tRNA~(His/GUG)识别特性的分子力学模拟(英文)

本文选用经过实验验证的碱基序列 ,用简化的方式 ,构建了被水分子和镁离子修饰的核酸序列的分子模型 ,应用分子力学模拟方法对序列进行能量优化 ,对优化后序列的构象参数、成键状况和能量数据等进行了分析。对tRNAHHis GUG的识别特性作了初步的探索 ,得到了和实验结果相近的结论。此外 ,还从能力学的角度讨论了溶剂 -溶质 -溶剂相互作用形成的网状氢键网络对核酸结构稳定性的影响 ,探讨了非Crick_WatsonGU、UU配对的能力学特征并存在于被水分子和镁离子修饰的核酸序列中的GU、UU配对情况。     

The symptom of headache in Emergency Departments. The experience of a neurology emergency department

Although the symptom of headache is a frequent cause of Emergency Department examinations, it is often considered to be of little clinical relevance in comparison with other emergencies and is usually treated only symptomatically. But how frequently does a simple headache mask a severe cerebral pathology? To answer this question, we studied a consecutive series of patients examined at the Neurology Emergency Department of Turin's Ospedale Molinette over a period of three months; the patients were then followed-up for more than two years in order to confirm the diagnoses.Of 215 cases of acute headache, 121 (56%) were essential and 94 (44%) symptomatic; of the latter, 18 (8.3%) were the only clinical manifestation of a severe cerebral pathology (10 hemorrhages, 2 ischemias, 6 tumours). In diagnosing these 18 cases, 72 EEG, 57 CT and 4 rachicentesis examinations were carried out and their diagnostic efficacy is here analysed. Our data show the importance of a careful evaluation of the symptom of headache in Emergency Departments and the need to send any doubtful cases to a facility specialised in coping with such emergencies.

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Sommario Il sintomo cefalea costituisce un frequente motivo di visita in Pronto Soccorso, spesso considerato di scarsa rilevanza clinica rispetto ad altre urgenze e per lo più trattato solo dal punto di vista sintomatico. Ma in quanti di questi casi una semplice cefalea nasconde una grave patologia cerebrale? A questo proposito abbiamo effettuato uno studio presso il Dipartimento di Emergenza di Neurologia dell'Ospedale Molinette di Torino su una serie consecutiva di pazienti che sono stati visitati per cefalea nell'arco di tre mesi, seguendoli quindi nel tempo con un follow-up di oltre due anni per la verifica diagnostica.Su 215 cefalee acute, le cefalee essenziali sono risultate 121 (56%), e quelle sintomatiche 94 (44%). Tra queste ultime, 18 (8,3%) erano l'unica manifestazione clinica di una grave patologia cerebrale (10 emorragie, 2 ischemie, 6 tumori). Per diagnosticare questi 18 casi sono stati eseguiti 72 EEG, 57 T.C e 4 rachicentesi; di questi esami viene quindi analizzata l'efficacia ai fini diagnostici. Da questi dati emerge quindi l'importanza di un'attenta valutazione del sintomo cefalea in Pronto Soccorso e la necessità di inviare, nei casi dubbi, il paziente in una struttura specializzata per queste emergenze.

     

Interactive technology applications for behavioral counseling: issues and opportunities for health care settings

CONTENT: This article discusses the rationale for, and the potential benefits and limitations of, computer-based interactive health communication (IHC) programs for health behavior counseling. We describe common barriers to health behavior counseling in medical settings and show how IHCs can address these issues. Following an overview of current and likely near-future IHCs, the potential impact of IHCs on the patient-provider relationship is considered. Results from evaluations of IHCs are summarized and important and unique issues in evaluating IHCs are discussed. We conclude with recommendations for clinical applications, including recommendations for consumers considering purchase or adoption of IHCs and recommendations for future research.     

Report on the Computer Software Contest at 38th Congress of the Japan Society of Anesthesiology

We held a computer software contest at 38th Congress of the JSA, held in March, 1991. The aim is to encourage the members of the Society to write softwares and to help distribute them, especially as Freewares. We received 25 entries for the contest; two-thirds of these are for computers of NEC PC9801 series and a third are for Macintosh. We received donations 3 million yen worth of instruments and goods for prizes plus some cash, which as prizes were distributed to those who made entries for the contest.Most of these programs have been registered as freewares at various computer networks, including our Ether-Net, one of the common computer network SIGBBSs among Japanese anesthesiologists.(Suwa K, Miyasaka K, Tanaka Y, et al.: Report on the computer software contest at 38th congress of the Japan society of anesthesiology. J Anesth 5: 441–444, 1991)Executive Committee of the Computer Software Contest at 38th Congress of the Japan Society of Anesthesiology     

COMMENTS ON THE HOLISTIC ACTION OF ACUPUNCTURE IN VIEW OF ITS INFLUENCE ON NERVE-ENDOCRINE-IMMUNE NETWORK

In the present paper, the author makes some comments on the holistic action of acupuncture from the regulative effect on the nerve-endocrine-immune network, and the close relationship between the nerve-endocrineimmune network and the meridian-collateral system of TOM. The wholism concept of TOM refers to the organism being an integrated entirety, and the regulatory effect of acupuncture on functional activities of the organism relies on the integral connection of the acupoint--meridian-collateral-zangfu-organ system. When stimulated with acupuncture, the human body will brings its potential force into full play in preventing and treating diseases.     

集成技术在医院图书馆的应用

本文结合医院图书馆实际，采用系统集成及光驱虚拟技术，构建不同系统协同工作的网络环境，实现了多个系统功能的互通，提高了图书馆现代化管理水平及综合服务能力，解决了图书馆建设中存在的管理水平低、服务手段落后及数据库资源闲置浪费等问题。本技术对资金和技术人员紧缺的中小型医院图书馆实现网络共享光盘数据库具有现实意义。     

Mifepristone versus the Yuzpe regimen (PC4) for emergency contraception.

OBJECTIVE: To compare side effects, women's acceptance and satisfaction with mifepristone (100 mg) versus the Yuzpe regimen for emergency contraception (EC). METHODS: A total of 1000 women requesting EC within 72 h of unprotected intercourse were randomized to receive mifepristone 100 mg or the standard Yuzpe regimen. Outcome measures included patient acceptability and satisfaction. RESULTS: A total of 620 (62%) questionnaires were returned, 64% in the mifepristone group and 60% in the Yuzpe group. Mifepristone was better tolerated than the Yuzpe regimen. The rates of nausea (P<0.0001), abdominal pain (P=0.001), tiredness (P<0.0001), lethargy (P=0.001), hot flushes (P<0.0001) and dizziness (P<0.0001) were all significantly higher in women given the Yuzpe regimen compared to those who received mifepristone. Of these 94% and 80% in the mifepristone and Yuzpe groups, respectively, were satisfied with treatment (P<0.0001). Of women in the mifepristone group, 56% (181/321) had used the Yuzpe regimen of EC in the past and of these, 93.6% (161/172) indicated they would use mifepristone in the future. A total of four women in the Yuzpe group had mifepristone in the past and all four said they would use mifepristone in the future. CONCLUSION: Mifepristone has high patient acceptability and few side effects compared to the standard Yuzpe regimen for EC.     

医院网络与信息安全的问题和对策

随着医院信息化建设的发展，医院网络与信息安全得到了人们的重视。全文系统地阐述了医院网络与信息安全面临的各种问题，如网络设备可靠性、计算机病毒度非法入侵、内网安全、雷击和人为因素等，并提出了相应的对策。     

医院卫生材料库存核算信息管理系统

针对南京军区总医院耗材管理方面的特点,在综合原“医院设备器材管理信息系统”和“军字一号”系统相关功能模块的基础上,开发了“医院卫生材料库存核算信息管理系统”,实现了医院耗材采购和使用的一体化网络管理模式。论文详细介绍了材料库存核算信息管理系统的功能、工作流程及系统的体系结构、软件平台与相关的软件技术等。实际应用表明,该系统运行可靠稳定,有效提高了卫生材料成本核算的正确性及各科室的工作效率,并为领导提供了科学的决策依据。