全文获取类型
收费全文 | 2915篇 |
免费 | 216篇 |
国内免费 | 104篇 |
专业分类
耳鼻咽喉 | 80篇 |
儿科学 | 151篇 |
妇产科学 | 43篇 |
基础医学 | 103篇 |
口腔科学 | 50篇 |
临床医学 | 233篇 |
内科学 | 350篇 |
皮肤病学 | 35篇 |
神经病学 | 232篇 |
特种医学 | 42篇 |
外科学 | 252篇 |
综合类 | 658篇 |
预防医学 | 410篇 |
眼科学 | 46篇 |
药学 | 180篇 |
1篇 | |
中国医学 | 310篇 |
肿瘤学 | 59篇 |
出版年
2024年 | 12篇 |
2023年 | 40篇 |
2022年 | 69篇 |
2021年 | 131篇 |
2020年 | 108篇 |
2019年 | 72篇 |
2018年 | 74篇 |
2017年 | 85篇 |
2016年 | 113篇 |
2015年 | 104篇 |
2014年 | 207篇 |
2013年 | 246篇 |
2012年 | 251篇 |
2011年 | 251篇 |
2010年 | 188篇 |
2009年 | 175篇 |
2008年 | 169篇 |
2007年 | 151篇 |
2006年 | 107篇 |
2005年 | 90篇 |
2004年 | 84篇 |
2003年 | 82篇 |
2002年 | 59篇 |
2001年 | 56篇 |
2000年 | 50篇 |
1999年 | 40篇 |
1998年 | 29篇 |
1997年 | 34篇 |
1996年 | 21篇 |
1995年 | 14篇 |
1994年 | 19篇 |
1993年 | 13篇 |
1992年 | 8篇 |
1991年 | 12篇 |
1990年 | 8篇 |
1989年 | 6篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 9篇 |
1985年 | 11篇 |
1984年 | 9篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有3235条查询结果,搜索用时 78 毫秒
41.
卵巢过度刺激综合征是辅助生殖技术常见的并发症,通常在排卵后2周或2周以上发生。然而自发性卵巢过度刺激综合征极其罕见,一些病例报道表明,自发性卵巢过度刺激综合征的发生与卵泡刺激素受体突变、高人绒毛膜促性腺激素水平、高促甲状腺激素水平、促性腺激素垂体腺瘤等有关。现报告1例双胎妊娠合并自发性卵巢过度刺激综合征的病例,并进一步探讨自发性卵巢过度刺激综合征的可能病因、诊断和治疗原则。 相似文献
42.
《Archivos de bronconeumologia》2020,56(11):725-741
Community-acquired pneumonia (CAP) is a prevalent disease among children and is frequently associated with both diagnostic and therapeutic uncertainties. Consensus has been reached between SEPAR, SENP and SEIP, and their conclusions are as follows:Etiology depends mainly on age and other factors and no single analytical marker offers absolute diagnostic reliability.In the event of clinical suspicion of pneumonia in a healthy child, chest X-ray is not necessary. Chest ultrasound is increasingly implemented as a follow-up method, and even as a diagnostic method.The empirical antibiotic treatment of choice In typical forms of the disease is oral amoxicillin at a dose of 80 mg/kg/day for 7 days, while in atypical presentations in children older than 5 years, macrolides should be selected. In severe typical forms, the combination of 3rd generation cephalosporins and cloxacillin (or clindamycin or vancomycin) administered intravenously is recommended.If pleural drainage is required, ultrasound-guided insertion of a small catheter is recommended. Intrapleural administration of fibrinolytics (urokinase) reduces hospital stay compared to simple pleural drainage.In parapneumonic pleural effusion (PPE), antibiotic treatment combined with pleural drainage and fibrinolytics is associated with a similar hospital stay and complication rate as antibiotic treatment plus video-assisted thoracoscopy (VATS).Systematic pneumococcal conjugate vaccination is recommended in children under 5 years of age, as it reduces the incidence of CAP and hospitalization for this disease. 相似文献
43.
《介入医学杂志(英文)》2020,3(2):65-76
This study aims to report the Budd-Chiari syndrome clinical research status and progress that has occurred in over nearly 30 years in China, and emphasize the value of imaging in facilitating the diagnosis of Budd-Chiari syndrome based on more than 2500 cases. Findings on ultrasonography, computed tomography, magnetic resonance imaging, and digital subtraction angiography images are used to propose new Budd-Chiari syndrome types and subtypes. The new subtype classification presented here has important value for guiding interventional treatment. This study also proposes a new concept of anatomical and functional obstruction of hepatic vein that stresses the compensatory value of accessory hepatic vein and azygos vein and describes the risk of manipulation of the communication branch of inferior vena cava obstruction in interventional therapy. 相似文献
44.
45.
杨洋 《国际输血及血液学杂志》2014,37(5):479-483
先天性红细胞生成异常性贫血(CDA)是一组以骨髓红系无效造血、有独特的光学显微镜及电镜形态学改变为特征的先天性贫血性疾病.其临床表现主要为自出生或婴幼儿时期,即开始出现不同程度的贫血、黄疸及肝、脾大,并常继发胆石症和铁过载.近年,多数文献研究已对单一类型CDA或CDA Ⅰ、Ⅱ、Ⅲ型及变异型的临床特征,分子机制和诊断方法等进行概述.笔者主要从各型CDA发病机制中的相关致病基因、异常信号传导、细胞周期紊乱与膜的糖基化异常及基因型与表现型的关系等进行更深入的综述研究,旨在整体了解和掌握各型CDA,及探索各型CDA之间可能存在的联系. 相似文献
46.
47.
目的 分析急性心肌梗死患者并发肺炎的病因及预后.方法 选取2011年1月~2013年10月本院102例急性心肌梗死患者,其中合并肺炎53例,以无肺炎的49例为对照组,对多种因素进行回顾性分析.结果 急性心肌梗死并发肺炎与年龄、绝对卧床≥7d、应用镇静剂≥5d、心功能异常等多种因素有关;好转率明显低于对照组.结论 急性心肌梗死并发肺炎诱因较多,积极预防、控制肺炎对治疗具有重要作用. 相似文献
48.
《Pancreatology》2016,16(4):469-476
ObjectiveWe sought to define the severity and natural history of hypertriglyceridemia induced acute pancreatitis (HTG-AP), specifically whether HTG-AP causes more severe AP than that caused by other etiologies.MethodsSystematic review of the English literature.ResultsThirty-four studies (15 countries; 1972–2015) included 1340 HTG-AP patients (weighted mean prevalence of 9%). The median admission triglyceride concentration was 2622 mg/dl (range 1160–9769). Patients with HTG have a 14% weighted mean prevalence of AP. Plasmapheresis decreased circulating triglycerides, but did not conclusively affect AP mortality. Only 7 reports (n = 392 patients) compared severity of HTG-AP to that of AP from other etiologies. Of these, 2 studies found no difference in severity, while 5 suggested that HTG-AP patients may have increased severity compared to AP of other etiology.Conclusions1) hypertriglyceridemia is a relatively uncommon (9%) cause of acute pancreatitis; however, patients with hypertriglyceridemia have a high (14%) incidence of acute pancreatitis; 2) plasmapheresis may offer specific therapy unique to this patient population; and 3) data specifically comparing the severity of HTG-AP with AP caused by other etiologies are heterogeneous and scarce. 相似文献
49.
《Immunobiology》2017,222(2):228-240
While a number of endogenous risk factors including age and genetics are established for Alzheimer’s disease (AD), identification of acquired, potentially preventable or treatable causes, remains limited. In this paper, we review three epidemiologic case studies and present extensive biologic, immunologic and anatomic evidence to support a novel hypothesis that Bordetella pertussis (BP), the bacterium better known to cause whooping cough, is an important potential cause of AD. Cross-cultural documentation of nasopharyngeal subclinical BP colonization reflecting BP-specific mucosal immunodeficiency, proximate anatomy of intranasal mucosal surfaces to central nervous system (CNS) olfactory pathways, and mechanisms by which BP and BP toxin account for all hallmark pathology of AD are reviewed, substantiating biologic plausibility. Notably, respiratory BP infection and BP toxin secreted from subclinical BP colonization can account for the initiation and accumulation of amyloid β plaques and tau tangles. Additional mechanisms consistent with the immunobiologic effects of subclinical BP colonization include microglial activation and inflammation, atrophy and neurodegeneration, excitotoxicity, distinctive anatomic distribution and sequential spread of disease, impaired glucose utilization, and other characteristic CNS pathology of AD. We conclude by assessing the evidence for causation against the Bradford Hill criteria, and advocate for further investigation into the potential role of BP in the etiology of AD. 相似文献
50.
克山病的病因与流行机制 总被引:2,自引:3,他引:2
杨建伯 《中国地方病学杂志》2004,23(4):293-296
目的报告关于克山病病因的研究结果。方法病因流行病学方法;病理学和实验病理方法;文献学方法。结果克山病病因流行病学研究所见:克山病的病因是特定自然、社会、生活条件下形成的黄绿青霉毒素(citreoviridin,CIT)中毒;传播途径是病区产的粮食与饮水无关;玉米、小米等粮食传病,小麦不传或少传;粮食在湿冷环境中被青霉菌污染并产生CIT毒素。克山病的病理、病理化学、实验病理研究所见:从亚急型克山病以及解剖可见,心肌的早期病理改变是线粒体功能与结构的破坏。ATPases同琥珀酸脱氢酶等系列心肌酶的活性被明显抑制、改变、比例失衡,同时线粒体的结构也出现了相应的改变。心肌线粒体肿胀,嵴膜破坏,线粒体膜融合、消失。CIT毒素对心肌线粒体的作用机制:CIT是ArrP的类似物,可与AIPases相作用而降低其活性。由此开始,逐步发展、变化,最终导致克山病特异的心肌坏死。结论上述的3个方面基本是相互独立的各自发现,但可紧密的相互认证,相互支持,支持克山病的致病因子可能是青霉菌污染粮食产生的黄绿青霉毒素。 相似文献