输精管绝育术后结节的病理研究

本研究通过对输精管绝育术后局部有疼痛症状结节35例与无症状结节25例的光镜、电镜、组化、免疫组化等比较研究,提出结节产生的主要病理基础是精子外漏至周围间质所引起的无菌性炎症的一系列反应。预防的关键是减少精子漏出。     

中药“425”对血吸虫卵肉芽肿病变免疫调节作用的机理研究

本文试验结果发现，应用“４２５”制剂可明显增强宿主脾细胞在体外自发性的及在ＬＰＳ刺激下的增生反应，明显抑制其在ＰＨＡ刺激下的增生反应，而用药后宿主脾细胞在特异性抗原刺激下的增生反应未见明显改变；虽然用药组感染鼠的脾脏明显小于对照组，但血清及虫卵肉芽肿培养上清中特异性抗体ＩｇＧ水平未见明显改变。研究结果表明，“４２５”制剂具有双重非特异性免疫调节作用。该制剂抑制宿主肝组织内虫卵肉芽肿病变的机理除了在于其能非特异地增强宿主Ｂ细胞介导的体液免疫应答外，该制剂对宿主体内Ｔ细胞介导的细胞免疫应答的非特异性抑制作用可能起了更重要的作用。     

胸骨浆细胞肉芽肿1例报告

浆细胞肉芽肿临床较少见,常发生于肺、眼眶及消化道等部位,发生于骨则罕见。大部分骨的浆细胞肉芽肿发生于颞骨,发生于胸骨者尚少见报道。现将我院胸骨浆细胞肉芽肿1例报告如下。     

Review of long-term adverse effects associated with the use of chemically-modified animal and nonanimal source hyaluronic acid dermal fillers

Although only recently introduced, chemically-modified hyaluronic acid dermal fillers have gained widespread acceptance as “redefining” dermal fillers in the fields of dermatology and cosmetic facial surgery. Although hyaluronic acid-based dermal fillers have a low overall incidence of long term side effects, occasional adverse outcomes, ranging from chronic lymphoplasmacytic inflammatory reactions to classic foreign body-type granulomatous reactions have been documented. These long-term adverse events are reviewed.     

Lethal midline granuloma: impact of imaging studies on the investigation and management of destructive mid facial disease in 13 patients

Summary In 13 patients presenting as lethal midline granuloma (LMG), computed tomography proved essential for determining the extent of the disease, guiding biopsy and planning radiotherapy. Magnetic resonance imaging (MRI) was also helpful for the latter, because it could distinguish fluid retained within the paranasal sinuses from solid masses and tumour from granulation tissue; it was of little value for detecting bone lysis. Eight of the 13 patients proved to have T-cell lymphoma, two had Crohn's disease, in one the lesion was factitious and two had granulomas without diagnostic histological features.     

The effect of the neurokinin antagonist FK-224 on the cough response to inhaled capsaicin in a new model of guinea-pig eosinophilic bronchitis induced by intranasal polymyxin B

Eosinophilic bronchitis without asthma can cause a persistent non-productive cough which is resistant to bronchodilator therapy. To understand the mechanism of the cough in this disorder, an animal model of eosinophilic bronchitis was developed. Guinea-pigs were treated with transnasal administration of polymyxin B or saline twice a week for 3 weeks. The number of eosinophils in bronchoalveolar lavage fluid increased in polymyxin B-treated animals when compared with those treated with saline. In addition, histological examination showed that the number of eosinophils infiltrated into the tracheal epithelium increased; injury to the tracheal epithelium was greater in polymyxin B-treated animals. The numbers of coughs induced by saline and each concentration of capsaicin (10^–18, 10^–16, 10^–14M) were greater in the polymyxin B-treated animals. FK-224 (a neurokinin receptor antagonist) decreased the heightened cough reflex in this animal model of eosinophilic bronchitis. These findings suggest that neuropeptides, and particularly neurokinins, are involved in the heightened cough receptor sensitivity in eosinophilic bronchitis without asthma. This has implications for better understanding of this disorder and its treatment.     

结节病5例的诊断

本文报告了5例结节病的临床、X线、CT表现,追踪了疾病的转归,重点描述了重型系统性结节病,提醒临床医师予以重视。     

Noonan syndrome associated with central giant cell granuloma

We report a case of Noonan syndrome associated with central giant cell granuloma. The patient was a 101/2-year-old boy with the chief complaint of proptosis of the right eye. He also had various malformations such as short stature, webbed neck, pectus excavatum, cubitus valgus, pulmonary valve stenosis and patent foramen ovale, a characteristic face appearance and cryptorchidism and so on. Chromosome analysis showed a 46, XY karyotype. A computed tomographic scan and magnetic resonance imaging showed a mass originated from the lateral wall of the right maxillary sinus. The patient underwent Caldwell-Luc operation. Histological examination of the mass showed the characteristics of central giant cell granuloma. This case report describes a patient with the features of the recently described Noonan-like/multiple giant cell lesion syndrome.     

骨嗜酸细胞肉芽肿的临床特征与治疗

目的探讨骨嗜酸细胞肉芽肿的临床表现、诊断和治疗效果。方法1991年3月至2006年3月收治骨嗜酸细胞肉芽肿28例,男19例,女9例;年龄1-61岁,平均22.4岁。病程20d～10个月。单发24例,多发4例。影像学表现为溶骨性改变,15例伴软组织肿物影。于外院确诊5例,入院后误诊为原发肿瘤及转移癌12例。所有病例均经病理学确诊。单发病例行化疗1例,手术治疗20例,手术后辅以放疗、化疗、激素综合治疗3例;多发病例采用放疗1例,激素治疗1例,综合治疗2例。结果全部病例随访7个月￣15年,平均5.3年。20例手术者手术治愈率100%;术后辅以放疗、化疗及激素治疗者无复发;植骨者6～12个月骨性愈合,随访功能不受限。1例行胸椎椎板减压术者截瘫部分恢复。4例多发病例中2例出现复发,再次给予激素及放疗、化疗后缓解。结论骨嗜酸细胞肉芽肿临床症状及影像学表现与肿瘤类似,误诊率极高。术前应尽可能行穿刺活检。对单发病例宜采用手术治疗,可辅以放疗或化疗;多发病例病灶多、范围广,不宜采用手术治疗,可选择放疗、化疗、激素治疗等综合疗法。