胃镜直视下清创后服药治疗消化性溃疡125例观察

目的：观察胃镜直视下清创对消化性溃疡愈合的影响。方法：２４５例消化性溃疡中治疗组１２５例（胃溃疡５８例,十二指肠球部溃疡６７例）,对照组１２０例（胃溃疡５６例,十二指肠球溃６４例）。治疗组在胃镜直视下用细胞刷反复拉刷溃疡创面,直到创面坏死苔清除干净,其后服药治疗。对照组仅用药物治疗。结果：２周后治疗组消化性溃疡愈合率为７１％,其中胃溃疡为６８％,十二指肠球溃７５％,对照组愈合率５６％（胃溃疡４９％,十二指肠球溃５８％）。１个月后治疗组愈合率为９６％（胃溃疡９４％,十二指肠球溃９８．２％）,对照组为８５％（胃溃疡７２％,十二指肠球溃９１％）。治疗组的２周及１月愈合率明显高于对照组（Ｐ＜０．０５）。胃溃疡清创后愈合率明显优于十二指肠球溃。结论：胃镜直视下清创能加速溃疡愈合,对胃溃疡效果更优。     

Prevalence and natural history of periodontal disease in Scotland – The mediaeval period (900–1600 A. D.)

The periodontal status of a Scottish medieval population was studied. No individual over the age of 11 years had an entirely healthy periodontium. While gingivitis was widespread in the younger age groups, it was essentially a "contained" gingivitis which appeared to progress towards a periodontitis at a fairly constant but slow rate. The pattern of prevalence and distribution of gingivitis and periodontitis was similar to many modern epidemiological studies on natural dentitions but did not support the view that the prevalence of periodontitis in historic material was high. A small proportion of individuals appeared to be either susceptible or resistant to periodontal disease. It was concluded that the study of historic material provides valuable information with regard to the natural history of human periodontal disease.     

大黄消炎痛含漱液对固定矫治患者牙周组织影响的研究

目的观察大黄消炎痛含漱液对固定矫治的患者牙周组织的影响。方法将60例需做正畸治疗的患者分为2组,A组和B组患者戴入矫治器前1周、戴入后2周、4周、8周下颌前磨牙菌斑指数、牙龈出血指数、牙周探诊深度。结果固定矫治器的放置会使牙周临床指标显著增高,牙龈出现轻、中度炎症,应用大黄消炎痛含漱液漱口能使牙周临床指标明显降低。结论固定矫治器的放置可影响牙周组织的健康,对接受固定矫治的患者应用抗菌、消炎药物漱口是非常重要的。     

Bio-Oss结合胶原膜治疗牙周病骨缺损的疗效观察

目的：评价Bio-Oss结合胶原膜治疗牙周病骨下袋的临床疗效。方法：选取慢性牙周炎经过基础治疗后存有牙周骨缺损的患者，随机分为2组。A组采用牙周翻瓣手术并加入Bio-Oss骨粉和胶原膜覆盖治疗，B组只进行翻瓣手术治疗作为对照。分别于术前及术后3、6个月测量各项临床指标。结果：术后2组各项临床指标均有改善，且A组的各项指标明显低于B组，差别具有统计学意义。结论：Bio-Oss结合胶原酶可促进牙槽骨再生及牙周新附着，能有效地修复牙周病骨下袋的骨缺损。     

牙周基础治疗对龈下菌斑中螺旋体及牙周状态影响的研究

目的：动态观测牙周基础治疗对龈下菌斑中螺旋体百分组成及牙周临床指标的影响。方法：对26例牙周病患者78个牙位的龈下菌斑用刚果红染色，计数螺旋体的百分比，记录牙周探诊深度，探诊出血指数和牙齿动度，分析治疗前后的变化。结果：龈上洁治及龈下刮治后1周，龈下菌斑中螺旋体百分比显著下降且牙周临床指数明显改善；刮治后2周，龈下菌斑中螺旋体百分比继续下降，但不具有显著性；刮治后3周，龈下菌斑中螺旋体百分比出现回升趋势。结论：牙周基础治疗是慢性牙周病有效治疗手段；牙周维护治疗对防止牙周再感染和牙周病的复发具有重要意义。     

五倍子水提取物对人牙周膜细胞保护作用的实验研究

目的:观察五倍子水提取物对内毒素(LPS)所致人牙周膜细胞(PDLC)活性降低、超微结构损伤、在牙骨质片表面附着减少、以及碱性磷酸酶(ALP)活性降低的影响,探讨五倍子水提取物对PDLC的保护作用.方法:采用细胞培养技术、3H-TdR掺入法、细胞计数法、透射与扫描电子显微镜技术、酶联免疫技术观察五倍子水提取物对PDLC的保护作用.结果:培养液中加入100μg/mL LPS时,PDLC活性和ALP活性受到明显抑制,超微结构损伤,细胞在牙骨质片表面附着减少.加入五倍子水提取物溶液后,对LPS抑制PDLC活性和ALP活性,以及超微结构损伤、牙骨质片表面附着减少有拮抗作用,该作用随五倍子水提取物浓度增加而增加,到10μg/mL时,达到峰值.结论:五倍子水提取物对PDLC具有保护作用,有望成为防治牙周病的药物.     

伊朗传统医学治疗牙周疾病

目的:牙周疾病非常普遍,尽管有各种特定的治疗方法,但我们始终面临治疗方法有限的问题。考虑到世界组织十分关注传统医学在医疗服务中的发展和应用,我们在一直考察研究伊朗传统医学中药物对牙周疾病的治疗作用。方法:此项研究是一个对有关方面书籍的综合论述,伊朗传统医学内容是经过对重量级作者如Avicenna和Alzahrawy所著的有价值的书籍修订,收集了各医学院校馆藏图书和医药公司的有关信息编辑而成,因为在伊朗传统医学中牙周疾病分成不同目类,对有关药物的研究也被分成8个大组63个题目。(1)缓解牙龈肿胀药物(2)治疗牙龈恶化药物(3)治疗口疮腐烂药物(4)治疗牙龈肥大药物(5)利于伤口康复药物(6)利于牙龈加固的药物(7)阻止牙龈出血的药物(8)防止牙齿松动药物。结果结论:伊朗传统医学在准确的观察和实践的基础上来描述和治疗牙周疾病的。在制药学、有效治疗方面、科学研究手段等领域,伊朗传统医学在以下几个方面可作为现代制药研究的重要资源:(1)纯天然资源(2)容易获得(3)相对比较安全。     

透明质酸在牙周组织创伤愈合过程中的作用

目的:介绍透明质酸在牙周组织创伤愈合过程中的作用.方法:查阅国内外有关文献,进行分析、归纳和综述.结果:透明质酸发挥着抗炎、抗感染、抗水肿、促进组织重建和创伤愈合的作用.结论:透明质酸可促进牙周组织的愈合和修复.     

Periodontal ligament stem/progenitor cells with protein-releasing scaffolds for cementum formation and integration on dentin surface

ABSTRACT

Purpose/Aim: Cementogenesis is a critical step in periodontal tissue regeneration given the essential role of cementum in anchoring teeth to the alveolar bone. This study is designed to achieve integrated cementum formation on the root surfaces of human teeth using growth factor–releasing scaffolds with periodontal ligament stem/progenitor cells (PDLSCs). Materials and methods: Human PDLSCs were sorted by CD146 expression, and characterized using CFU-F assay and induced multi-lineage differentiation. Polycaprolactone scaffolds were fabricated using 3D printing, embedded with poly(lactic-co-glycolic acids) (PLGA) microspheres encapsulating connective tissue growth factor (CTGF), bone morphogenetic protein-2 (BMP-2), or bone morphogenetic protein-7 (BMP-7). After removing cementum on human tooth roots, PDLSC-seeded scaffolds were placed on the exposed dentin surface. After 6-week culture with cementogenic/osteogenic medium, cementum formation and integration were evaluated by histomorphometric analysis, immunofluorescence, and qRT-PCR. Results: Periodontal ligament (PDL) cells sorted by CD146 and single-cell clones show a superior clonogenecity and multipotency as compared with heterogeneous populations. After 6 weeks, all the growth factor–delivered groups showed resurfacing of dentin with a newly formed cementum-like layer as compared with control. BMP-2 and BMP-7 showed de novo formation of tissue layers significantly thicker than all the other groups, whereas CTGF and BMP-7 resulted in significantly improved integration on the dentin surface. The de novo mineralized tissue layer seen in BMP-7-treated samples expressed cementum matrix protein 1 (CEMP1). Consistently, BMP-7 showed a significant increase in CEMP1 mRNA expression. Conclusion: Our findings represent important progress in stem cell–based cementum regeneration as an essential part of periodontium regeneration.