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71.
《International journal of hygiene and environmental health》2014,217(2-3):323-327
Exposure to cadmium is known to be associated with reducing nitric oxide (NO) production in experimental conditions, but few studies have examined the association between environmental cadmium exposures and exhaled NO in human. We examined the association between blood cadmium levels and exhaled NO levels in a representative sample of US adults. This investigation was a cross-sectional study of 7813 adults (≥20 years) who participated in the 2007–2008 and 2009–2010 National Health and Nutrition Examination Survey and had their exhaled NO and blood cadmium measurements recorded. The geometric means of the exhaled NO and blood cadmium levels were 13.3 ppb (95% CI: 12.7, 13.9) and 0.51 μg/dL (95% CI: 0.48, 0.54), respectively. Higher blood cadmium levels were associated with decreased exhaled NO levels after adjusting for potential confounding variables. Additionally, a two-fold increase in the blood cadmium levels was associated with a 5% decrease in the exhaled NO levels. The results were significant regardless of the subjects’ smoking status or serum cotinine levels, although the percent changes in the exhaled NO levels differed depending on the extent of smoking.Our findings suggest that blood cadmium levels may be associated with reduced levels of exhaled NO in a general sample of US adults. Moreover, cadmium may partially mediate the effect of smoking on exhaled NO production. 相似文献
72.
目的观察一次性病毒/细菌过滤器在气管插管全麻术中预防气道感染的应用价值,为临床预防策略的制定提供参考。方法选择2011年3月-2013年3月接受气管插管全麻手术的患者76例,按照随机数字表法将其分为观察组和对照组各38例;观察组应用一次性病毒/细菌过滤器,而对照组则未用,分别在麻醉前和手术结束时用无菌棉签采集麻醉机呼气端、吸气端表面标本行细菌学检测;在手术结束时收集钠石灰罐底部10g钠石灰行细菌学检测,对比两组患者的检测结果和术后24h内气道感染发生率。结果两组患者在麻醉开始前麻醉机呼气端、吸气端细菌学培养结果均为阴性;手术结束时,麻醉机吸气端、呼气端和钠石灰的细菌学培养阳性率均为0,对照组分别为5.26%、42.11%和15.79%,观察组细菌培养阳性率均显著低于对照组,差异有统计学意义(P<0.05);术后24h内气道感染发生率观察组为2.63%,显著低于对照组的18.62%,差异有统计学意义(P<0.05)。结论麻醉机气管插管全麻可增加患者气道感染的机会,通过一次性病毒/细菌过滤器、及时更换钠石灰等措施,可有效预防气道感染的发生。 相似文献
73.
Anindita Dutta Sanghita Roychoudhury Saswati Chowdhury Manas Ranjan Ray 《International journal of hygiene and environmental health》2013,216(3):301-308
To perform sputum analysis for verification of pulmonary changes in premenopausal rural Indian women chronically exposed to biomass smoke during cooking.Three consecutive morning sputum samples were collected from 196 women (median age 34 years) cooking with biomass and 149 age-matched control women cooking with cleaner fuel liquefied petroleum gas. Smears made on slides were stained with Papanicolaou and Perl's Prussian blue. Airway oxidative stress was estimated as reactive oxygen species (ROS) generation (by flow cytometry) and superoxide dismutase (SOD) level (by spectrophotometry) in sputum cells. Airway inflammation was measured as sputum levels of interleukin (IL)-6, -8 and tumor necrosis factor- alpha (TNF-α). Particulate matter of diameter less than 10 (PM10) was measured using laser photometer while benzene exposure was monitored by measuring trans, trans-muconic acid (t,t-MA) in urine by HPLC-UV. Compared with control, sputum of biomass users contained more neutrophils, lymphocytes, eosinophils, alveolar macrophages, and showed presence of ciliocytophthoria, Charcot-Leyden crystals, Curschmann's spiral. ROS generation was increased by 2-fold while SOD was depleted by 31% in biomass users. They also had higher sputum levels of IL-6, -8 and TNF-α. Levels of PM10 and t,t-MA were 2.9- and 5.8-times higher in biomass-using women. PM10 and t,t-MA levels were positively associated with cellular changes in the sputum, markers of airway inflammation, and oxidative stress. Cooking with biomass alters sputum cytology, and increases airway inflammation and oxidative stress that might result in further amplification of the tissue damaging cascade in women chronically exposed to biomass smoke. 相似文献
74.
Dawn Sheppard 《Veterinary Nursing Journal》2018,33(9):262-265
This article reviews alternatives to endotracheal tubes for airway management in veterinary patients under anaesthesia. Anaesthesia has had many improvements over the past few decades and now airway management is finally catching up and so veterinary anaesthetists have a wider choice of options. As in other areas of anaesthesia, airway management should not be a one-size-fits-all approach. Patient and procedure should be considered before selecting the most appropriate airway device. 相似文献
75.
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77.
含SAM尖端结构域的E26转化特异性因子(SPDEF)是ETS转录因子家族的最新成员之一, SPDEF又称为前列腺源性ETS因子(PDEF),首次发现其在前列腺癌中高度表达,参与肿瘤细胞的增殖分化、迁移凋亡和血管形成。近年来研究发现SPDEF与杯状细胞增生和分化密切相关,是调控呼吸道黏液高分泌的核心因子。对SPDEF调控黏液高分泌的机制及其在呼吸道慢性炎性疾病中的研究进展做一综述,以期为呼吸道黏液高分泌疾病的发病机制和诊治提供新思路。 相似文献
78.
<正>甲型H1N1流感是由甲型H1N1流感病毒感染引起的急性呼吸系统传染病。少数病例病情进展迅速,出现呼吸衰竭、多脏器功能不全或衰竭。这些病人除需一般抗病毒治疗外,常需要机械通气治疗。 相似文献
79.
Chairs Louis-Philippe Boulet Qutayba Hamid Co-authors of sections of the document Simon L Bacon C��line Bergeron Louis-Philippe Boulet Yue Chen Anne E Dixon Pierre Ernst Qutayba Hamid Fernando Holguin Charles G Irvin R John Kimoff Sushma Komakula Catherine Laprise Kim L Lavoie Stephanie A Shore Mihaela Teodorescu Marie-Claude Vohl 《Canadian respiratory journal》2007,14(4):201-208
Asthma and obesity are frequently associated, and obesity has been considered a factor contributing to both an increase in severity of asthma and to its development. The present document summarizes the proceedings of a symposium held in Montreal, Quebec, on November 2, 2006, under the auspices of the Réseau en santé respiratoire du Fonds de la recherche en santé du Québec in collaboration with the McGill University – Strauss Severe Asthma Program, Université Laval (Quebec City) and Université de Montréal. It includes an overview of the various aspects of the relationships between asthma and obesity with regard to animal models; genetic, hormonal and physiological determinants; influence of comorbidities (eg, sleep apnea syndrome); epidemiology; clinical and psychological features; and management of asthma in the obese population. 相似文献
80.
Jeff SW Wong Calvin SH Ng Tak Wai Lee Anthony PC Yim 《Canadian respiratory journal》2006,13(4):219-221
The present report describes a case of severe airway obstruction caused by endobronchial tuberculosis in an 11-year-old girl who was successfully treated by bronchoscopic balloon dilation. This case illustrates the insidious presentation and the increasingly important role of bronchoscopic intervention in the management of endobronchial tuberculosis. In addition, a brief literature review of the condition in the pediatric age group is included. 相似文献