训练Wistar大鼠急进高原并运动力竭后血气变化与肺损伤的干预防护研究

本文通过训练大鼠急进高原模型从血气分析与肺的损害,研究干预对训练大鼠肺组织和呼吸功能的损伤与防护。作者在1520m环境设实验组(EG)使用中药抗疲Ⅰ号加入常规饲料中喂养;对照组(CG)常规饲料喂养。EG、CG各40只游泳训练4周后,各选30只3h急进3850m静息1.5h,从中各选10只作为静息对照采集标本,其余EG、CG各20只游泳至力竭后,1h、24h雌雄不分采集股动脉血分析血气。结果:EG与CG相比,血气变化均有显著性差别(P<0.05,P<0.01),肺组织HE染色CG肺泡壁结构不清晰,有红细胞和液体渗出;EG肺泡结构清晰,肺泡内无渗出。这一结果表明:没有防护…     

老年慢性阻塞性肺疾病合并自发性气胸78例临床分析

通过对老年慢性阻塞性肺疾病合并自发性气胸与老年特发性气胸比较，前者气胸类型复杂，治疗困难预后较差。     

何谓药物性肺损害

提到药物的不良反应,人们很自然地会想到胃损害、肝损害和肾损害,而对于肺损害却知之甚少。据统计,药物性肺损害占全身药物不良反应的5%~8%,有的可造成肺组织永久性损害,严重者会危及生命。药物性肺疾病由呼吸科或放射科医生首先发现,其他各科均有发生药物性肺疾病的可能。20世纪60年代以后,药物更新换代加速,而医生对新药的认识和临床应用经验不足,药物的不良反应逐渐增多,药物性肺疾病诊断比较困难,很容易造成漏诊或误诊。本专辑介绍日本对于药物性肺损害最新的一些研究资料,供我国医务人员参考学习。本专辑选译自《日本匾師仝雑誌》2006年第134卷第11号"薬剤性肺障害をめぐって"专辑。由大连医科大学附属第一医院万献尧教授审校。     

厨房卫生误区知多少

1.自来水隔夜用易得“怪病”与腹痛:生活中,不少人都习惯清晨一打开水龙头就用水刷牙、洗脸、做饭,更有甚者,直接饮用自来水。最新的研究却发现,隔夜水龙头往往窝藏有一种名为嗜肺军团杆菌的细菌,人若感染了这种细菌,就会得一种症     

泻血疗法加高频电针点剌引流治疗痤疮135例

目的：观察泻血疗法加高频电针点刺引流治疗痤疮患者的疗效。方法：治疗组135例采用泻血疗法加高频电针点刺引流综合治疗，取穴大椎，肺俞（双），膈俞（双）；对照组150例采用单纯点刺泻血疗法。结果：治疗组治愈率93．3％，对照组治愈率76．0％（P〈0．01）。提示：泻血疗法加高频电针治疗痤疮患者，使用高频电针点刺局部，早期清除瘀滞于痤疮内的分泌物及脓血，可防止炎症侵犯真皮遗留斑痕，同时由于瞬间高温可杀茵消炎而治标。     

量身定做高效循环撮浓缩机组

1 前言 高效循环提取浓缩机组，是一种新型动态提取浓缩机组，采用索氏原理研制而成，商效循环提取浓缩机组主要由提取机及其浓缩机组两大部分构成。主要特点是在提取、浓缩过程中，提取液连续葱提取罐底部被抽入浓缩器，浓缩产生的二次蒸汽经冷凝后不断被送入提取机作为新溶剂，使药材与溶剂之间含有的的可溶性物质始终保持高梯度，以使药材中的溶质高速溶出，达到提取的效果。高效循环提取浓缩机组近年来在制药企业中应用较为广泛，其节能效应普遍受到欢迎。     

多层螺旋CT在鉴别孤立性肺结节中恶性肿瘤的评价

严格意义上讲,孤立性肺结节（solitary pulmo-nary nodule,SPN）是指全肺内唯一的2～30 mm边界清楚的类圆形病灶.但在实际工作和本文叙述中,将呈毛刺状轮廓的孤立病灶也包括在内.在所有SPN中,恶性肿瘤约占40%,良性病变约占60%.但这种比例会受普查人群中肉芽肿性疾病的地方特性和受检人群以及检查方法的影响.就年龄而言,＜35岁患者SPN的恶性肿瘤可能性只占1%～3%,40岁患者良、恶性的概率几乎各占50%.     

PET/CT在评价及观察大鼠肺癌放疗效果中的应用

Objective The aim of this study was to understand the role of PET/CT in monitoring the therapeutic effect of radiotherapy (RT) on lung cancer with Wistar rats. Methods Thirty Wistar in-bred strain rats (6-8 weeks, weighed 180-280 g, female, ordinary) were made into Lewis pulmonary tumor model rats. 18F-fluorodeoxyglucose (FDG) PET/CT was performed when tumor reached 1.5-2.0 cm in greatest diameter (4-6 weeks) as a baseline. In order to get the optimal time point of PET/CT for moni-toring RT effect in rat cancer model, PET/CT was performed at the 3rd day, 1st, 2nd, 3rd, and 4th week after giving single dose of 5 Gy to each rat. Standardized uptake values (SUV) from FDG PET were measured and rats were sacrificed at different time point for validation. Besides, the expressions of glucose transport1 (Glut1) in tumor tissue were studied using immunohistochemistry. The level of tumor cell apoptosis, degra-dation, and necrosis were observed. SPSS 11.0 software was used for data analyses. Results A negative correlation of SUV uptake and time after RT and negative correlation of Glut1 expression and time after RT were observed in rat tumors, respectively. Positive correlation of SUV uptake and Glut1 expression in rat tumors was observed (Spearman rank correlation test, rs = 0.97, P < 0.01). Before RT, the SUV in rat tumor was 1.28 ± 0.31 and was decrease to 1. 00 ± 0.23 at the 3rd day and 0.18 ± 0. 10 at the 4th week after RT (F=15. 126, P<0.05). Before RT, the Glut1 in rat tumor was 0.2558 ±0.03 and was decrease to 0. 2320 ± 0. 01 at the 3rd day and 0. 1320±0.04 at the 4th week after RT. The amounts of tumor cell apopto-sis, degradation, and necrosis increased with time after RT. Conclusion Though FDG PET could monitor the therapeutic effect at the 3rd day after giving single dose of RT to rat lung tumor model, the optimal time was the the 4th week after treatment.