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排序方式: 共有719条查询结果,搜索用时 664 毫秒
61.
目的 探讨金嗓散结丸治疗声带白斑的临床疗效.方法 选择2001年3月~2009年10月我院耳鼻喉科门诊经动态喉镜检查证实为声带白斑的病人97例,病史1~6个月不等,治疗组67例,采用中成药金嗓散结丸治疗,9g·次-1,tid,疗程4~8 w;对照组30例,使用金果饮,20 mL·次-1,tid,疗程与治疗组相同,两组均予以地塞米松5 mg及庆大霉素8万U喉超声雾化吸入.结果 治疗组,有效56例,占83.58%,其中治愈39例,占58.21%;对照组,有效6例,占20.00%,其中治愈1例,占3.33%.结论 金嗓散结丸对早期声带白斑疗效确切、疗法安全简便、费用低廉,值得推广. 相似文献
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63.
Lima Gda S Silva GF Gomes AP de Araújo LM Salum FG 《Journal of applied oral science : revista FOB》2010,18(5):533-537
Objective
Actinic cheilitis (AC) is a precancerous lesion of the lip vermillion caused by prolonged exposure to ultraviolet light. The aim of this study was to evaluate the effect of 3% diclofenac in 2.5% hyaluronic acid gel in the treatment of AC.Methods
Thirty-four patients with chronic AC were treated twice a day with topical diclofenac during a period of 30 to 180 days. The individuals were followed up every 15 days by means of clinical examination and digital photographic documentation.Results
Of the 27 patients that completed the study, 12 (44%) showed complete remission of the whitish plaques and exfoliative areas, and 15 (56%) had partial remission of the clinical picture of cheilitis. The latter group was submitted to excision of the leukoplakic areas which diagnosis varied from mild to moderate epithelial dysplasia.Conclusion
The results suggest a promising role for diclofenac in hyaluronic acid gel in the treatment of AC. This treatment has the advantages of not being invasive and showing few side effects. 相似文献64.
Aldini Beuting Pereira Kitahara Arieli Carini Michels Suelen Teixeira Luiz Seigo Nagashima Ana Paula Camargo Martins Marina Luise Viola de Azevedo Luciana Reis Azevedo Alanis Paulo Henrique Couto Souza Sérgio Aparecido Ignácio Lucia de Noronha Patrícia Vida Cassi Bettega Maria Carolina Albini Tyski Edinson Manuel Pérez Quispe Izabela Mozzer Giovanna Ribeiro Souto Maria Cássia Ferreira Aguiar Filipe Modolo Rafaela Scariot Bruno Correia Jham Ana Maria Trindade Grégio Hardy Aline Cristina Batista Rodrigues Johann 《Oral diseases》2023,29(2):376-379
65.
66.
Recent new terminologies have been proposed for lesions in the sphere of oral lichen planus (OLP) that theoretically present unique aetiological, clinical, prognostic or management characteristics different from those of the so-called typical forms of OLP. We aimed to critically analyse what concepts and terminologies related to OLP should we accept based on the available evidence. A review of the literature was carried out in order to critically analyse the concepts and terminologies related to OLP. New concepts and terminologies include oral lichenoid lesions; contact lichenoid reactions, drug lichenoid reactions or those in the context of graft-versus-host disease; chronic ulcerative stomatitis; lichen planus pemphigoid; and some lesions that are difficult to categorise, such as OLP with features of proliferative verrucous leukoplakia and lichenoid lesions of the upper labial mucosa. A multidisciplinary, multicontinent working group has recently published a guideline with recommendations for modifying definitions and terminologies associated with a disease, among which a reasoned, evidence-based justification for the proposed change is considered essential. An in-depth analysis of the newly proposed terms for OLP-related lesions shows that many of them are not justified. In this paper, we set out our position on the basis of the existing evidence on the appropriateness of the use of these new terms. 相似文献
67.
Majumder M Sikdar N Ghosh S Roy B 《International journal of cancer. Journal international du cancer》2007,120(10):2148-2156
Polymorphisms at N-acetyl transferase 2 locus (NAT2) lead to slow, intermediate and rapid acetylation properties of the enzyme. Improper acetylation of heterocyclic and aromatic amines, present in tobacco, might cause DNA adduct formation. Generally, DNA repair enzymes remove these adduct to escape malignancy. But, tobacco users carrying susceptible NAT2 and DNA repair loci might be at risk of oral leukoplakia and cancer. In this study, 389 controls, 224 leukoplakia and 310 cancer patients were genotyped at 5 polymorphic sites on NAT2 and 3 polymorphic sites on each of XRCC1 and XPD loci by PCR-RFLP method to determine the risk of the diseases. None of the SNPs on these loci independently could modify the risk of the diseases in overall population but variant genotype (Gln/Gln) at codon 399 on XRCC1 and major genotype (Lys/Lys) at codon 751 on XPD were associated with increased risk of leukoplakia and cancer among slow acetylators, respectively (OR = 4.2, 95% CI = 1.2-15.0; OR = 1.6, 95% CI = 1.1-2.3, respectively). Variant genotype (Asn/Asn) at codon 312 on XPD was also associated with increased risk of cancer among rapid and intermediate acetylators (OR = 1.9, 95% CI = 1.2-2.9). Variant C-G-A haplotype at XRCC1 was associated with increased risk of leukoplakia (OR = 1.7, 95% CI = 1.2-2.4) but leukoplakia and cancer in mixed tobacco users (OR = 3.1, 95% CI = 1.4-7.1, OR = 2.4, 95% CI = 1.1-5.4, respectively) among slow acetylators. Although none of the 3 loci could modulate the risk of the diseases independently but 2 loci in combination, working in 2 different biochemical pathways, could do so in these patient populations. 相似文献
68.
S.-W. Yang Y.-S. Lee L.-C. Chang H.-P. Chien T.-A. Chen 《International journal of oral and maxillofacial surgery》2013,42(6):693-701
This study aimed to investigate the clinical efficacy of using broadband white light (BWL) to observe morphologic appearance, narrow-band imaging (NBI) to observe intraepithelial microvasculature, and both BWL and NBI for the detection of high-grade dysplasia and carcinoma in oral leukoplakia. Among 317 patients (274 males and 43 females; aged 52.4 ± 10.7 years), the odds ratio (95% confidence interval) for detecting high-grade dysplasia and carcinomatous lesions based on morphologic appearances of BWL, and microvasculature patterns of NBI, were 39.12 (9.33–64.10), and 97.16 (38.19–247.21), respectively, which were significantly better than BWL (p < 1 × 10?15). The sensitivity, specificity, positive and negative predictive values, and accuracy of use of traditional BWL classification, NBI classification, and combined BWL and NBI classification for detecting high-grade dysplasia and carcinomatous lesions were 96.30, 60.08, 33.12, 98.75, 66.25, 39.92, and 3.70%; 87.04, 93.54, 73.44, 97.23, and 92.43%; and 100.00, 60.08, 33.96, 100.00, and 66.88%, respectively. In conclusion, the diagnostic accuracy by NBI classification of oral leukoplakia based on the intraepithelial microvasculature patterns is significantly better than BWL indicating that NBI is a promising non-invasive tool in detecting high-grade dysplasia and carcinomatous lesions in oral leukoplakia. 相似文献
69.
70.
M. J. E. M. F. Mabruk S. R. Flint M. Toner I. Balluz D. Coleman D. Sullivan G. J. Atkins 《Journal of oral pathology & medicine》1994,23(7):302-308
The definitive diagnosis of oral hairy leukoplakia (OHL) demands that Epstein-Barr virus (EBV) is demonstrated in the lesional tissue, since the histopathological features on conventional light microscopy are not pathognomonic. We have investigated the possible use of polymerase chain reaction (PCR) technology in reaching a definitive diagnosis of this lesion by its application to ten biopsy specimens with definitive diagnoses of OHL determined by in situ hybridization. EBV DNA was demonstrated by PCR in all ten OHL biopsy specimens analysed, and none of ten control specimens. Furthermore, we have investigated the role of PCR in analysis of exfoliative cytology samples collected from the lateral border of the tongue by a minimally-invasive scraping technique. EBV DNA was not only detected in all OHL lesional scrapings but also in more than one-third of healthy controls, due to viral presence in saliva at the time of sampling. In this application, the highly sensitive PCR technique has low specificity and cannot be recommended. 相似文献