喜树中两个DNA拓扑异构酶Ⅰ抑制剂

目的：以生物活性为向导在喜树中寻找天然的DNA拓扑异构酶Ⅰ抑制剂。方法：用各种层析方法和波谱方法从喜树中分离并鉴定了14个化合物。结果：其结构分别鉴定为喜树碱(1)，肌醇(2)，喜果苷(3)，3’甲基3，4O，O-亚甲基鞣花酸-4’-D-β-D-吡喃葡萄糖苷(4)，2-氧-1，2-二氢．喹啉4酸(5)，马钱子酸(6)，4-甲基-1，2-环己烷二甲醇(7)，strictosamide(8)，獐芽菜苷(9)，乙酰胺(10)，氯原酸(11)，strictosidinic acid(12)，1-咖啡酰基奎宁酸(13)和10-羟基喜树碱(14)。结论：化合物4-13为首次从该植物中分得，化合物4的核磁数据在文献中有误，本文对其进行了重新归属。经体外活性测试，化合物1对DNA拓扑异构酶Ⅰ有中等程度的抑制作用，化合物4，14对DNA拓扑异构酶Ⅰ有强的抑制作用。     

化工工人肌肉骨骼功能及其与工作能力的关系

目的 研究化工工人肌肉骨骼功能状况及其与工作能力的关系。方法 对101名化工作业工人进行肌肉骨骼功能(背肌耐力、手握力、躯干柔韧性、腹肌力和肌肉骨骼功能指数)测定和工作能力指数(wAI)测定。结果男性握力显著高于女性(P＜O.01)，腹肌力、背肌耐力和肌肉骨骼功能指数(MSFI)均男性较高，躯干柔韧性女性较高；年龄与MSFI呈负相关(r=O．489，P＜O．01)，随年龄增加，肌肉骨骼功能下降；不同劳动类型化工职工肌肉骨骼功能差异无显著性；肌肉骨骼功能与工作能力之间存在密切的关系，MSFI与WAI的相关系数为O.215(P＜O．05)，MSFI分级和WAI分级间有较好的一致性，完全一致率为56．7％。结论 肌肉骨骼功能的测定对于评价化工工人工作能力可能具有重要的意义。     

CT图像中噪声产生机理与维修

本文重点阐述和分析了CT图像中的几种噪声产生的原因和对图像的影响,并结合笔者多年的维修经验,从理论和实际相结合,介绍了几种实用的维修方法,提出了减小噪声提高图像质量的有效措施。     

Chemical shift imaging spectroscopy and memory function in temporal lobe epilepsy

PURPOSE: Hippocampal neuron loss and associated memory deficits are characteristic of intractable temporal lobe epilepsy (TLE). Proton chemical shift imaging (CSI) spectroscopy is a sensitive tool for detecting neuronal loss. The aim of this study was to investigate the correlation between memory functions and results provided by CSI spectroscopy of the hippocampal structures. METHODS: Ten patients with cryptogenic TLE participated. The study protocol involved both the acquisition of high-spatial-resolution CSI spectroscopy and neuropsychological evaluation, including memory testing and intracarotid sodium amytal test (IAT). The analysis of the CSI data was based on normative data obtained in 30 healthy volunteers. Memory functions were represented by verbal, visual, and general memory indices. RESULTS: A significant correlation was found between CSI spectroscopy of the hippocampal formation and the verbal memory indices for the dominant hemisphere. In addition, there was a significant correspondence of the qualitative judgment "hippocampal pathology indicated by CSI spectroscopy" and both "material specific memory deficit" and "memory deficit in the IAT." CONCLUSIONS: Our results demonstrate that CSI spectroscopy of the hippocampal structures is strongly related to lateralized memory deficits in patients with TLE. This suggests that CSI spectroscopy may be useful in the prediction of postoperative outcome in respect of seizure control and memory.     

Evaluation of a spinal needle locking device for use with the combined spinal epidural technique

Success of the 'needle-through-needle' technique for combined spinal epidural analgesia requires the immobilisation of the spinal needle during intrathecal injection. A device that achieves this was evaluated in 200 labouring women, randomly allocated to receive a combined spinal epidural using the CSEcure(R) (SIMS Portex, UK) locking needle or a conventional, non-locking technique. Data collection included the incidence of dural click as the spinal needle penetrated the dura mater, presence of cerebrospinal fluid in the spinal needle hub and the number of technical failures with the spinal component. Successful dural punctures with the spinal needle were similar for locking and non-locking needles (99.0 vs. 98.0%; p = 0.55), despite a small but significant reduction in dural click with the locking needle compared with the non-locking technique (97. 0 vs. 84.7%; p < 0.01). Although not statistically significant, there was a higher number of technical failures, mainly due to spinal needle movement, in the non-locking group (9.1 vs. 3.1%; p = 0.08). The locking needle device may be a useful alternative to conventional methods for combined spinal epidural analgesia.     

Parapharyngeal space lipoma

I ipomas of the Para-pharyngeal space are rare lesions Very few cases of such tumors have be en reported in the literature Definitive diagnosis and decision regarding the surgical approach Here difficult in the pre CT scan era This was further compounded by the complex anatomy of the Para pharyngeal space A case of Para pharyngeal lipoma is being presented because of its ratity and characteristic radiological features After confirmation of the diagnosis the tumor was excised via a transcertical approach     

咽旁间隙肿瘤的手术治疗

目的：探讨咽旁间隙肿瘤的诊断、治疗和手术入路的选择。方法：回顾性分析接受手术治疗的34例咽旁间隙肿瘤患者的临床资料，包括症状、体征、组织学诊断、影像学检查和手术进路。结果：88．2％肿瘤为良性。16例起源于腮腺，神经源性肿瘤14例。颈侧进路26例；经口腔进路5例，颈侧及口咽联合进路2例；颞下窝入路1例。32例完全切除肿瘤。术后并发Horner综合征3例，声带麻痹5例，面瘫3例。术侧声带和舌下神经同时麻痹1例。随访13个月～10．5年，34例中30例治愈，1例好转，术后复发3例(均为多形性腺瘤)。结论：采用颈侧进路，能安全彻底切除咽旁间隙肿瘤，经口腔进路仅适合于肿瘤边界清楚、组织明显突出于咽侧且表浅局限者。     

唇挡治疗乳牙早失间隙缩窄的临床应用

目的：探讨唇挡在乳牙早失间隙缩窄病例中的恢复间隙作用.方法：选取混合牙列时期下颌双侧第二乳磨牙早失,第一恒磨牙近中倾斜缺牙间隙缩窄病例20例.制作唇挡.一个月复诊以加力扩弓,测量间隙变化.结果：经唇挡坚持戴用9个月以上者,第一恒磨牙直立或远中移位,间隙得到恢复.平均戴用13.4个月,间隙平均增加了2.46 mm.结论：唇挡制作简单,便于操作,能够快速扩大下颌牙弓,是混合牙列时期恢复乳牙早失间隙缩窄的有效方法.     

一个快速的多维数据包分类算法

通过引入位图映射以及元组空间的概念,提出了一个数据包分类算法,该算法可以满足高性能网络对骨干路由器的要求,能够以线速完成对输入数据包的分类处理。算法在时间及空间复杂度上性能较好,并具有很好的扩展性。     

几种为Authorware制作的CAI课件节省磁盘空间的方法

文章结合实践介绍了在应用Authorware制作CAI课件时,通过采用对媒体素材的压缩、程序方面的压缩和文件发布及安装时的压缩等操作,使课件“减肥”,以达到节省磁盘空间的几种措施和方法。