. A path analysis revealed that the expectations were largely supported, suggesting that the meaning of the three subscales is quite different with a path from Exhaustion to Cynicism. The study found support for the construct validity of the MBI‐GS. Copyright © 2004 John Wiley & Sons, Ltd.     

人参皂甙对大鼠离体主动脉活动的影响

在一定GS浓度下对大鼠离体主动脉存在双向性作用。正常状态下使其收缩,而在NA收缩的基础上则引起其舒张。 GS对大鼠离体主动脉活动影响的作用途径及其机制目前尚不清楚,其收缩和舒张均与胰岛素的效应相似,由此提示可能是类胰岛素样的作用。GS的舒张效应可能不需动脉壁内膜参与,而GS收缩效应可被阿托品所阻断,可能与平滑肌上胆碱能M受体激活有关。     

Advanced precancerous lesions in the liver

We will focus on precursors of the most common liver cancer, i.e. hepatocellular carcinoma (HCC), which takes place in 90% of cases in a hepatitis/cirrhotic setting. High grade dysplastic nodules (HG-DN) are small sizable nodules and the most advanced precancerous lesions of the liver, with a risk of malignant transformation of about 30–40% at 24 months. We will survey the diagnostic distinction between them and early HCC from a clinical, radiological and pathological point of view. The use of a diagnostic algorithm supported by international guidelines is the best practice to manage HG-DN and early HCC. There is no typical imaging for HG-DN, needing all of them to be biopsied for characterization. The natural history of HG-DN is not predictable in individual cases and additional markers should be validated to increase the diagnostic accuracy and predict the behaviour. The treatment of HG-DN is under investigation.