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151.
This study is aimed at detecting gastrointestinal sounds (GIS) and correlating their characteristics with gastrointestinal
(GI) conditions. The central hypotheses are that GIS generation depends on the motility patterns and the mechanical properties
of the gut, and that changes in those result in measurable differences in GIS. An animal model which included both healthy
rats and those with small bowel obstruction (SBO) was developed. The acoustic bursts, of GIS were detected by amplitude thresholding
the signal envelope. Three methods of envelope estimation were proposed and evaluated. Envelope estimation using a Hilbert
transform was found to produce the best results in the current application. The duration and dominant frequency of each detected
GIS event was estimated and clear differences between healthy and diseased rats were discovered. In the control state, GIS
events were found to consistently be of relatively short duration (3–65ms). Although the majority of events in the SBO state
had similar short duration, infrequent longer events were also detected and appeared to be pathognomonic. Long duration events
(>100 ms) occurred in each of seven obstructed, but in none of 14 non-obstructed, cases (p<0.001). It is concluded that GIS
analysis may prove useful in the non-invasive, rapid, and accurate diagnosis of SBO. 相似文献
152.
M G Tordoff 《Physiology & behavior》1985,35(3):455-463
Rats that were neonatally sympathectomized with guanethidine (GUA) and given access to a four-component supermarket diet (SD) when either adolescent or adult gained weight at the same rate as controls. Adrenodemedullation (MDL) of adults, either alone or in combination with GUA treatment, also failed to influence the development of dietary obesity. Neonatal sympathectomy induced small changes in caloric consumption and diet preferences. These results question the notion that the sympathetic nervous system (SNS) is an essential contributor to the control of body weight and the development of dietary obesity. 相似文献
153.
本文分别应用标准12导联系统,Frank正交导联系统和改良Frank正交导联系统记录健康人36例、陈旧性心肌梗塞42例的心室碎裂电位,通过分析这些导联系统中相互垂直或近似垂直的导联上VFP的形态,数量关系,发现改良Frank正导联系统记录VFP较其它导联系统更科学,合理,且操作方便。 相似文献
154.
Richard S. Surwit Marilyn N. Bradner Cynthia H. Fenton Robert N. Pilon 《Psychophysiology》1978,15(4):320-323
The purpose of the present study was to assess the relationship between lateralization of body image and right versus left vasomotor activity. Fifteen right-handed female patients suffering from idiopathic Raynaud's disease demonstrated a relationship between the extent of right lateralization of body image and bilateral digital skin temperature during a controlled temperature stress test. In addition, subjects showing a reliable right side awareness demonstrated more unilateral vasospastic attacks in their right hand than their left hand white subjects showing no clear right lateralization by body image reported more left hand attacks than right hand attacks. These results were taken as consistent with previous work on the relationship between skin conductance and lateralization of body image. 相似文献
155.
妊娠前不同体重指数与围产结局的关系研究 总被引:2,自引:0,他引:2
目的研究妊娠前不同体重指数对围产结局的影响。方法回顾性分析2005~2007年在我院分娩的单胎妇女238例,按妊娠前体重指数(BMI)分为BMI在19.8~23.9的正常BMI组、BMI 24~27的高BMI组和BMI≥27的肥胖组。新生儿体重≥4000g为巨大儿。比较正常BMI组、高BMI组和肥胖组的围产结局。结果全部资料共有238例,其中正常BMI组182例,高BMI组117例,肥胖组56例,巨大儿的发生率分别为10.4%、19.6%、28.6%,妊娠期高血压病、妊娠期糖尿病、羊水过多的风险随妊娠前BMI增加而上升,早产、剖宫产、新生儿病率的发生率亦随妊娠前BMI增加而升高,差异有显著性。结论妊娠前异常的母亲体重指数高度影响巨大儿的发生率;随妊娠前BMI增加不良围产结局的风险增加。 相似文献
156.
Ch. Ell J. Braun H. J. König S. Domschke W. Domschke 《Journal of molecular medicine (Berlin, Germany)》1985,63(12):572-574
Summary The pharmacokinetics of high-dose metoclopramide (10 mg/kg body wt. in five infusions of 2 mg/kg body wt. each) was studied in 11 patients (5 females, 6 males) in two groups: group A with and group B (consisting of five patients) without forced diuresis. When the drug was infused, forced diuresis had no influence on the pharmacokinetics of metoclopramide (serum level after the 1st infusion was 851±361 ng/ml in group A versus 840±348 ng/ml in group B; after the 5th infusion it was 2,005±588 ng/ml in group A versus 2,463±1,350 ng/ml in group B). There were significant differences in the 24-h serum levels (582±308 ng/ml in group A versus 379±170 ng/ml in group B;P<0.05) and in the elimination half life (8.5±2.6 h in group A versus 6.1±1.1 h in group B;P<0.05). The results demonstrate that the dosage regimen originally suggested by Gralla for cytostatic drugs, with forced diuresis for high-dose metoclopramide therapy, may also be applied, with no dosage reduction, with to other cytostatic drugs which do not require forced diuresis. 相似文献
157.
V. Vihko J. SoimajÄrvi E. Karvinen P. Rahkila M. Havu 《European journal of applied physiology》1978,39(3):209-218
Summary On the basis of maximal oxygen uptake (
O2 max) 18 normal, healthy men were divided into two groups of equal size: moderately trained subjects (MTR) each having
O2 max below 65.0 ml·min–1·kg–1 body weight (54.0±8.3) and well trained subjects (WTR), whose
O2 max exceeded 65.0 ml·min–1·kg–1 body weight (69.2±4.1). The WTR group had slightly (non significant, n.s.) higher percentage of slow twitch, oxidative (SO) fibers in M. vastus lateralis and higher (n.s.) activities of cytochrome c oxidase (CytOx), succinate dehydrogenase (SDH), 3-hydroxyacyl-CoA-dehydrogenase (HADH), and citrate synthase (CS), while lactate dehydrogenase (LDH) activity was lower (n.s.). In the MTR group only, the SO-%, and the activities of CytOx, SDH and HADH correlated positively with
O2 max, and LDH negatively with
O2 max. These correlations were not significant in the WTR group possibly because of the adaptations produced by training in this group. Multiple regression analysis was used to elucidate the best combination of variables to explain the variance in
O2 max. The best model consisted of the sum of relative activities of oxidative muscle enzymes (CytOx, SDH, HADH, CS), muscle LDH activity, body fat content (% F) and lean body mass. This model explained 69% of the variance in
O2 max; and of the individual variables % F was of utmost importance. 相似文献
158.
The effects of ovariectomy and estradiol replacement were determined in streptozotocin-diabetic female rats maintained on daily injections of protamine zinc insulin. Similar changes in food intake and body weight in these animals and in nondiabetic control animals indicate that the effects of estradiol on these measures are probably not dependent on changes in pancreatic insulin secretion. Acute and chronic insulin challenges in ovariectomized rats maintained on estradiol benzoate, nafoxidine or oil were also examined. The effects of insulin were not attenuated by prior estrogen conditioning, and there was no evidence of insulin resistance. These experiments suggest that the effects of estradiol on body weight and food intake in female rats are not dependent upon altered insulin levels nor attenuation of the effects of insulin. Estradiol may exert its influence on eating and body weight via separate and possibly more direct pathways. The data also are consistent with the suggestion that ovariectomy-induced and hypothalamic obesities are separate phenomena. 相似文献
159.
目的:观察低剂量γ射线照射人离体外周血对血清中一氧化氮(NO)和一氧化氮合酶(NOS)水平的影响。方法:采集10份健康献血员全血,肝素抗凝,然后采用γ射线照射,照射剂量率为17Gy/min,总吸收剂量为1Gy,分别于照射前及照射后1h,2h采用分光光度法检测血清中NO含量和NOS活性。结果:经γ射线照射1h后,血清中NO及NOS水平与照射前比较明显升高(P〈0.01);照射后2h,血清中NOS水平与照射后1h比较无统计学差异(P〉0、05),但是还明显高于照射前的水平(P〈0.01);在照射后2h,血清中NO含量与照射后1h比较明显降低(P〈0.01),但仍明显高于照射前水平(P〈0.01)。结论:采用剂量为1Gy的γ射线照射外周血,可引起血清中NO水平及NOS活性的显著升高.从而为低剂量辐照自体血回输对肿瘤的辅助治疗提供了理论支持。 相似文献
160.
Two experiments tested the view that task-induced autonomic-somatic gradient parallelism does exist and that the steeper the physiological gradients, over the course of a task, the more involved the subject and the greater the effort. Thirty-three male subjects performed easy and difficult versions of a continuous reaction time task. In both experiments the difficult task prompted steeper electromyographic (EMG) activity gradients than did the easy version. Scores on heart rate (HR) and skin conductance did not show clear gradients. However, task-dependent effort was positively related to the magnitude of the initial HR acceleration and to the steepness of the EMG gradient. The autonomic-somatic coupling hypothesis of Obrist did not explain the results. Instead, evidence for ventilatory-somatic parallelism was found. 相似文献