全文获取类型
收费全文 | 831篇 |
免费 | 14篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 8篇 |
妇产科学 | 4篇 |
基础医学 | 7篇 |
口腔科学 | 11篇 |
临床医学 | 106篇 |
内科学 | 24篇 |
皮肤病学 | 1篇 |
神经病学 | 17篇 |
特种医学 | 5篇 |
外科学 | 478篇 |
综合类 | 42篇 |
预防医学 | 11篇 |
药学 | 110篇 |
中国医学 | 9篇 |
肿瘤学 | 13篇 |
出版年
2023年 | 4篇 |
2022年 | 12篇 |
2021年 | 22篇 |
2020年 | 14篇 |
2019年 | 16篇 |
2018年 | 23篇 |
2017年 | 13篇 |
2016年 | 16篇 |
2015年 | 3篇 |
2014年 | 27篇 |
2013年 | 50篇 |
2012年 | 12篇 |
2011年 | 28篇 |
2010年 | 19篇 |
2009年 | 23篇 |
2008年 | 15篇 |
2007年 | 16篇 |
2006年 | 17篇 |
2005年 | 7篇 |
2004年 | 17篇 |
2003年 | 6篇 |
2002年 | 15篇 |
2001年 | 17篇 |
2000年 | 13篇 |
1999年 | 18篇 |
1998年 | 16篇 |
1997年 | 29篇 |
1996年 | 43篇 |
1995年 | 21篇 |
1994年 | 19篇 |
1993年 | 29篇 |
1992年 | 32篇 |
1991年 | 35篇 |
1990年 | 18篇 |
1989年 | 16篇 |
1988年 | 25篇 |
1987年 | 28篇 |
1986年 | 17篇 |
1985年 | 22篇 |
1984年 | 21篇 |
1983年 | 15篇 |
1982年 | 6篇 |
1981年 | 8篇 |
1980年 | 11篇 |
1978年 | 2篇 |
1975年 | 2篇 |
1974年 | 5篇 |
1973年 | 2篇 |
1970年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有850条查询结果,搜索用时 109 毫秒
51.
P. Annila L. Lindgren P. Loula P. Dunkel I. Annila A. Yli-Hankala 《Acta anaesthesiologica Scandinavica》1995,39(3):401-405
The T-wave amplitude of ECG is thought to reflect the sympathetic tone of the heart but anaesthesia studies on this topic are rare. Haemodynamic and ECG T-wave amplitude changes were studied during induction of anaesthesia in 24 ASA I-II patients. Twelve patients were given alfentanil 30 μg kg-1 at induction while physiologic saline was given to the rest (control). Thiopentone was then administered at the rate of 5 mg s-1 until eyelash reflex disappeared. Vecuronium 0.1 mg kg-1 was given thereafter. No anticholinergics were used. The lungs were ventilated with 40% oxygen in air. Haemodynamic parametres and T-wave amplitude were measured before induction, before intubation, 30 s, 3 min and 5 min after intubation. A significandy higher amount of thiopentone was needed to abolish the eyelash reflex in the control group than in the alfentanil group ( P <0.001). There were no changes in heart rate (HR) in the alfentanil group during the trial. Systolic and diastolic arterial pressures (SAP and DAP) were continuously below the preinduction levels in the alfentanil group. After baseline HR, SAP and DAP were significantly higher in the control group than in the alfentanil group at each data point. T-wave amplitude flattened significantly ( P <0.001) after intubation in the control group while no significant changes were seen in the alfentanil group. T-wave flattening correlated to the increases in HR ( P <0.01) and SAP ( P <0.01). Three control patients with flattened T-wave had a transient bigeminia period after intubation. It is concluded that ECG T-wave amplitude flattening was associated with pressure and heart rate response to laryngoscopy and intubation. Alfentanil blunted these responses and prevented T-wave changes after intubation. 相似文献
52.
N. H. KAY M. C. ALLEN R. E. S. BULLINGHAM D. BALDWIN R. J. McQUAY H. A. MOORE R. K. PRICE J. W. SEAR 《Anaesthesia》1985,40(3):223-228
Opioid drugs in high doses can obtund the stress response to major surgery but only at the expense of marked cardiorespiratory depression. The postoperative hormonal response to surgical stress was measured in 20 patients undergoing hysterectomy who were given either meptazinol 100 mg or morphine 15 mg intramuscularly at the end of the surgery. Both drugs at the doses used failed to diminish the stress response. Those patients who received meptazinol showed elevated prolactin levels: this may be an indicator of agonist activity at the mu 1 opioid receptor. 相似文献
53.
Epidural buprenorphine for pain relief after major abdominal surgery. A controlled comparison with epidural morphine 总被引:2,自引:0,他引:2
In a controlled trial epidural buprenorphine was compared with epidural morphine as the sole means of analgesia after major abdominal surgery. Bolus injections of buprenorphine 60 micrograms in 10 ml or morphine 2 mg in 10 ml of normal saline were given on demand for the first 48 hours postoperatively. Both drugs produced significant reduction in pain scores as assessed by the linear visual analogue scale and both produced prolonged analgesia at this dosage, which could be extended by further 'top-ups'. The authors conclude that, for postoperative epidural analgesia, buprenorphine may be the opiate of choice and the reasons for this are discussed. 相似文献
54.
Assessment of tracheal intubation in children after induction with propofol and different doses of remifentanil 总被引:7,自引:0,他引:7
Tracheal intubating conditions were assessed in 112 children after induction of anaesthesia with propofol and remifentanil 1.0, 2.0 or 3.0 micro g.kg-1. Subjects in a control group were given propofol and mivacurium 0.2 mg.kg-1. Haemodynamic and respiratory parameters were recorded. Plasma catecholamine levels were measured in a subgroup of 40 children. Intubating conditions were acceptable in 14/28 (50%), 18/26 (69%) and 22/27 (82%) in those subjects given remifentanil 1.0, 2.0 or 3.0 micro g.kg-1, respectively, and in 27/28 (96%) of the control group. Intubating conditions in subjects given remifentanil 3.0 micro g.kg-1 were better than in those given remifentanil 1.0 micro g.kg-1 (p < 0.05). There were no significant differences in intubating conditions between those given remifentanil 3.0 micro g.kg-1 and the control group. Systolic blood pressure and heart rate increased in response to tracheal intubation in subjects given remifentanil 1.0 micro g.kg-1 and in the control group (p < 0.05). Time to resumption of spontaneous respiration was prolonged in subjects given remifentanil 3.0 micro g.kg-1 (p < 0.001). In conclusion, remifentanil 2 micro g.kg-1 provides acceptable intubating conditions and haemodynamic stability without prolonging the return of spontaneous respiration. 相似文献
55.
This study investigated whether intrathecal diamorphine affects gastric emptying following elective Caesarean section. Forty women were randomly allocated to receive either diamorphine 300 microg or 0.9% saline as part of a standard spinal anaesthetic. Gastric emptying was measured in the immediate postoperative period using paracetamol absorption. Paracetamol concentrations were measured by enzymatic assay method using a Beckman CX-7 automated analyser. The time to maximum concentration (Tmax) was statistically longer in the diamorphine group (control 41.8, SD 20.8 min; diamorphine 72.6 SD 41.9 min; p < 0.01). During the 2-h study period, mean morphine consumption via a patient controlled analgesia device was significantly higher in the control group (control 9.3, SD 3.6 mg; diamorphine 2.1, SD 2.1 mg; p < 0.01). We conclude that intrathecal diamorphine may contribute to the delay in gastric emptying that occurs immediately following elective spinal Caesarean section. 相似文献
56.
57.
We studied the intubating conditions, haemodynamic and endocrine changes following tracheal intubation during sevoflurane anaesthesia guided by Bispectral Index (BIS) monitoring in 40 children who received either remifentanil 1 microg.kg-1 (group R) or saline 1 ml.kg-1 (group S). Acceptable intubating conditions were found in all patients in group R (n = 20), compared to only 12 patients in group S (p = 0.002). There were no intergroup differences in heart rate, systolic blood pressure and plasma concentrations of epinephrine and norepinephrine at any time point and changes in haemodynamic variables throughout the study period were moderate. Titration of sevoflurane delivery to a target BIS of 35 +/- 5 led to almost equal end-tidal sevoflurane concentrations in either group and remifentanil did not affect the BIS. There were no side-effects in either group that required intervention. Intubating conditions during sevoflurane anaesthesia in children were found to be improved by a single bolus dose of remifentanil 1 microg.kg-1. 相似文献
58.
芬太尼透皮贴剂治疗1 664例老年癌痛的临床疗效分析 总被引:2,自引:0,他引:2
目的探讨老年癌症疼痛病人接受芬太尼透皮贴剂治疗的止痛疗效及安全性.方法全国23个省自治区、直辖市136家医院共1 664例,年龄≥65岁的老年癌痛病人接受了芬太尼透皮贴剂的止痛治疗,平均年龄72.6岁(65~90岁).芬太尼透皮贴剂的初始、15 d和30 d用药剂量均值分别为 31.34 μg/h,40.59 μg/h和47.50 μg/h (25~200 μg/h).结果治疗前疼痛程度评分为7.34.治疗1 d、3 d、6 d、9 d、15 d、30 d疼痛程度评分均值分别降低至3.82,2.80,2.43,2.11,1.83,1.79 (P<0.01),总有效率97.18%.治疗前25.4%的病人生活质量良好,治疗后15 d和30 d,71.15%和73.04%病人生活质量良好(P<0.01).不良反应便秘为10.70%,恶心为11.96%,头晕为6.85%,呕吐为3.85%,嗜睡为2.40%,呼吸抑制为0.12%.86.2%病人选择继续用芬太尼透皮贴剂.结论芬太尼透皮贴剂治疗老年癌痛病人安全有效,病人满意度高.推荐老年病人的初始剂量为25 μg/h. 相似文献
59.
Children frequently received no treatment, or inadequate treatment, for pain and for painful procedures. The newborn and critically
ill children are especially vulnerable to no treatment or under-treatment. Nerve pathways essential for the transmission and
perception of pain are present and functioning by 24 weeks of gestation. The failure to provide analgesia for pain results
in rewiring the nerve pathways responsible for pain transmission in the dorsal horn of the spinal cord and results in increased
pain perception for future painful results. Many children would withdraw or deny their pain in an attempt to avoid yet another
terrifying and painful experiences, such as the intramuscular injections. Societal fears of opioid addiction and lack of advocacy
are also causal factors in the under-treatment of pediatric pain. False beliefs about addictions and proper use of acetaminophen
and other analgesics resulted in the failure to provide analgesia to children. All children even the newborn and critically
ill require analgesia for pain and painful procedures. Unbelieved pain interferes with sleep, leads to fatigue and a sense
of helplessness, and may result in increased morbidity or mortality. 相似文献
60.