Polyvinyl chloride dermatitis not caused by phthalates

Seven cases of contact dermatitis in children due to identification bracelets made of poly-vinyl chloride plastic are reported. Patch tests with the bracelets were negative in the five cases tested. It is concluded that the reactions were irritant due to some unknown chemical in the bracelets.
The most widely used plasticizers in PVC, phthalates, must have very low sensitising properties, as only one positive patch test was found in 1532 patch tests with phthalate mix, performed as a joint study by the International Contact Dermatitis Research Group.     

Liposuction for axillary hyperhidrosis

Excessive axillary sweating is a common problem for which many patients frequently seek dermatological advice. The removal of axillary sweat glands using liposuction with tumescent anaesthesia in an outpatient setting is a relatively short and simple procedure with few complications, as seen in this case series. We present 10 patients treated with axillary liposuction under tumescent anaesthesia. Of the 10 patients treated, four relapsed with axillary hyperhidrosis and required additional liposuction to the same area. The longest time to relapse was 15 months, with 4 months being the shortest time. Six patients have not required additional liposuction, with 7 years being the longest time of remission. The complications reported were bruising in the axillae of two patients and relapse of hyperhidrosis in four patients.     

Photocontact dermatitis to cobalt salts

4 patients with chronic photocontact dermatitis were sensitive to cobalt salts. They presented as cases of contact dermatitis from cement or pig fodder with persistent lesions on exposed areas. Only 2 of them had standard patch test positive reactions to chromate and cobalt, but all showed positive photo-patch tests to cobalt. Photo-oxidation tests proved that cobalt salts are photosensitizing. Exposure to cobalt salts was responsible for the patients' chronic actinic dermatitis.     

Allergic contact dermatitis from di-isodecyl phthatate in a polyvinyl chloride identity band

An animal model for the evaluation of skin protective creams against chemical irritants is described. The irritants were applied daily for 2 weeks to shaved back skin of young guinea pigs: sodium tauryl sulphate (5% aq.: 30 min), sodium hydroxide (0,5% aq.; 2 min). and toluene (20′i. eth.; 2 mint. “The harrier cream was applied 2 h prior to and immediately after exposure to the irritant. Control animals were treated with the irritant only. The irritant reaction was scored on a 4–point scale for erythema and quantified with regard to transepidennal water loss (TEWL) by evaporime-try and skin blood flow volume (BFV) by laser Doppler velocimetry. A total of 90 guinea pigs, consisting of” individual panels of 5 to 10 animals, was tested. While one barrier cream (Slokoderm) significantly suppressed the irritation due 10 sodium lauryl sulphate and toluene, the other (Contra-Alkalh failed to do so and even aggravated the response, which was particularly evident with sodium hydroxide. This model may be useful in developing more effective barrier creams.     

Reserpine and the suppression of both edema formation and cellular infiltrate of the contact sensitivity reaction in the mouse

Summary Reserpine treatment in doses of 1.0 and 5.0 mg/kg body weight, given 6 h before antigen challenge significantly suppresses the contact sensitivity reaction to picryl chloride in sensitized mice. The suppression involves both the edema formation, measured as ear swelling, and the accumulation of inflammatory cells at the test site. This is probably mediated through inhibition of the release of vasoactive amines from local mast cells.     

先天性肌强直两家系的临床分析及CLCN1基因突变检测

目的研究先天性肌强直(MC)两家系的临床特点及CLCN1基因突变情况。方法对两个MC家系7例患者的临床资料进行分析。从两个家系成员及100例正常对照者外周静脉血中提取基因组DNA,通过PCR及DNA测序对CLCN1编码区进行突变分析。结果两个家系的7例患者均为幼年起病的肌强直与运动笨拙,伴有肌肥大和扣击性肌球,肌电图示肌强直电位发放。基因检测发现先证者1及家系1其他患者在第8外显子892位核苷酸处发生G-A杂合突变,使298位丙氨酸被苏氨酸代替(A298T)。而另一家系患者及其他健康成员CLCN1基因23对外显子直接测序均未发现有突变存在。结论在中国MC家系中发现了新的CLCN1突变位点,为研究中国人群CLCN1突变类型、遗传方式提供了一定的参考。     

Observation of changes in the number of myocardial capillaries in rabbits after treatment of acute myocardial infarction by Tongxinluo superfine powder

OBJECTIVE

To investigate the effects of Tongxinluo superfine powder on cardiac function, infarct size and the number of myocardial capillaries in a rabbit model of acute myocardial infarction.