老年II型糖尿病血脂及血清铁与脑血管动力学变化

1　临床资料　 1999 0 2 / 2 0 0 2 0 1我科住院老年Ⅱ型糖尿病患者 92例 ,全部符合 1997年美国糖尿病协会制定的II型糖尿病诊断标准 .排除其中感染、肿瘤、高血压病、急慢性心功能不全、肾病、肝病、血液系统疾病后 4 5例为研究对象 ,年龄(75± 5 )岁 ,全男性 .糖尿病 1组 19例 ,为单纯糖尿病患者 ,年龄 (74± 6 )岁 ,病程 7～ 12a ;糖尿病 2组 2 6例 ,年龄 (76± 4 )岁 ,病程 (5± 14 )a,其中合并冠心病 18例 ,糖尿病足 3例 ,合并眼底出血 5例 .同期体检身体健康的 4 5例老年人为对照组 ,全男性 ,年龄 (75± 6 )岁 .采血前 2wk停用调脂…     

血清铁和铁蛋白与肝病患者肝纤维化指标的关系

OBJECTIVE: To study the relationship of serum iron and ferritin with the indicators for hepatic fibrosis and hepatic iron overload. METHODS: Liver tissue specimens were obtained from 41 patients with benign (16) or malignant (25) liver diseases by 1 second liver biopsy, and routine microscopic examination was performed after haematoxylin-eosin (HE) and Perl's Prussian staining. Atomic absorption spectrum, radioimmunoassay and enzyme-linked immunosorbent assay were respectively employed to examine the serum levels of iron, ferritin, hyaluronic acid, laminin, human procollagen type , and collagen type . RESULTS: Between patients with benign and malignant liver diseases, significant differences were found in the serum ferritin levels (P < 0.05), but not in serum iron levels (P > 0.05). It was also noted that the levels of the indicators for hepatic fibrosis in patients with benign and early-stage malignant diseases varied significantly from the levels in normal subjects, but these differences were not observed between normal subjects and patients with end-stage hepatic malignancies. Serum iron and ferritin were found to be associated with serum laminin levels (serum iron: r=0.439, P=0.031; serum ferritin: r=0.476, P=0.016), and no iron granules detected in the tissue specimens of hepatocellular carcinoma. CONCLUSIONS: Most of the patients with hepatocellular carcinoma have elevated serum ferritin levels. The serum levels of iron and ferritin are statistically correlated with serum laminin level. Obvious reduction of iron content is typical of hepatic malignant tissues in comparison with the benign tissues, and the reduction in the levels of the indicators for hepatic fibrosis might involve the inhibition of collagen synthesis in the tumor tissues from patients with end-stage hepatocellular carcinoma. Most of the cases of alcoholic fatty liver are complicated by liver iron overload, often marked by serum iron and ferritin levels.     

反复呼吸道感染45例血清微量元素分析

目的探索反复呼吸道感染患儿与微量元素缺乏及喂养的关系。方法对反复呼吸道感染患儿血清微量元素锌、铁、钙水平进行观察,并与对照组进行比较分析,同时对喂养史、添加辅食,有无偏食进行调查并进行统计学分析。结果病例组中的血清铁、锌值低于正常值,异常率明显高于对照组(P<0.05),钙值无明显差异。但在不同喂养、添加辅食,有无偏食状况下微量元素的结果与对照组比较,其异常率高,有极显著性差异(P<0.01)。结论反复呼吸道感染与微量元素锌、铁缺乏有关,且与喂养和生活习惯密不可分。     

低铁与低热量饮食延缓糖尿病肾病的进展

目的探讨低铁与低热量饮食是否能延缓糖尿病肾病的进展。方法以168例Ⅱ型糖尿病肾病患者为研究对象,随机分为两组,对照组予以常规治疗,治疗组在进行同样常规治疗的同时,予低铁、低热量饮食。结果平均随访37±22个月,治疗组患者血清铁水平显著降低,与对照组比较,有显著差异(P<0.01);治疗组血清肌酐189±78μmmol/L,对照组257±115μmmol/L,两组比较,有显著差异(P<0.01)。治疗组有6例患者达到终止随访目标,血红蛋白低于80g/L和或红细胞压积<33%,需进行促红素治疗,占17.6%;对照组有10例达到终止目标,占35.7%,两组比较,有显著差异(P<0.01)。结论低铁饮食治疗能显著降低糖尿病肾病患者铁负荷,配合低热量饮食治疗,能明显延缓糖尿病肾病的进展。     

SPIO标记间充质干细胞3TMR成像

目的：探讨小容积动物线圈3.0T临床磁共振扫描仪体外示踪磁标记间充质干细胞的可行性。方法：用GFP转染法将含有不同剂量铁（56ug／ml和560ug／m1）的超顺磁氧化铁（SPIO）标记间充质干细胞。细胞内铁的含量利用原子吸收谱来测量。磁共振扫描和显微镜可以观察培养试管中的磁标记间充质干细胞。     

母婴铁代谢的研究

通过对孕中期、分娩时妇女及所生婴儿之脐血的检查,提示无论母亲贫血、缺铁与否均不影响脐血的血红蛋白和铁营养指标值,脐血的铁营养指标均显著优于母亲。分组治疗的结果显示,孕中期补铁可以增加孕晚期的铁储备,降低产妇贫血患病率。     

封髓丹铜、锌、铁元素含量及与疗效的关系

<正> 现代医学认为,锌是人体中不可缺少的微量元素之一,如果临床出现缺锌后,DNA 和 RNA 则合成不足,创伤组织中胶原减少,肉芽组织易于破坏,使创伤、瘘管、溃疡及烧伤愈合困难。由此推断,临床常见的慢性口腔溃疡即复发性阿弗它性溃疡可能与缺锌有关。     

哮喘儿童头发锌,铁,铜,钙的含量观察及临床意义

哮喘儿童头发锌、铁、铜、钙的含量观察及临床意义长乐市陈修园医院刘文熙陈兰珍福州市中医院儿科张南近年来我们对哮喘儿童头发的锌、铁、铜、钙值进行检测分析，现将结果报告如下。一、资料与方法（一）资料来源：哮喘患儿组为长乐市陈修园医院及福州市中医院门诊及住院...