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101.
L. Marzio F. Di Felice V. Celiberti O. Pieramico L. Grossi M. DiGioacchino B. P. Imbimbo F. Cuccurullo 《European journal of clinical pharmacology》1990,39(4):369-372
Summary To evaluate the influence of the stomach and the cholinergic system on gallbladder contraction induced by physiological stimuli, the reduction in gallbladder volume in 7 healthy volunteers has been studied by real-time ultrasonography after the oral and intraduodenal administration of olive oil, preceded by pretreatment with cimetropium bromide or placebo. After an overnight fast, each subject swallowed 50 ml olive oil or it was administered through a naso-duodenal tube in the proximal duodenum. Cimetropium bromide 5 mg or placebo was given intravenously under double-blind control.After the placebo pretreatment, gallbladder contraction was greater and faster after intraduodenal oil than after oral oil. Cimetropium bromide decreased the extent, velocity and duration of gallbladder contraction induced by intraduodenal olive oil but it only reduced the velocity of the contraction induced by oil given orally.It is concluded that in normal human subjects the stomach modulates the extent and velocity of postprandial gallbladder contraction and that anticholinergic agents antagonize the gastric and duodenal phases of the response of the gallbladder to a meal. 相似文献
102.
取代四氢异喹啉衍生物的合成及其生物活性 总被引:7,自引:0,他引:7
粉防己碱有钙拮抗作用,临床试用于治疗高血压,其裂解产物钙拮抗作用降低,但有α-肾上腺素能受体拮抗作用,本文以裂解物为先导化合物设计合成了两类取代的四氢异喹啉衍生物Ⅲ及Ⅳ。初步药理试验表明:大部分化合物有α-肾上腺素能受体拮抗作用,少数化合物钙拮抗活性有所增强,其中Ⅲ15,19对正常麻醉大鼠有一定的降压作用、Ⅳ17,19对实验性动物心律失常有明显的保护作用。部分化合物量化计算表明:化合物与α1-受体作用方式可能是形成电荷转移复合物。 相似文献
103.
选用昆明种小鼠60只,体重18~24克,随机分成三组,每组20只,雌雄各半。通过饮水染毒。一组正常对照,饮自来水,二组饮30ppm含镉水,三组饮300ppm含镉水,染毒时间三个半月。观察指标:体重增长速度、脏器系数、肝肾中镉含量、重点病理形态学改变(光镜和电镜)。结果,30ppm组小鼠肝肾组织有一定病变,300ppm组小鼠的光镜和电镜的病理形态学改变更为明显。提示,小鼠长期摄入镉可引起一定的损害。 相似文献
104.
本文研究了蛛网膜下腔注射神经降压素(neurotensin,NT)对大鼠血压和心率的影响,结果表明:注射NT后血压立即下降,继而有所回升,但不及正常水平,然后再次降低,持续60min;心率无明显改变。H1受体阻断剂苯海拉明能部分阻断NT的降血压效应,H2受体阻断剂甲氰咪胍无翻转作用。注射组胺释放剂Compound48/80使血压下降,待血压恢复正常水平后,再注射NT,其降压效应减弱。结果提示:蛛网 相似文献
105.
腧穴针感在针刺防治疾病过程中发挥着重要作用。本文从针刺作用的感受器,腧穴针感的外周传入神经,以及针感与中枢神经的关系,诸方面,列举大量实验结果和理论,阐明针感形成的物质基础是神经系统。 相似文献
106.
H. J. SPARR C. LEO E. LADNER E. DEUSCH H. BAUMGARTNER 《Acta anaesthesiologica Scandinavica》1997,41(10):1300-1307
Background : The study aimed to assess the relative influence of anaesthesia and muscle relaxation on intubating conditions and the haemodynamic and catecholamine responses to tracheal intubation.
Methods : Sixty ASA 1 or 2 patients were randomly assigned to one of four groups (15 patients each) that differed in the depth of anaesthesia (thiopentone plus fentanyl 2.5 μg kg-1 or thiopentone alone) and the degree of vecuronium–induced neuromuscular block (100% or _>: 65%) at intubation. Muscle relaxation was measured at 0.1 Hz by means of mechanomyography. Heart rate (HR) and mean arterial blood pressure (MAP) were measured before and after induction of anaesthesia, and 1 min and 5 min following intubation, while adrenaline (A) and noradrenaline concentrations (NA) were determined from arterial blood samples.
Results : Intubating conditions were improved primarily by providing complete muscle relaxation at the adductor pollicis muscle (P<0.001) and to a lesser extent by adding fentanyl to thiopentone (P=0.04). The response of HR and MAP to tracheal intubation was attenuated mainly by fentanyl (P<0.001). Complete muscle relaxation further diminished the response of MAP to intubation (P=0.03). Changes in A and NA were dependent on the depth of anaesthesia only (P =>0.01).
Conclusion : The results of the study demonstrate that the sympathoadrenal response to intubation is attenuated by adding fentanyl (2.5 kg-1 ) to an induction regimen with thiopentone, whereas provision of complete muscle relaxation at the adductor pollicis muscle is necessary to attain smooth intubating conditions. 相似文献
Methods : Sixty ASA 1 or 2 patients were randomly assigned to one of four groups (15 patients each) that differed in the depth of anaesthesia (thiopentone plus fentanyl 2.5 μg kg
Results : Intubating conditions were improved primarily by providing complete muscle relaxation at the adductor pollicis muscle (P<0.001) and to a lesser extent by adding fentanyl to thiopentone (P=0.04). The response of HR and MAP to tracheal intubation was attenuated mainly by fentanyl (P<0.001). Complete muscle relaxation further diminished the response of MAP to intubation (P=0.03). Changes in A and NA were dependent on the depth of anaesthesia only (P =>0.01).
Conclusion : The results of the study demonstrate that the sympathoadrenal response to intubation is attenuated by adding fentanyl (2.5 kg
107.
108.
膳食结构的变化对脂肪肝患者疗效观察 总被引:4,自引:0,他引:4
目的 通过营养干预改变脂肪肝患的膳食结构和生活方式,并观察其疗效。方法 营养干预措施采用询问法登记摄入食物的种类和数量,制订膳食原则及编制食谱。健康教育进行营养知识讲座及咨询活动。结果 通过营养干预脂肪肝患改变了原有的膳食结构及饮食习惯,能量摄入和消耗处于动态平衡;增加粗粮、蔬菜和鱼禽类等食品的摄入量,动物性脂肪摄入减少;53.1%脂肪肝患有好转,46.2%超重或肥胖的人体重恢复到标准体重范围内。结论 普及营养知识,养成良好的饮食和生活习惯,防止食源性疾病的发生。 相似文献
109.
用PowerPoint XP设计幻灯片元素动画效果的实践 总被引:6,自引:1,他引:5
PowerPoint XP新特性中突出的就是其动画设计功能的加强。文中对新增加的与动画没计相关的功能使用要点结合实际作了较详细的叙述。 相似文献
110.
Edward A. Essock William K. Krebs James R. Prather 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1992,91(3):520-524
Summary The ability of humans to detect striated stimuli on the distal phalanges was found to be highly anisotropic. Observers were much more sensitive to stripes presented in the proximal-distal orientation than to stripes in any other orientation. This tactile anisotropy was contrasted with the well-known visual anisotropy in which sensitivity is greatest for stripes at the horizontal and vertical orientations. We suggest that both the tactile anisotropy and the visual anisotropy are caused by corresponding anisotropies in the distribution of preferred orientations of orientation-selective neurons with in the respective modalities. 相似文献