首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   12253篇
  免费   1106篇
  国内免费   295篇
耳鼻咽喉   97篇
儿科学   170篇
妇产科学   362篇
基础医学   306篇
口腔科学   65篇
临床医学   1209篇
内科学   1159篇
皮肤病学   31篇
神经病学   253篇
特种医学   273篇
外国民族医学   1篇
外科学   1041篇
综合类   1639篇
预防医学   422篇
眼科学   41篇
药学   1376篇
  10篇
中国医学   371篇
肿瘤学   4828篇
  2024年   19篇
  2023年   103篇
  2022年   305篇
  2021年   419篇
  2020年   356篇
  2019年   330篇
  2018年   394篇
  2017年   419篇
  2016年   457篇
  2015年   441篇
  2014年   979篇
  2013年   832篇
  2012年   846篇
  2011年   967篇
  2010年   772篇
  2009年   801篇
  2008年   748篇
  2007年   685篇
  2006年   606篇
  2005年   457篇
  2004年   338篇
  2003年   352篇
  2002年   254篇
  2001年   283篇
  2000年   235篇
  1999年   217篇
  1998年   144篇
  1997年   127篇
  1996年   107篇
  1995年   123篇
  1994年   71篇
  1993年   75篇
  1992年   40篇
  1991年   42篇
  1990年   32篇
  1989年   21篇
  1988年   24篇
  1987年   22篇
  1986年   19篇
  1985年   39篇
  1984年   33篇
  1983年   17篇
  1982年   24篇
  1981年   17篇
  1980年   22篇
  1979年   26篇
  1978年   7篇
  1977年   5篇
  1976年   2篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
141.
AimImproving survival for women with early breast cancer (eBC) requires greater attention to the consequences of treatment, including risk to ovarian function. We have assessed whether biochemical markers of the ovarian reserve might improve prediction of chemotherapy related amenorrhoea.MethodsWomen (n = 59, mean age 42.6 years [(range 23.3–52.5]) with eBC were recruited before any treatment. Pretreatment ovarian reserve markers (anti-Müllerian hormone [AMH], follicle-stimulating hormone [FSH], inhibin B) were analysed in relation to ovarian status at 2 years.ResultsPretreatment AMH was significantly lower in women with amenorrhoea at 2 years (4.0 ± 0.9 pmol/L versus 17.2 ± 2.5, P < 0.0001), but FSH and inhibin B did not differ between groups. By logistic regression, pretreatment AMH, but not age, FSH or inhibin B, was an independent predictor of ovarian status at 2 years (P = 0.005; odds ratio 0.013). We combined these data with a similar cohort (combined n = 75); receiver–operator characteristic analysis for AMH gave area under curve (AUC) of 0.90 (95% confidence interval (CI) 0.82–0.97)). A cross-validated classification tree analysis resulted in a binary classification schema with sensitivity 98.2% and specificity 80.0% for correct classification of amenorrhoea.ConclusionPretreatment AMH is a useful predictor of long term post chemotherapy loss of ovarian function in women with eBC, adding significantly to the only previously established individualising predictor, i.e. age. AMH measurement may assist decision-making regarding treatment options and fertility preservation procedures.  相似文献   
142.
143.
144.
邢冬婕 《护士进修杂志》2014,(18):1712-1715
目的 开发乳腺癌经外周静脉置入中心静脉导管(PICC)化疗患者自我管理行为测评量表,并进行效度和信度检验。方法 参考美国斯坦福大学患者教育研究中心Dr.Kate.Lorig等创建的《慢性病自我管理研究测量表》及其评分标准,结合乳腺癌PICC患者自我管理内容,经参考文献、专家评定,修订成《乳腺癌PICC化疗患者自我管理行为测评量表》。量表包括5个维度,19项量化指标,共78个条目。192例乳腺癌PICC化疗患者参加了调查。结果 有效问卷178份,量表的内容效度指数(CVI)为0.906,总体Cronbach’α系数为0.892。采用因子分析法,提取出特征根大于1的公因子4个,解释总方差的41.180%,每个条目在相应因子上的负荷均在0.3以上。结论此测评量表具有较好的效度和信度,为研究者提供了乳腺癌PICC化疗患者自我管理行为评价和干预的工具。  相似文献   
145.
According to the NIH, about 275 000 patients receive treatment with 5-Fluorouracil (5-FU) and more than 1300 die from 5-FU toxicity every year from life-threatening myelosuppression, gastrointestinal complications, and neurotoxicity. Immunocompromised persons are at higher risk of developing toxicity. Recently uridine triacetate (Vistagard®) has been approved by the Food and Drug Administration (FDA) as the only specific antidote available for 5-FU poisoning. In a clinical trial (n = 135), 96% of patients with 5-FU toxicity recovered after treatment, where as in a historical control group only 10% survived. This is the first published case report of survival after 5-FU overdose who also was immunocompromised from HIV/AIDs. A 52 year old male with history of HIV/AIDS (CD4 70), CNS toxoplasmosis and anal cancer presented to the emergency department after realizing he had received an entire course of 5-FU in 24 instead of 96 h. Treatment with uridine triacetate was arranged in the emergency department. After receiving treatment the patient was asymptomatic and had an uncomplicated hospital course. 5-FU poisoning must be recognized early as uridine triacetate is approved by the FDA for use within 96 h following the end of 5-FU administration. Emergency medicine physicians should promptly recognize and treat 5-FU poisoning. However, this may be challenging as patients may not seek medical attention until many hours or several days after last administration since symptoms are often delayed with 5-FU poisoning.  相似文献   
146.
147.
148.
Cholangiocarcinoma can arise in all parts of the biliary tract and this has implications for therapy. Surgery is the mainstay of therapy however local relapse is a major problem. Therefore, adjuvant treatment with chemoradiotherapy was tested in trials. The SWOG-S0809 trial regimen of chemoradiotherapy which was tested in extrahepatic cholangiocarcinoma and in gallbladder cancer can currently be regarded as highest level of evidence for this indication. In contrast to adjuvant therapy where only conventionally fractionated radiotherapy plays a role, stereotactic body radiotherapy (SBRT) today has become a powerful alternative to chemoradiotherapy for definitive treatment due to the ability to administer higher doses of radiotherapy to improve local control. Sequential combinations with chemotherapy are also frequently employed. Nevertheless, in general cholangiocarcinoma is an orphan disease and future clinical trials will have to improve the available level of evidence.  相似文献   
149.
Neuroblastoma is a common tumor of children. We report a patient with extensive calvarial metastases of a neuroblastoma as an initial presentation. A 2-year-old girl presented with a history of gradually increasing head size and fever. A brain CT showed a multilobulated, large, extra-axial tumor involving both frontotemporoparietal areas with a sunray-spiculated hyperostosis of the skull and marked contrast enhancement. A brain MRI demonstrated extensive calvarial lesions with simultaneous involvement of the orbits. A biopsy was performed and a ganglioneuroblastoma was diagnosed. On systemic evaluation, an enlarged abdominal mass was detected. After neo-adjuvant chemotherapy, most of the tumors disappeared except for a tumor in the left parietal area; there was a corresponding decrease in the circumference of the head. We performed surgery for the remnant mass. Intensive chemotherapy was administered and a bone marrow transplantation was performed. Adequate neo-adjuvant chemotherapy followed by surgery to the neuroblatoma with extensive metastases to the skull and orbit may be helpful.  相似文献   
150.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号