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目的 用^3He-MR成像评价哮喘病人局部气流阻塞随时间的变化,及其与疾病严重程度和应用哮喘药物的关系。方法 该符合HIPAA法案的研究经机构审查委员会同意且所有病人签署了知情同意书。 相似文献
43.
陈海蛟 《现代泌尿外科杂志》2007,12(3):203-203
患有肾病的男性中ED发病率很高。枸橼酸西地那非是勃起功能障碍的高效治疗药物,严重肾功能不全会使该药清除率下降,但在血透治疗的终末期肾病患者中,该药的药代动力学和血液动力学研究尚未见报导。为了研究血透患者中,该药的药代动力学和血流动力学变化,Grossman EB等人让15例慢性门诊血透维持患者在血透前2h及血透后2h口服单剂西地那非,先服哪一次进行随机分配确定。 相似文献
44.
Yulu Miao Mingxia Zhang Yulin Nie Wan Zhao Bin Huang Zhengming Jiang Shaoxiong Yu Zhibin Huang Hongjin Fu 《中国神经再生研究》2007,2(2):126-128
BACKGROUND: Besides local changes of cranial parenchymal cells, hemorrhage, etc., severe traumatic brain injuries also cause the changes of total body fluid and various functions, and the changes of lymphocytes and T lymphocyte subsets should be paid more attention to. OBJECTIVE: To reveal the changing laws of T lymphocyte subsets after severe traumatic brain injury, and compare with mild to moderate brain injury. DESIGN: A comparative observation. SETTINGS: Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City; Central Laboratory of Shenzhen Hospital of Prevention and Cure for Chronic Disease. PARTICIPANTS: All the subjects were selected from the Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City from August 2002 to August 2005. Thirty patients with severe brain injury, whose Glasgow coma score (GCS) was ≤ 8 points, were taken as the experimental group, including 21 males and 9 females, aging 16 - 62 years. Meanwhile, 30 patients with mild traumatic brain injury were taken as the control group (GCS ranged 14- 15 points), including 18 males and 12 females, aging 15 -58 years. All the subjects were in admission at 6 hours after injury, without disease of major organs before injury Informed consents were obtained from all the patients or their relatives. METHODS: (1) The T lymphocytes and the subsets in peripheral blood were detected with immunofluorescent tricolor flow cytometry at l, 3, 7 and 14 days after injury in both groups. (2) The conditions of pulmonary infections were observed at 4 days after injury. The differences of measurement data were compared with the t test. MAIN OUTCOME MEASURES: Changes of T lymphocytes subsets at 1 - 14 days after severe and mild or moderate traumatic injury. RESULTS: Finally, 28 and 25 patients with mild to moderate traumatic brain injury, whereas 25 and 21 patients with severe traumatic brain injury were analyzed at 7 and 14 days respectively, and the missed ones died due to the development of disease. (1) Changes of T lymphocyte subsets: At 1 and 3 days after injury, CD3, CD4, CD8, CD4/CD8 began to decrease, whereas CD8 increased in the experimental group, which were very significantly different from those in the control group (t =2.77 - 3.26, P 〈 0.01), and began to recover at 7 days, which were significantly different from those in the control group (t = 2.06 - 2.24, P 〈 0.05), and generally recovered to the normal levels at 14 days (P 〉 0.05). (2) Conditions of pulmonary infections: At 4 days after injury, the rate of pulmonary infection was significantly different between the experimental group and control group [73% (22/30), 0, x2=37.29, P 〈 0.01]. CONCLUSION: Patients with severe traumatic brain injury suffer from damages of cellular immune function at early period (within 7 days), and they are easily to be accompanied by pulmonary infections. 相似文献
45.
患者女,2l岁,未婚,左眼被汽枪铅弹击伤而入院.检查见左上、下眼险青紫肿胀,左上睑外眦处可见黄豆大伤口,周边不整齐.拍片见左侧筛窦后方有一大小约为0.8cm×0.6cm的金属异物,中线外左侧,鼻根后约3cm;下约1cm局麻下循伤口探查瘘道, 相似文献
46.
随着交通运输及建筑业的发展,创伤日趋增多,且严重而复杂的多发性骨折发生率大幅度上升,我们对四肢多发骨折156例患者进行分析,提出早期全面诊断和早期骨折内固定的治疗观点。[第一段] 相似文献
47.
罗香田 《中华现代中西医杂志》2005,3(2):166-166
外伤闭合性小肠破裂是临床上常见的腹内脏器伤,我院自1985年以来共收治62例,现将诊治体会浅述如下。 相似文献
48.
宫颈病变是女性生殖系统的常见病和多发病,不同类型宫颈病变的发病年龄不同.410医院于1983-01/2003-12对因宫颈严重病变来院就医的川、陕、甘3省毗邻地区妇女作宫颈活检2 593例,现将其临床及病理分类和发病年龄情况报告如下. 相似文献
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