全文获取类型
收费全文 | 6951篇 |
免费 | 421篇 |
国内免费 | 266篇 |
专业分类
耳鼻咽喉 | 178篇 |
儿科学 | 116篇 |
妇产科学 | 55篇 |
基础医学 | 479篇 |
口腔科学 | 94篇 |
临床医学 | 787篇 |
内科学 | 758篇 |
皮肤病学 | 21篇 |
神经病学 | 305篇 |
特种医学 | 411篇 |
外国民族医学 | 5篇 |
外科学 | 2120篇 |
综合类 | 1128篇 |
预防医学 | 161篇 |
眼科学 | 91篇 |
药学 | 396篇 |
14篇 | |
中国医学 | 137篇 |
肿瘤学 | 382篇 |
出版年
2024年 | 16篇 |
2023年 | 134篇 |
2022年 | 273篇 |
2021年 | 333篇 |
2020年 | 241篇 |
2019年 | 219篇 |
2018年 | 240篇 |
2017年 | 228篇 |
2016年 | 239篇 |
2015年 | 232篇 |
2014年 | 475篇 |
2013年 | 460篇 |
2012年 | 334篇 |
2011年 | 453篇 |
2010年 | 313篇 |
2009年 | 339篇 |
2008年 | 323篇 |
2007年 | 345篇 |
2006年 | 296篇 |
2005年 | 283篇 |
2004年 | 231篇 |
2003年 | 185篇 |
2002年 | 161篇 |
2001年 | 158篇 |
2000年 | 125篇 |
1999年 | 112篇 |
1998年 | 104篇 |
1997年 | 93篇 |
1996年 | 80篇 |
1995年 | 78篇 |
1994年 | 46篇 |
1993年 | 48篇 |
1992年 | 39篇 |
1991年 | 32篇 |
1990年 | 30篇 |
1989年 | 34篇 |
1988年 | 30篇 |
1987年 | 33篇 |
1986年 | 33篇 |
1985年 | 26篇 |
1984年 | 27篇 |
1983年 | 16篇 |
1982年 | 31篇 |
1981年 | 16篇 |
1980年 | 17篇 |
1979年 | 16篇 |
1978年 | 8篇 |
1977年 | 14篇 |
1976年 | 9篇 |
1974年 | 8篇 |
排序方式: 共有7638条查询结果,搜索用时 15 毫秒
11.
Summary— KR31080 (2-butyl-5-methyl-6-(1-oxopyridin-2-yl)-3-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-3H-imidazo[4,5-b] pyridine) is a potent inhibitor of angiotensin type 1 (AT1 ) receptors in rabbit aorta and human recombinant AT1 receptors. In the isolated rabbit thoracic aorta, KR31080 caused a nonparallel shift to the right of the concentration-response curves to angiotensin II (All) with decreased maximal response (pD'2 = 10.1 ± 0.1), but had no effect on the contractile response induced by norepinephrine. KR31080 inhibited specific [125 I]AII binding to rabbit aortic membranes (AT, receptors) and [125 I][Sar1 , Ile8 ]AII binding to human recombinant AT1 receptors in a concentration-dependent manner with IC50 values of 0.84 ± 0.08 nM and 1.92 ± 0.15 nM, respectively, but did not inhibit specific [125 I)AII binding to bovine cerebellum membranes (ÀT2 receptors). In the Scatchard analysis, KR31080 interacted with rabbit aortic AT1 receptors in a competitive manner, similar to losartan. These results demonstrate that KR31080 is a potent and AT1 selective angiotensin receptor antagonist which exerts a competitive antagonism in the [125 I]AII binding assay and insurmountable AT1 receptor antagonism in the functional study. 相似文献
12.
[目的]揭示青少年胸椎特发性侧凸患者椎管内脊髓的偏移,明确其变化趋势,并探讨其可能的发生机制和临床意义。[方法]本研究包括39名以右胸弯为主弯的青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)患者。测量主胸弯节段内(T5-12)椎管内脊髓与凸凹侧椎弓根之间的距离,计算脊髓的偏移,揭示其变化趋势,并分析顶椎区脊髓偏移与主胸弯Cobb's角和顶椎相对偏移之间的相关性。[结果]在T5-12节段椎管内,脊髓与凸侧椎弓根之间的距离显著大于与凹侧椎弓根之间的距离(P〈0.05),即脊髓向凹侧椎弓根偏移,且以顶椎区最为显著,而逐渐向两侧端椎区递减。顶椎区脊髓偏移与主胸弯Cobb’s角和顶椎相对偏移存在显著的正相关(相关系数分别为0.631和0.546)。[结论]胸椎特发性脊柱侧凸患者存在侧凸节段椎管内脊髓偏移的现象,且以顶椎区最显著。研究结果提示脊髓偏移可能与脊椎偏移后凹侧脊神经的牵拉有关,而且凹侧置钉的风险高于凸侧。 相似文献
13.
目的 总结 17例胸椎骨折患者的特点与诊疗情况 ,为提高此类合并胸外伤患者的疗效提供有效的治疗方案。方法 分析了 17例胸椎骨折患者的临床特点、诊疗经过、近远期随访结果。结果 14例 (82 .4 % )合并肋骨骨折 ,11例 (6 4 .7% )合并血气胸 ,10例 (5 8.8% )合并严重脊髓伤 ,3例 (30 % )远期脊髓伤为有用恢复。结论 胸椎骨折常合并肋骨骨折、血气胸、严重脊髓损伤 ,预后较差 ,为此应重视合并胸外伤的胸椎骨折的围手术期处理 相似文献
14.
Takashi Iwazawa Mitsunobu Imazato Tadashi Ohnishi Yutaka Kimura Hiroshi Yano Takushi Monden 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(8):386-389
We report adult congenital bronchoesophageal fistula with both symptomatic fistula and asymptomatic one. A 56-year-old woman
with a history of cough after drinking fluids was diagnosed as bronchoesophageal fistula by upper gastrointestinal series
that showed a diverticulum in the middle portion of the esophagus with a fistula between the esophagus and right lower lung.
Esophagoscopy revealed an orifice of the fistula located 27 cm from the incisors. Computed tomography showed chronic inflammatory
change with bronchiectasis in the S6 segment of the right lung. The patient underwent video assisted thoracic surgery that
identified two fistulae without missing a symptomatic one, and both were successfully resected. The fistulae were lined by
squamous epithelium and smooth muscle without evidence of malignancy, infection or chronic inflammation that were histologically
compatible with congenital fistulae. 相似文献
15.
16.
目的研究两种不同脊柱后路减压方法治疗胸腰段骨折脱位合并脊髓损伤的手术治疗效果。方法回顾分析本院1996年3月~2002年6月收治的胸腰段骨折脱位并脊髓损伤患者76例,按不同减压方法将其分为两组:切除一侧或两侧椎板、椎弓根或部分关节突行侧前方环状减压AF内固定者40例,为直接减压组;体位复位结合AF器械矫正复位36例,为间接减压组。统计学分析,两组资料具有可比性。对术后神经功能恢复情况,按ASIA神经功能评定标准进行评定。中晚期并发症,根据是否有腰背痛,下肢根性痛、麻木无力,两便功能障碍进行评定。生活能力按FIM评定。结果两组病例获6个月~5年随访,结果表明,术前脊髓完全性损伤,术后均无恢复;术前脊髓不完全性损伤,术后两组间比较差异无显著性。中晚期并发症发生,直接减压组高于间接减压组;术后生活自理能力,间接减压组好于直接减压组。结论间接减压手术方法治疗胸腰段骨折脱位合并脊髓损伤不失为一种早期治疗的首选方法。 相似文献
17.
Pratipal Singh Vivek Vijjan Manu Gupta Deepak Dubey Aneesh Srivastava 《International journal of urology》2007,14(6):558-560
Congenital thoracic ectopic kidney is a very rare developmental anomaly and the rarest form of all ectopic kidneys. It is usually asymptomatic and discovered incidentally on routine chest radiography. Herein we reported the first case of staghorn stone in a thoracic kidney managed successfully by percutaneous nephrolithotomy. 相似文献
18.
19.
P. D. Tsitsopoulos C. A. Tsonidis K. A. Nanasis K. D. Tsoleka G. N. Tavridis 《Acta neurochirurgica》1995,135(3-4):198-200
Summary This report deals with a case of rhabdomyosarcoma in the upper thoracic spine. It is of particular interest, not only for the rarity of type and location of this tumour, but for its clinical course, which presented fluctuations of neurological status, included an acute demonstration of complete paraplegia followed by full recovery after conservative treatment, and gradual relapsing of neurological deficit, one year later. 相似文献
20.
Diagnosis and treatment of thoracic outlet syndrome 总被引:2,自引:0,他引:2
Masataka Abe Tadashi Shimamura Jun Nishida Katsuaki Ichinohe 《Journal of orthopaedic science》1997,2(2):119-127
Patients who develop symptoms of thoracic outlet syndrome (TOS) have a predisposing anatomic abnormality. In most patients
with TOS, the symptoms are caused by entrapment of the brachial plexus and they do not arise from compression of the subclavian
artery, as was previously thought. The tests advocated for diagnosing this common syndrome (i.e., evaluating the positional
compression of the artery when the arms are raised, the neck is turned, or the shoulders are braced) cannot accurately diagnose
this syndrome. There are two reasons for this. The symptoms of TOS are not related to the compression of the artery in the
outlet in 98% of patients, and 75% of normal individuals without symptoms show diminished radial pulse on various provocation
tests. We employed four timed provocation tests (minute tests) to diagnose TOS: the timed Morley test, timed Wright test,
timed Eden test, and elevated arm stress exercise, all of which are very sensitive. In normal individuals without symptoms,
20% experience transitional symptoms such as slight pain and tiredness, on these tests indicating a subclinical state. TOS
is treated by keeping the thoracic outlet wide, this being done either conservatively or surgically. In 1993 and 1994, we
conservatively treated 418 of 422 patients with TOS by means of active exercise, a brace, and by block therapy. These measures
did not reduce the symptoms in 23 of these patients, so surgical treatment was indicated. In the remaining 4 of the 422 patients,
conservative treatment was not indicated and surgery was performed directly. All the patients showed significant clinical
improvement of varying degree.
Presented at the 69th Annual Meeting of the Japanese Orthopaedic Association, Tokyo, April 12, 1996 相似文献