高血压病血压昼夜节律与心肌缺血的关系

目的 探讨高血压病患者血压昼夜节律改变与心肌缺血之间的关系及临床意义。方法对90例高血压病患者,根据动态心电图上有无心肌缺血(MI)分为MI组(40例)和无MI组(50例),并与20例健康体检者进行对照,观察3组的动态血压变化,同时分析血压昼夜节律正常组和异常组的心肌缺血的发生情况。结果 高血压病伴有MI的患者中,除dSBP、24hDBPL、dSBPL、dDBPL与无MI组比较无统计学差异外,其余各项动态血压指标均明显高于无MI组(P<0.01);高血压病血压昼夜节律异常组发生MI者明显高于血压昼夜节律正常组(P<0.05)。结论 高血压病患者中伴有血压昼夜节律异常者更易导致心肌缺血的发生。对高血压病患者的治疗,除积极控制血压外,还应注意检测和逆转异常的昼夜血压节律,对减少心肌缺血的发生和靶器官损害具有重要意义。     

Effect Of Pulsatile Electromagnetic Fields On Blood Viscosity And Coagulation

Ithasbeenprovedthatanumberofdiseasesarerelatedwithabnormalityofbloodviscosityandcoagulationinclinicalresearch.Bloodhyperviscosityandhypercoagulationcauseandaccelearatethedevelopmentofcertaindiseases,deathrateofsomeofwhicharerisingwithyears.Lookingforawaytoreducebloodviscosityandrestrainfasterandstrongercoagulationbecomesasubjectdrawingmoreattention.Theproperseofthisresearchwastofindsuchaway.Intheblood,therearechargrdRBC,WBC,PLT,inorganicions,sothattheremustbesensitiveandcomplicatedresponse…     

四种脊椎动物血细胞亚显微结构的比较观察

用透射电镜观察了罗非鱼、虎纹蛙、家鸽和家兔各类血细胞的亚显微结构、结果表明：鱼、蛙。鸽的红细胞呈长椭圆形、长梭形或长橄榄形，有核，核周异染色质明显：而兔的红呈两面凹陷的圆盘状、无核、胞内充满血红蛋白、鱼、蛙、鸽血中尚见到血栓细胞，其形状与红细胞相似，体积较小，胞核较大；兔血小板呈不规则形，无核。鱼、蛙、鸽、兔的白细胞，形状结构基本相似，除能见到核和细胞器之外，胞质内的特殊颗粒以及细胞伸出的伪足、微     

不同造模方法所致“热毒血瘀证”模型家兔血液流变学改变的比较研究

本文通过金葡菌、大肠杆菌内毒素、地塞米松加内毒素等三种不同的攻毒方法复制了“热毒血瘀证”的动物模型。结果提示三种模型在血凝学指标上均表现为KPTT、PT明显缩短,而在血液流变学指标上则有不同。金葡菌所造模型表现为明显的高粘状态,内毒素模型则表现为明显的低粘状态,地塞米松加内毒素模型则改变不明显。     

Transducers for foot pressure measurement: survey of recent developments

Recent advances in the development of transducers for the measurement of vertical and shear forces acting on the plantar surface of the foot are reviewed. Barefoot and in-shoe discrete and matrix transducers are reviewed in terms of structure, operation, performance and limitations. Examples of capacitive, piezoelectric, optical, conductive and resistive types of transducer are presented. Where available, the current clinical status is specified.     

Determination of capillary leakage due to recombinant interleukin-2 by means of noninvasive conductivity measurements

Summary One of the most common side effects of treatment with recombinant interleukin-2 (IL-2) is capillary leakage. Its genesis is not completely understood. The aim of the study was to determine whether capillary leakage can be monitored by means of a non-invasive conductivity technique and to study its starting point. Eight patients with advanced renal cell cancer were studied in a medium care section of the Department of Medical Oncology, University Hospital over 4 days during treatment sessions of continuous, intravenously administered IL-2 (mean dose of 15.6 × 10⁶ IU · m^–2 · day ^–1). The fluid shift from the intravascular to the extra- and intracellular compartments was monitored by means of noninvasive conductivity measurements. Changes in blood volume were calculated from serial erythrocyte counts. The clinical parameters of capillary leakage (oliguria, positive fluid balance, and gain in mass) were recorded. The mean gain in mass was 9% after 4 days of IL-2 treatment. The extracellular fluid volume increased significantly [46 (SD 23.2)%; P < 0.01], whereas the intracellular fluid volume did not change. The increase in blood volume (BV) amounted to 7% (P < 0.05). The decline in albumin concentration was significantly more than the increase in BV [38 (SD 4.3) %; P < 0.01], indicating capillary albumin leakage. The main changes were observed after the 2nd day of treatment. From this study, it is suggested that conductivity measurements are a suitable method to monitor capillary leakage induced by IL-2, and could be used to detect the exact onset and severity of this leakage. The leakage started within the first 24 h of treatment and was detected as a fluid shift from the intravascular to the extracellular space, while the intracellular compartment remained stable. These measurements could be useful during intervention studies with the aim of preventing this adverse effect of IL-2.     

Changes in muscle responses to stimulation of the motor cortex induced by peripheral nerve stimulation in human subjects

The aim of this study was to determine whether prolonged, repetitive mixed nerve stimulation (duty cycle 1 s, 500 ms on-500 ms off, 10 Hz) of the ulnar nerve leads to a change in excitability of primary motor cortex in normal human subjects. Motor-evoked potentials (MEPs) generated in three intrinsic hand muscles [abductor digiti minimi (ADM), first dorsal interosseous (FDI) and abductor pollicis brevis (APB)] by focal transcranial magnetic stimulation were recorded during complete relaxation before and after a period of prolonged repetitive ulnar nerve stimulation at the wrist. Transcranial magnetic stimuli were applied at seven scalp sites separated by 1 cm: the optimal scalp site for eliciting MEPs in the target muscle (FDI), three sites medial to the optimal site and three sites lateral to the optimal stimulation site. The area of the MEPs evoked in the ulnar-(FDI, ADM) but not the median-innervated (APB) muscles was increased after prolonged ulnar nerve stimulation. Centre of gravity measures demonstrated that there was no significant difference in the distribution of cortical excitability after the peripheral stimulation. F-wave responses in the intrinsic hand muscles were not altered after prolonged ulnar nerve stimulation, suggesting that the changes in MEP areas were not the result of stimulus-induced increases in the excitability of spinal motoneurones. Control experiments employing transcranial electric stimulation provided no evidence for a spinal origin for the excitability changes. These results demonstrate that in normal human subjects the excitability of the cortical projection to hand muscles can be altered in a manner determined by the peripheral stimulus applied.     

A pilot study of the effect of mechanical ventilation and heat exchange on house-dust mites and Der p 1 in New Zealand homes

We have examined the effect of reducing relative humidity (RH), with inbuilt mechanical ventilation and heat-exchange (MVHE) units, on house-dust- mite (HDM) counts and allergen levels, in a pilot study of 10 Wellington dwellings. Recent international prevalence studies in adults and children have confirmed a high prevalence of asthma in New Zealand, Sensitivity to HDM is common among the general population, and HDM is the major allergen associated with asthma. Recent studies of allergen levels have confirmed high concentrations of Der p 1 in the domestic environment. While humidity was significantly reduced in those dwellings fitted with ventilation units, no systematic effect on mites or Der p 1 was observed during the study period. When the reductions in humidity were examined in the context of the time spent below the critical equilibrium humidity (CEH), the intervention led to RH values below the CEH for only 39% of the total of 24-h periods for which measurements were made. Reducing RH by means of MVHE in New Zealand domestic dwellings does not lower humidity sufficiently, or long enough, to have any measurable effect on HDM populations.     

125I-白细胞介素-8在小鼠体内的分布研究

为了解白细胞介素 - 8的体内行为 ,用 Bolton- Hunter法对 IL- 8进行 1 2 5I标记 ,并测定它在小鼠体内的分布 ;得到了 1 2 5I- IL- 8在小鼠血、心、肝、肺、肾、骨、脾等脏器中的分布以及它在血液中的快相半排期 T1 /2α为 0 .3 2 h和慢相半排期 T1 /2β为 8.0 1h。1 2 5I- IL- 8主要通过肾排除     

孕妇妊娠晚期和妊高征患者血小板参数的分析

目的观察正常孕妇妊娠晚期和妊高征患者血小板参数的变化及临床意义。方法采用日本Sysmex KX-21型血液细胞分析仪分别对正常孕妇（118例）、妊高征患者（59例）及对照组（正常婚检妇女59例）的血液标本进行血小板（PLT）计数、平均血小板体积（MPV）、血小板分布宽度（PDW）的测定。结果妊高征组和正常孕妇组的MPV、PDW显著高于对照组（P〈0.01）;妊高征组MPV、PDW明显高于正常孕妇组（P〈0.05）;妊高征组的PLT显著低于对照组（P〈0.01）。结论妊高征患者由于血小板消耗和破坏增加,导致血小板减少,MPV、PDW明显增高,因此,检测血小板参数对预测妊高征的发生有一定的参考意义。