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21.
The respiratory-dependent pacemaker (RDP3 or MB-1, Biorate, Biotec International, S.p.A., Bologna, Italy) detects the respiratory rate by measuring thoracic impedance using a subcutaneous auxiliary lead. The sensed respiratory rate is used to determine the pacing rate response. This pacemaker had been implanted in 9 patients with a mean age of 58 (range 42-69) years. During symptom-limited treadmill exercise, rate-modulated pacing resulted in a significant increase in pacing rate (mean +/- SD, 124 +/- 10 vs. 71 +/- 3 beats/min p less than 0.001) and exercise capacity (343 +/- 147 vs. 463 +/- 120 s, p less than 0.05) compared to those achieved with constant rate ventricular pacing. Brief treadmill exercise tests showed appropriate rate response to increased walking speed and gradient. However, rate response was modified by arm swinging-induced motion artefact which affected the measured "impedance." Complications observed on follow-up included perforation of the auxiliary lead in 2 patients and symptomatic myopotential interference in 3 patients with the RDP3 pacemaker, all of whom required unit replacement. It is concluded that although the respiratory-dependent pacemaker can confer physiological benefit in patients with bradycardia, myopotential interference (largely overcome by the new version MB-1 with programmable sensitivity) and the auxiliary lead can be problematic in some patients. 相似文献
22.
PAOLO ALBONI NELLY PAPARELLA RICCARDO CAPPATO PAOLO PEDRONI GIAN CARLO CANDINI GIAN ENRICO ANTONIOLI 《Pacing and clinical electrophysiology : PACE》1989,12(2):294-300
The purpose of this study was to find out whether transesophageal pacing could be utilized for assessment of sinus node function in patients with sick sinus syndrome (SSS). In 17 patients with SSS (study group) we compared the results of sinus node tests obtained both in the basal state and after pharmacological autonomic blockade by endocavitary stimulation and, 24 hours later, by transesophageal pacing. In another group of 17 patients with SSS (control group), we compared the results obtained by two endocavitary studies. In "study group", sinus cycle length (SCL) and corrected sinus node recovery time (CSRT) did not show significant differences between the two studies both in the basal state and after autonomic blockade, whereas sinoatrial conduction time (SACT) was more prolonged during esophageal pacing (P less than 0.01). In "control group", sinus node measures did not show significant differences between the two studies. In the "study group," the following coefficients of correlation were obtained in the basal state; SCL, r = 0.65, CSRT, r = 0.57, SACT, r = 0.52 and after autonomic blockade: SCL, r = 0.95, CSRT, r = 0.62 and SACT, r = 0.53. In the basal state, the correlation for SCL and CSRT between the two studies was lower in the "study group" than in the "control group" (P less than 0.05), whereas after autonomic blockade the correlation for sinus node measures did not show significant differences between the two groups of patients. These data suggest that transesophageal study influences the autonomic tone regulating the sinus node; however, it is not responsible for important variations in sinus node measures.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
23.
Dr M. Kimura T. Sugiura Y. Fukui T. Kimura Y. Harada 《Medical & biological engineering & computing》1992,30(2):155-161
Two ways of rate control for diaphragm pacing are proposed. One is rate control using only the patients' body temperature
(method I). The other is rate control by both the patients' heart rate and body temperature (method II). To test the effectiveness
of these methods, a diaphragm pacemaker which can be controlled by both heart rate and body temperature has been developed.
It was applied to nine mongrel dogs. The pacing rate is controlled by atrial blood temperature (method I) or by both heart
rate and temperature (method II). The animal's metabolism was elevated by the administration of a pyrogenic drug. It was found
that method I is not suited to rapid changes in metabolism; however, it is useful in extreme metabolic elevation. An animal's
metabolism was supported by using method II in all ranges of metabolism. This method proved more effective than method I for
rate-responsive diaphragm pacing. 相似文献
24.
Simultaneous electrical stimulation of tissue with the measurement of blood flow using an electromagnetic flowmeter system
almost invariably results in large flow measurement inaccuracies. These inaccuracies are because the electrical energy from
stimulating artefacts is amplified along with the flow signals. The paper describes the building and use of an inexpensive
circuit to remove stimulation artefacts from electromagnetic flow measurements. 相似文献
25.
J
RGEN THORVALDSON ARNFINN ILEBEKK SEVERIN LERAAND FREDRIK KIIL 《Acta physiologica (Oxford, England)》1984,121(1):45-56
To examine the effects of pulmonary vascular pressures and flow on pulmonary blood volume (PBV), experiments were performed at constant heart rate and zone 3 conditions (mean left atrial pressure (LAP) above airway pressure) in six anesthetized, open-chest dogs. PBV was calculated as the product of electromagnetic aortic flow and pulmonary mean transit time for ascorbate, obtained without blood withdrawal by polarographic recording of aortic ascorbate changes. In three series of experiments LAP was raised similarly in three steps, from 4.5 to 14.8 mmHg: by mitral constriction which reduced pulmonary blood flow, by blood volume expansion which more than doubled pulmonary blood flow, or by a combination of the two procedures which kept pulmonary blood flow constant. In all three series, LAP and mean pulmonary arterial pressure (PAP) rose in proportion, but PBV was better correlated to PAP (r=0.87±0.02) than to LAP (r=0.66±0.09). These experiments suggest that PAP is the most important factor in determining PBV under zone 3 conditions, whether PAP is raised by increasing pulmonary blood flow or by mitral constriction. 相似文献
26.
An Investigation into the Electrical Ablation Technique and a Method of Electrode Assessment 总被引:1,自引:0,他引:1
Ablative techniques, using standard defibrillators and commonly available cardiac catheters, have been applied to the His bundle and bypass tracts for the management of arrhythmias. We have done in vitro studies of the physical effects of these high energy electrical impulses delivered via different pacing electrodes. Unipolar impulses of 10 to 400 joules were delivered via three U.S.C.I. bipolar electrodes and three Vitatron Helifix electrodes immersed in Ringer's solution. The effects were recorded on 35 mm still film, video tape, and high speed cine film. Pressure, voltage, and current were measured. The U.S.C.I. bipolar electrodes and the Vitatron Helifix electrodes safely withstood repeated delivery of 400-joule impulses which produced similar flash shapes. Each took the form of an incandescent, spherical "fire-ball" centered around the exposed electrode surface. The mean diameters of the "fire-ball" for 10 to 400 J using the U.S.C.I. electrodes were 5-24 mm and 3-20 mm for the Helifix catheter electrodes. Peak pressure excursions of over an atmosphere were observed 3 cm from the electrode tips. Higher pressures, lower voltages, and larger currents occurred using the U.S.C.I. pacing lead. The simple, 35 mm time exposure technique showed that at low energies the flashes appeared to emerge in a retrograde manner from the U.S.C.I. catheters and more distally from the Helifix electrode. This suggested that the latter might be more effective with lower energy impulses. It is concluded that lower energies should be used to take full advantage of the active fixation electrode. 相似文献
27.
Atrial pacing in the management of sick sinus syndrome: Long-term observation for conduction disturbances and supraventricular tachyarrhythmias 总被引:1,自引:0,他引:1
Atrial pacing (AAI) in sick sinus syndrome (SSS) has been questionedbecause of the risk of distal conduction disturbances (DCD)and atrial tachyarrhythmias. The authors studied the incidenceof clinically relevant DCD and arrhythmias in 52 SSS patientswith AAI. The observation time was 2567 (mean 48) months. Invasive electrophysiologic investigation was performed preoperativelyin 29 cases and preoperative atrial pacing to Wenckebach blockor to 150 ppm in 23. The preoperative investigation showed prolongedHV-time in three cases and Wenckebach block at 110ppm in onecase, while six patients had LAH-block, five RBB-block and twofirst degree A V-block. No further DCD developed in any of thesepatients. Second-degree type IA V-block developed in two patientsafter 2 and 19 months, respectively. One had been treated withdigitalis and verapamil and was asymptomatic. The other patient,who had a low ventricular rate, experienced near-syncope. Thesetwo blocks could not be predicted from the preoperative andperoperative investigations. In five patients (10%) permanent atrial fibrillation developedduring the follow-up period. The incidence of concomitant supraventriculartachyarrhythmias in the patients with the bradycardia-tachycardiasyndrome appeared to be unaffected by the pacemaker treatment. 相似文献
28.
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30.
T. Cochrane A. W. Nathan R. S. Bexton C. Callicott R. A. J. Spurrell A. J. Camm 《Medical & biological engineering & computing》1984,22(1):19-23
A microcomputer-based pacemaker system for the evaluation of pacemaker treatment of tachycardia is described. The system may
be used to study tachycardia initiation, tachycardia termination or a combination of the two. The software incorporates a
visual display unit screen handling package which provides the user-system interface. System-patient interfacing is performed
by a separate pacing and sensing unit which communicates with the computer via standard digital input/output lines. Several
pacing options are available, selectable from a screen-displayed menu. Each selection also has an associated set of programmable
parameters which may be adjusted, within allowed limits, to suit particular studies. Examples of the use of the system for
tachycardia termination are given. The main programming language for the controlling software was Fortran IV. Some routines
were necessarily written in assembly language. The system is useful for evaluation purposes and forms the basis of a cardiac
pacemaker development tool. 相似文献