尼群地平固体分散体微丸的制备与评价

目的采用小型离心造粒技术制备尼群地平固体分散体微丸。方法以微丸的粉体学性质、收率（Yield）和10min药物累积溶出量（P10）为评价标准,通过处方单因素试验考察可溶性载体、不溶性载体及两者的比例对微丸质量的影响;通过制备工艺单因素试验,考察润湿剂中乙醇的浓度及用量、离心造粒转速及时间对微丸质量的影响;并通过X射线粉末衍射（XRD）和差示扫描量热法（DSC）试验对药物的可能存在状态进行判断。结果尼群地平固体分散体微丸的处方与制备工艺为：可溶性载体采用泊洛沙姆（F68）,不溶性载体采用低取代羟丙基纤维素（L-HPC）,两者的比例为2：7,润湿剂为70%乙醇,用量25ml,离心造粒转速为300r/min,时间30min,所得微丸P10达86%以上。XRD和DSC实验表明,药物以无定形存在于固体分散体中,但在微丸中有少量晶体析出。结论采用上述方法制备的尼群地平固体分散体微丸,具有固体分散体结构和显著的速释特征。     

Evaluation of anti-inflammatory activity of Cissampelos pareira root in rats

In the present study, 50% ethanolic extract of Cissampelos pareira roots (CPE) in acute, subacute and chronic models of inflammation was assessed in rats. Per os (p.o.) administration of CPE (200, 400 mg/kg) exhibited significant anti-inflammatory activity. In acute inflammation as produced by carrageenin 59.55% and 64.04%, by histamine 15.38% and 30.77%, by 5-hydroxytryptamine 17.78% and 31.11% and by prostaglandin E₂-induced hind paw edema 19.23% and 30.77% protection was observed. While in subacute anti-inflammatory models using formaldehyde-induced hind paw edema (after 1.5 h) 38.36% and 47.95% and in chronic anti-inflammatory model using cotton pellet granuloma 15.02% and 19.19% protection from inflammation was observed. CPE did not show any sign of toxicity and mortality up to a dose level of 1000 mg/kg, p.o. in rats. Both acute as well as chronic administration of CPE (100, 200 and 400 mg/kg, p.o.) did not produce any gastric lesion in rats. These data indicate that CPE possesses significant anti-inflammatory activity without ulcerogenic activity suggesting its potential as an anti-inflammatory agent for use in the treatment of various inflammatory diseases.     

胃舒宁颗粒制备及质量控制

胃舒宁颗粒是我院制剂室生产唯一的无糖型颗粒剂，功能镇痛，健胃、制酸。临床上用于治疗胃脘疼痛、胃酸过多、胃及十二指肠溃疡、慢性胃炎、效果显著。笔者建立了其制备工艺及质量控制标准，现报道如下。     

瘀血疏颗粒治疗气滞血瘀证的疗效观察 附90例病例报告

就中药新制剂“瘀血舒”颗粒对气滞血瘀证的临床疗效,与单用西药的对照组进行了对照观察。结果表明:治疗组在总有效率、显效率、改善胁痛、胸闷等症状和促进青紫舌向正常舌转变等方面,其疗效均优于对照组(P〈0.05)。在影响血压、血色素和有关肝、肾功能等指标方面,两组的观察结果之差异并无统计学意义。据此认为:“瘀血舒颗粒”在改善气滞血瘀证的临床症状和舌象方面,疗效确切,且对人体无明显毒副作用,而且服用方便,易于携带和保存,是治疗气滞血瘀证的良好中药新制剂,经过进一步研究,可望成为有良好开发前景的新药。     

青霉素发酵过程菌丝成球的工程特性研究

研究了产黄青霉菌(P.chrysogenum)876菌株发酵过程中菌丝成球现象。菌丝成球后,由于在菌球内外形成一个氧浓度分布梯度,菌丝临界氧由25%提高至40%,从而对反应器供氧提出了更高的要求。一旦反应器供氧不足,菌体碳、氮源代谢能力减弱,不利于青霉素合成。这种代谢与工程因素的交互影响,为发酵过程优化控制提出了一个值得探讨的,既有理论学术价值又有实际意义的研究课题。     

安福拉明治疗单纯性肥胖30例临床观察

42例单纯性肥胖患者随机分成两组,治疗组30例,服用安福拉明;对照组12例,服用七消丸,疗程为两个月。结果表明:治疗组体重平均下降7.32kg,并有不同程度的降血压、降血脂、降血糖作用。对照组体重平均下降2.54kg。两者有显著差异(P<0.01)。安福垃明疗效确切,对心、肝、肾等各脏器无损害,副作用小,是现阶段理想的减肥药物。     

Accidental lodgment of an air gun pellet in the maxillary sinus of a 6-year old girl: a case report

Abstract  – Air gun, although considered a toy, can cause injuries ranging from trivial to very grievous. The type and severity of injuries depend on the type of air gun used, the distance at which it is fired, and the anatomic site at which the pellet hits. An interesting case involving a young girl, who was accidentally hit by an air gun pellet at a village fair, is described. The pellet penetrated the maxillary bone to be lodged in the sinus. The treatment strategy along with literature review on short- and long-term complications of air gun injuries is presented.     

Clinical and neuroradiological correlations in a patient with a wandering retained air gun pellet in the brain

The authors present the case of a patient with an air gun pellet wandered from ventricular system in the subarachnoid space of C2–C3, where it was removed successfully by an interlaminotomy.     

心痛舒片治疗冠心病心绞痛30例疗效观察

目的：观察心痛舒片对冠心病心绞痛的临床疗效，并探讨其作用机制。方法：冠心病心绞痛患者60例，随机分为两组，治疗组30例，口服心痛舒片治疗，对照组30例，口服用丹参滴丸治疗。结果：治疗组改善临床症状总有效率为86.7％，对照组为63．3％（p〈0.05）。心电图改善的总有效率治疗组为80．0％，而对照组为53．3％（P〈0.05）。结论：心痛舒片治疗冠心病心绞痛有较好的疗效。     

尼群地平固体分散体微丸稳定性的初步研究

目的考察尼群地平固体分散体微丸的稳定性。方法通过影响因素试验和加速试验,考察尼群地平固体分散体微丸的外观,药物和有关物质的含量,以及药物溶出速度（T80）的变化。结果该固体分散体微丸对温度和湿度稳定,对光不稳定,模拟上市包装后稳定性良好。结论尼群地平固体分散体微丸经包装后稳定性较好。