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961.
962.
This pilot study examined whether a combined aerobic resistance exercise program reduced fatigue and the potential inflammatory and epigenetic mechanisms in patients with head and neck cancer (HNC) receiving intensity-modulated radiotherapy. The exercise group (N = 12) received a 3-month supervised aerobic resistance exercise intervention that was initiated before a 6-week radiotherapy regimen; the control group (N = 14) received standard care. Fatigue was measured using Multidimensional Fatigue Inventory-20; physical function measures included a 6-minute walk distance (6MWD), chair stands, bicep curls, and hand grip strength. Inflammatory markers and DNA methylation data were acquired using standardized protocol. Patients were mostly white (93%) and male (81%) with a mean age of 57 years. At the end of the intervention, the exercise group had a marginal decrease in fatigue compared with the control (−5.0 vs. 4.9; P = 0.10). The exercise group had a significantly greater improvement in 6MWD (29.8 vs. −55.5 m; P = 0.04), and a marginally smaller decline in hand grip (−0.3 vs. −5.8 lbs; P = 0.05) at the end of the intervention than the control. No significant difference in inflammatory markers was observed between groups. Lower plasma interleukin (IL) 6, IL1 receptor antagonist, tumor necrosis factor α (TNFα), soluble TNF receptor II and C-reactive protein were significantly associated with increased 6MWD, chair stand, and bicep curl at the end of the intervention (p < 0.05). Among the 1152 differentially methylated sites (DMS) after intervention (p < 0.001), 163 DMS were located in gene promoter regions. Enrichment analysis suggested that the top 10 upstream regulators were associated with tumor (HNF4A, RPP38, HOXA9, SAHM1, CDK7, NDN, RPS15) and inflammation (IRF7, CRKL, ONECUT1). The top 5 diseases or functions annotations of the 62 hypermethylated DMS indicated anti-tumor and anti-inflammatory effects that might be linked to exercise. These findings suggest that exercise may improve physical performance and reduce fatigue, which could be further linked to decreased inflammation, during active radiotherapy for HNC patients. Larger studies are warranted. 相似文献
963.
PurposeFatigue has been recognized as a common non-motor problem in patients with Parkinson’s disease (PD). The determination of the clinical correlates of fatigue in PD patients is necessary. The purpose of this study was to explore the risk factors related to the severity of fatigue in PD.Patients and methodsIn this study, 141 patients with PD were recruited. All patients were evaluated comprehensively, including motor function, fatigue severity scale (FSS), cognition and psychiatric status. Brain magnetic resonance imaging (MRI) examinations were performed to assess the severity of white matter hyperintensities, and the presence of silent lacunes, medial temporal lobe atrophy (MTLA), and global cortical atrophy (GCA). The crude associations of variables with FSS were examined using Pearson (nor-mally distributed) or Spearman correlation (categorical or non-normal distributed) analyses. Multiple linear regression analysis was performed to find the correlates of fatigue severity in PD patients.ResultsIn the whole sample, with FSS as the dependent variable in a linear regression model, Hamilton Depression Rating Scale (HAM-D), GCA, female sex were significant correlates of FSS, accounting for 24% of the variance of it. When subjects with depression (HAM-D ≥ 35) were excluded, HAM-D, GCA, female sex remained significant correlates of FSS, accounting for 22% of the variance of FSS. There is no correlation between white matter hyperintensities and FSS.ConclusionGCA may be an important correlate of the fatigue severity commonly observed in PD patients. 相似文献
964.
《Gait & posture》2020
BackgroundDescribing the response of spatiotemporal gait characteristics, and related variables such as variability and stiffness, to different stressors is important to better understand spring-mass model.Research questionThis study aimed to examine the effect of fatigue induced by a running protocol on spatiotemporal gait parameters, step variability and vertical (Kvert) and leg stiffness (Kleg) during running on a treadmill.MethodsTwenty-two trained male endurance runners performed a 60-min time trial run. An analysis of spatiotemporal parameters (contact time [CT], flight time [FT], step frequency [SF] and step length [SL]), step variability (in terms of coefficient of variation [CV]) and stiffness was conducted in two different conditions: non-fatigued (before the protocol) and fatigued (after the protocol).ResultsThe pairwise comparisons (i.e., non-fatigued vs. fatigued condition) indicated that temporal parameters (i.e., CT and FT) experienced significant changes (p = 0.001 and <0.001, respectively). Step variability increased in presence of fatigue, with higher CV in CT (p = 0.039), FT (p = 0.005), SF (p = 0.046) and SL (p = 0.027) after the running protocol. The Kleg experienced a reduction in the fatigued condition (p < 0.001) whereas the Kvert remained unchanged (p = 0.602).SignificanceThe results indicate that fatigue induced by a 60-min time trial run causes some adaptations in spatiotemporal gait characteristics and stiffness in trained endurance runners. Specifically, in the presence of fatigue, the athletes showed greater CT and shorter FT, higher step variability and lower leg stiffness. 相似文献
965.
Spinocerebellar ataxia type 10 (SCA10) is a rare dominantly inherited neurodegenerative disorder characterized by cerebellar ataxia, dysarthria, ocular dysmetria, and seizures in some populations. Fatigue has been described in SCA1, SCA3, but has not been objectively investigated in SCA10. Our aim is to investigate the presence and related causal factors of fatigue among SCA10 patients. Twenty-eight patients with SCA10 and matched healthy controls were included and assessed using the Scale for the Assessment and Rating of Ataxia (SARA), Modified Fatigue Impact Scale (MFIS), Beck Inventory Depression (BDI) and Epworth Sleepiness Scale (ESS). Fatigue was evidenced in 32% of SCA10 versus 3.6% for the control group (p = 0.005). The following independent variables were not significant predictors for MFIS-BR: duration of disease, SARA and BSS. Age at onset of disease (r = −0.307, p = 0.021) and EDS (r = −0.347, p = 0.014) were mild to moderate predictors of fatigue. Similar to other SCAs, fatigue is common in SCA10 patients, suggesting a possible role of a common topographic degenerative pattern in its pathophysiology. 相似文献
966.
IntroductionFatigue is one of the most common disabling symptoms in patients with multiple sclerosis (MS) which is present in 75% of these patients and is usually associated with functional disabilities. According to the literature, there is no general agreement on the effectiveness of the existing treatments for fatigue in patients with MS. As transcranial direct current stimulation (tDCS) is a relatively new method in the treatment of fatigue symptoms in patients with MS, the purpose of this study was to systematically review published evidence conducted to assess the effects of tDCS on fatigue in patients with MS.Material & methodsA thorough literature search of published articles was conducted from 1996 to 2019 in different databases including PubMed, Science Direct, OVID, Google Scholar, Cochrane Library, Scopus, Embase, ProQuest and web of science with keywords of “tDCS”, “multiple Sclerosis” and “Fatigue”. Results yielded 1017 studies, which after excluding articles based on duplication and title and abstract, 8 of them were selected for review in this study.ResultsThe results from the literature revealed that six studies indicated positive effects of tDCS stimulation on fatigue reduction. In four studies stimulation was over the right dorsolateral prefrontal cortex (DLPFC); in three studies stimulation placed over the whole body’s primary somatosensory cortex (S1); and in one study stimulation applied over the posterior parietal cortex. In most studies, no serious side effects were reported.ConclusionMost studies revealed that tDCS can reduce the adverse effects of MS-related fatigue in particular cognitive type. As follow-ups were either absent or short period, as well as the application of treatment protocols and measurement instruments were different, it was very difficult to draw strong conclusion on the effects of tDCS in patients with MS. However, further large scale studies with long term follow-up are still recommended. 相似文献
967.
Patients with depressive disorders show a wide range of clinical manifestations including cognitive and neurovegetative symptoms. Importantly, these symptoms can differ in terms of biological etiology, and deconstructing depression into specific symptoms may provide valuable insight into the underlying neurobiology. Little research has examined inflammation in the context of depressive dimensions. Here we conduct a narrative review of the existing literature (21 studies) to elucidate whether the depression-inflammation link is symptom specific. Overall, there is evidence that an association exists between neurovegetative symptoms of depression and inflammation, independent of cognitive symptoms. The same cannot be said of cognitive symptoms and inflammation. There is also some evidence of gender differences in the directionality of the relationship between depression and inflammation. Potential explanations for these findings, limitations of the existing literature and recommendations for future research design are discussed. 相似文献
968.
969.
970.
目的探讨疲劳与倦怠的关系,及满意度在二者关系中的调节作用,为基层医务人员倦怠的干预提供一定理论依据和指导。方法采用多阶段分层抽样方法,对广州、江门、惠州、潮州4个样本市的622名基层医务人员进行调查,调查内容包括调查对象的基本情况,采用疲劳量表、满意度量表、工作倦怠量表进行调查。最终回收有效问卷533份。将调查数据运用SPSS 22.0和AMOS22.0进行整理与分析。结果医务人员的疲劳对情绪衰竭(23.1%)和人格解体(7.3%)具有正向预测作用,而满意度对疲劳与倦怠间的关系有负向调节作用(β=-0.096;β=-0.130, P <0.01)。结论我国基层医务人员的职业倦怠较为普遍,基层医疗机构的管理者应从减少医务人员疲劳和提高满意度两方面入手对医务人员的职业倦怠进行干预。通过增加工作资源,提供组织支持,来提高医务人员的满意度,调节疲劳对倦怠的正向预测作用,达到减少疲劳,控制倦怠的目的。 相似文献