浅谈医学技术给人类社会带来的不良影响

对现代医学技术给人类社会带来的各种不良影响进行了探讨,以期引起人们对该问题的重视,防止医学技术的滥用。     

基于数据挖掘技术名老中医经验传承的研究

名老中医的经验是我们宝贵的财富,但是现在却面临着流失的风险,介绍了数据挖掘的概念以及将数据挖掘的方法引入到名老中医经验传承中。为经验的传承提供了新的思路。     

MLL5基因敲除对小鼠结肠癌CT26细胞移植瘤生长的影响及其机制

目的：探讨混合谱系白血病5(MLL5)基因在小鼠结肠癌CT26细胞移植瘤生长中的作用及其分子机制。方法：利用CRISPR/Cas9技术构建MLL5基因缺失、MLL5和DDX58双基因缺失的结肠癌CT26细胞模型,用Sanger测序和WB法验证敲除效果。将基因敲除的CT26细胞接种到野生型BALB/c小鼠和免疫缺陷型NSG小鼠皮下,构建基因缺失结肠癌CT26细胞移植瘤小鼠模型,并观察移植瘤的生长及荷瘤小鼠的总生存期（OS）。结果：在野生型小鼠中,MLL5基因缺失的CT26细胞移植瘤生长速度显著性低于野生型癌细胞移植瘤,并延长荷瘤小鼠的OS(P<0.01);在NSG小鼠中,MLL5基因缺失对CT26细胞移植瘤的生长速度以及荷瘤小鼠的OS没有明显改变。MLL5基因缺失提高了癌细胞中视黄酸诱导基因1(RIG-1)蛋白水平,DDX58基因缺失可逆转MLL5基因缺失在CT26细胞移植瘤中的作用。结论：MLL5基因缺失可提高结肠癌CT26细胞中RIG-1蛋白水平、促进肿瘤免疫,从而抑制荷瘤小鼠肿瘤生长,提示MLL5可能成为结肠癌治疗的新靶点。     

应急救援专业技术网络教学平台应用研究

通过电子化学习技术(E-learning),将现有的网络资源和应急救援数字化教学培训相结合,充分利用现代信息技术所提供的全新沟通机制与丰富资源,为应急救援培训提供一个受众面更为广阔的平台,进一步为培训基地开展应急救援培训提供科学的、互动的、个性化的和不受时空约束的教学管理平台.该平台有利于各级人员根据自我需求制定各自的...     

银杏叶分散片生产工艺的研究

目的:确定银杏叶分散片的最佳生产工艺条件。方法:连续试生产3个批次的银杏叶分散片,并按照相关的质量标准对成品进行全面检验。结果:按照预定的生产工艺过程,可生产出质量稳定并符合标准的银杏叶分散片。结论:预定的工艺条件是可行的,适合制备银杏叶分散片。     

Combining a digital design-mediated surgery-first approach and clear aligners to treat a skeletal Class III defect for aesthetic purposes: a case report

This case report introduces digital surgery-first approach orthognathic surgery assisted by three-dimensional virtual planning and combined with invisible orthodontic treatment for a 21-year-old female patient with a skeletal Class III high-angle gummy smile malocclusion. We explored the clinical significance of the widespread application of digital technology for rapid development of the orthodontic/orthognathic field. The regional acceleratory phenomenon and clear aligners were used to achieve fast and aesthetic tooth movement after surgery. The treatment lasted only 8 months, and the patient was satisfied with the aesthetic results. The results remained stable after 1 year of follow-up. This case report highlights the advantages of combining a digital design and a surgery-first approach to produce accurate, rapid, safe, stable, and fulfilling cosmetic results. The combination of the surgery-first approach and clear aligners can facilitate patient-oriented surgical orthodontic treatment.     

Adhesive Joints of Additively Manufactured Adherends: Ultrasonic Evaluation of Adhesion Strength

Adhesive joints are widely used in the construction of machines and motor vehicles. Manufacturers replace them with the welding and spot-welding methods due to the lack of damage to the material structure in the joint area. Moreover, it is aimed at reducing the weight of vehicles and producing elements with complex shapes. Therefore, additive manufacturing technology has been increasingly used in the production stage. This fact has not only changed the view on the possibilities of further development of the production technology itself, but it has also caused an intense interest among a greater number of companies in the advantages of structural optimization. There is a natural relationship between these two areas in the design and production, allowing for almost unlimited possibilities of designing new products. The main goal of the research described in this article was to determine the correlation between the strength of the adhesive joint of elements produced using additive technology and the parameters of the ultrasonic wave propagating in the area of the adhesive bond. The tests were carried out on samples made of AlSiMg0.6 material and a structural adhesive. Strength tests were performed to determine the shear force which damaged the joint. Furthermore, an ultrasonic echo technique enabling the determination of a nondestructive measure of the quality and strength of the joint was developed. The samples of the adhesive joints had a strength of about 18.75–28.95 MPa, which corresponded to an ultrasonic measure range of 4.6–7.8 dB. The determined regression relationship had a coefficient of determination at the level of 0.94. Additional ultrasonic tests of materials made with the additive technology confirmed its different acoustic properties in relation to aluminum produced with the standard casting or extrusion process. Designated dependence combining the mechanical strength and the decibel difference between the first and second impulses from the bottom of the joint may constitute the basis for the development of a nondestructive technique for testing the strength of adhesive joints.     

子宫内膜增生症及早期子宫内膜癌保留生育功能后冻胚移植妊娠结局

目的 探讨子宫内膜复杂性增生/不典型增生/早期子宫内膜癌保留生育力治疗后冻胚移植子宫内膜准备方案对妊娠结局的影响。方法 回顾性分析2015年1月至2020年12月于山东大学附属生殖医院门诊经体外受精或卵细胞质内单精子注射行冻胚移植的经保留生育功能治疗后逆转的子宫内膜复杂性增生/不典型增生/早期子宫内膜癌患者的临床资料,纳入了112例患者的179个冻胚移植周期,按冻胚移植子宫内膜准备方案分为4组：自然周期组(n=29)、促排卵周期组(n=38)、直接替代周期组(n=89)、降调+替代周期组(n=23)。比较分析各组的临床特征和妊娠结局,采用二分类Logistic回归分析影响患者活产率的因素。结果 在179个周期中,促排卵周期组与自然周期组、直接替代周期组和降调+替代周期组比较,其妊娠周期活产率(34.2%、31.0%、31.5%、30.4%)、活产率(46.7%、31.8%、34.8%、22.2%)、妊娠周期临床妊娠率(52.6%、37.9%、49.4%、43.5%)、妊娠周期生化妊娠率(65.8%、44.8%、64.0%、47.8%)更高,自然周期组妊娠周期流产率低于其他3组(18.2...     

基于ICT的虚拟社区活动与教师专业发展

随着信息通讯技术（ICT）的迅猛发展,虚拟社区的概念及其研究领域应运而生,并成为教育学习的重要空间和平台。基于ICT的虚拟社区将成为教师专业发展的重要舞台,成为教师超越时间和地域限制,相互联系、相互学习、协作共进的新方式。     

医学影像交班系统应用效果分析

设计开发骨科适用的医学影像交班系统,采用调查问卷方式比较影像交班和传统手工书写交班方式,评估系统应用效果,结果表明该系统能够提高专科信息化管理水平。