2003中国生物医学电子学学术年会综述

本文介绍了2003年中国生物医学电子学学术年会(CBME′03)会议的概况，并根据学术年会上的大会报告和分组报告，以及论文集内容，对我国生物医学工程学学科发展动向作了分析。     

Journey from conference presentation to peer-reviewed publication: Do ends really meet?

Introduction

The National Conference (NATCON) of Anatomical Society of India (ASI) is the preeminent meeting of anatomists in South-east Asia region. In the present study we undertook a quantitative assessment of the abstracts presented orally in three NATCON of ASI held between 2013 and 2015, with regards to rate of subsequent publication in peer reviewed journals.

Flatworm models in pharmacological research: The importance of compound stability testing

Flatworms possess adult pluripotent stem cells, which make them extraordinary experimental model organisms to assess in vivo the undesirable effects of substances on stem cells. Currently, quality practices, implying evaluation of the stability of the test compound under the proposed experimental conditions, are uncommon in this research field. Nevertheless, performing a stability study during the rational design of in vivo assay protocols will result in more reliable assay results. To illustrate the influence of the stability of the test substance on the final experimental outcome, we performed a short-term International Conference on Harmonization (ICH)-based stability study of cyclophosphamide in the culture medium, to which a marine flatworm model Macrostomum lignano is exposed. Using a validated U(H)PLC method, it was demonstrated that the cyclophosphamide concentration in the culture medium at 20 °C is lowered to 80% of the initial concentration after 21 days. The multiwell plates, flatworms and diatoms, as well as light exposure, did not influence significantly the cyclophosphamide concentration in the medium. The results of the stability study have practical implications on the experimental set-up of the carcinogenicity assay like the frequency of medium renewal. This case study demonstrates the benefits of applying appropriate quality guidelines already during fundamental research increasing the credibility of the results.     

Farm Equipment-Motor Vehicle Crash Prevention Conference (FEMVCPC)

ABSTRACT

This plenary talk at the eighth annual Midwest Rural Agricultural Safety and Health Forum, November 2009, described a conference held earlier in the year focusing on the hazards and risks associated with moving agricultural equipment on public roads. The Farm Equipment-Motor Vehicle Crash Prevention Conference (FEMVCPC), March 2009, Des Moines, Iowa, drew 54 participants representing 13 states for presentations and discussions. Data showing that over 1100 farm equipment-motor vehicle crashes occur annually in the Great Plains Center for Agricultural Health's nine-state region document agricultural producer stated concerns. The conference format allowed for presentations from a wide range of perspectives and provided discussion time for caucusing at two levels. The first level involved caucus by specialty (e.g., state agencies, sheriff/highway patrol, driver educators, farmers, retailers/manufacturers). The second level caucuses gathered individuals from their respective states to consider what is being done and what could be done relative to each area identified in the first level caucuses. The final product of the conference was a specific action plan each state group would advocate and bring forward in their state. On-site and 6-month follow-up evaluations with each state group indicated that the conference content increased participant knowledge and provided them with new content to use in current and future state programs. As important is the finding that participants have used conference content to foster interest, new collaborations, and specific project planning related to agricultural roadway transportation issues.     

Characterization of size, structure and purity of serogroup X Neisseria meningitidis polysaccharide, and development of an assay for quantification of human antibodies

Serogroup X Neisseria meningitidis (MenX) has recently emerged as a cause of localized disease outbreaks in sub-Saharan Africa. In order to prepare for vaccine development, MenX polysaccharide (MenX PS) was purified by standard methods and analyzed for identity and structure by NMR spectroscopy. This study presents the first full assignment of the structure of the MenX PS using (13)C, (1)H and (31)P NMR spectroscopy and total correlation spectroscopy (TOCSY) and (1)H-(13)C heteronuclear single quantum coherence (HSQC). Molecular size distribution analysis using HPLC-SEC with multi-angle laser light scattering (MALLS) found the single peak of MenX PS to have a weight-average molar mass of 247,000g/mol, slightly higher than a reference preparation of purified serogroup C meningococcal polysaccharide. MenX PS tended to be more thermostable than serogroup A PS. A method for the quantification of MenX PS was developed by use of high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD). A novel and specific ELISA assay for quantification of human anti-MenX PS IgG based on covalent linkage of the MenX PS to functionally modified microtitre plates was developed and found valid for the assessment of the specific antibody concentrations produced in response to MenX vaccination or natural infection. The current work thus provides the necessary background for the development of a MenX PS-based vaccine to prevent meningococcal infection caused by bacteria bearing this capsule.     

《中国药学》（英文版）参加中国高校科技期刊研究会第十八次年会并获奖

第五届中国高校精品·优秀·特色科技期刊奖颁奖大会暨第十八次年会于11月11–12日在广州市隆重召开。来自全国高校科技期刊编辑出版单位的400余名代表参加了颁奖大会。出席会议的领导和嘉宾有：中宣部出版局刘建生副局长、教育部科技司高润生副司长、科技部原主管科技期刊工作的宋培元处长、教育部科技司综合处李人杰和王万鹏等。佟建国副理事长首先作了关于评比工作总结的报告,随后李人杰宣读了教育部科技司关于公布评比结果的通知,此届评比有精品期刊奖、优秀期刊奖、特色期刊奖。     

Fifteen years after the International Conference on Population and Development: What have we achieved and how do we move forward?

This article surveys the current situation and prospects for attaining the goals set by the International Conference on Population and Development (ICPD) held in 1994, and the health-related Millennium Development Goals (MDGs), set in 2000. Encouraging changes in the policy environment are highlighted, but the available resources do not yet match needs. Global maternal mortality figures, at over 500 000 a year, have not changed since 1990, and morbidity is about 20 million. Some countries have made progress with low-cost, high-yield interventions such as family planning, skilled birth attendants, access to emergency obstetric and neonatal care, management of sexually transmitted infections, and HIV prevention. However, progress in many low-income countries has been slow, and few are on track to meet the goals. There are wide inequities in care among and within countries. Suggestions for priority attention are offered, such as a “continuum of care” approach, integrated services, and comprehensive policies on human resources for health.