Periodontal repair in dogs Effect of heparin treatment of the root surface

Studies on periodontal repair to denuded root surfaces have suggested that initial clot adhesion to the root surface may be important for the nature of subsequent healing. To study this hypothesis, circumferential periodontal defects, approximately 5 mm in vertical dimensions, were surgically created and immediately treated around the mandibular premolars in 4 beagle dogs. Prior to wound closure, the root surfaces were treated with either the anticoagulant heparin or with saline. Tissue blocks were obtained at sacrifice 4 weeks after surgery. Histometric analysis showed that connective tissue repair to the root surface averaged 50% of the defect height for heparin-treated teeth as compared to 95% for saline-treated teeth. Junctional epithelium amounted to an average of 33% of the defect height in heparin-treated teeth in contrast to 5% following saline treatment. It can be concluded that heparin treatment of the root surface compromises connective tissue repair, confirming clot adhesion as one prerequisite for connective tissue repair of periodontal defects.     

气相色谱法测定根面龋中有机酸含量

目的：利用气相色谱分析法对根面龋牙本质标本中的有机酸作定性定量测定。方法：３０ 名患者（ 年龄４５ ～７８ 岁）的４４ 个牙齿的根面龋牙本质标本，以２５ｇ／Ｌ 偏磷酸溶解，低温离心（１０ ０００ｒ／ｍｉｎ，４ ℃，１０ｍｉｎ），上清液作气相色谱分析。结果：大多数根面龋标本中均检测到乳酸、甲酸、乙酸、丙酸和丁酸，少数标本中还检测到戊酸。各有机酸含量由高到低依次为甲酸（１９ ．１１±４ ．７１）ｇ／Ｌ；乙酸（２ ．７６ ±１ ．３８）ｇ／Ｌ；丙酸（１．１８ ±０ ．８４）ｇ／Ｌ；乳酸（１ ．０５ ±１．２）ｇ／Ｌ；丁酸（０ ．８１ ±０ ．４２）ｇ／Ｌ；戊酸（０．０４ ±０．１５）ｇ／Ｌ。结论：根面龋中的有机酸以甲酸、乙酸和丙酸为主，占各有机酸含量的９２ ．４ ％ ，主要是细菌利用龋损中胶原等内源性物质而产生的。     

Therapeutic effects of combined treatment using tetracycline-immobilized collagen film and root planing in periodontal furcation pockets

46 upper and lower molars with furcation grade II involvement were selected from 16 patients with periodontal disease. The teeth were randomly allocated to the following groups according to treatment; (1) 4 consecutive administrations of tetracycline-immobilized cross-linked collagen film (TC film) at intervals of 1 week (TC group); (2) 1 root planing treatment (RP group); (3) combination treatment (TC + RP group); (4) no treatment (control group). The therapeutic effects of each treatment were compared both clinically and microbiologically. Records of plaque index, gingival index, bleeding on probing, probing depth, probing attachment level and microscopic counts were obtained at 0, 4, 6 and 8 weeks. The results showed marked decreases in probing depth and density of micro-organisms in both the RP and TC + RP groups. In particular, the TC + RP group was characterized by a decreased rate of bleeding on pocket probing and an increased probing attachment gain. The above findings demonstrated that root planning is effective in the treatment of furcation involvement and that the effects are enhanced by the local administration of TC films.     

A comparison of magnetic and electrical stimulation of spinal nerves

The utility of the magnetic coil for stimulation of the cervical spinal nerves was compared to electrical stimulation by a monopolar needle cathode placed onto the spinal lamina in six volunteers. No statistical difference in average amplitudes or areas of evoked CMAPs was found although the size of the magnetic coil evoked potentials was less at C7-8 in several subjects. Electrical stimulation resulted in depolarization at a more proximal site. Electrical stimulation was associated with more discomfort, especially at C5-6. We conclude that electrical stimulation using a monopolar needle as the cathode is the superior technique for the clinical electrophysiologic study of the proximal brachial plexus and cervical spinal nerves.     

Medullary monoamine levels during experimental tooth movement

We investigated possible influence of nociception induced by experimental tooth movement on the medullary monoaminergic inhibitory systems. Forty-eight hours after the start of the experimental tooth movement, significant increases in dorsal serotonin (5-HT), dopamine (DA), norepinephrine (NE), 5-hydroxyindoleacetic acid (5-HIAA), and dihydroxyphenylacetic acid (DOPAC) levels were detected with ipsilateral dominance. These results suggest that the nociception induced by experimental tooth movement might be under modulation of serotonergic, noradrenergic, and dopaminergic systems.     

刺五加注射液治疗肺源性心脏病急性加重期疗效观察

目的:观察刺五加注射液治疗肺源性心脏病(肺心病)急性加重期的临床疗效。方法:将64 例患者随机分为2 组,各32 例。2 组均予吸氧、抗感染、强心、利尿、解痉平喘、纠正电解质和酸碱失衡等对症治疗。治疗组加用刺五加注射液40 m l(加入5% 葡萄糖盐水250 m l中)静滴,每日1 次,10 次为1 个疗程。结果:治疗组总有效率为84.4% ,显著高于对照组总有效率59.4% (χ2= 4.95,P< 0.05)。治疗组治疗后全血粘度、全血还原粘度及红细胞聚集指数均较对照组治疗后显著降低(P 均< 0.05);动脉血氧分压(PaO2)显著升高,二氧化碳分压(PaCO2)显著降低,与对照组治疗后比较也有显著性差异(P 均< 0.05)。结论:肺心病急性加重期患者在西医综合治疗基础上加用刺五加注射液可提高临床疗效,改善血液流变性和血气指标。     

Root formation by tooth germs following extraction of prematurely erupted upper first premolars. Case report

A case is described of a seven year-old boy in whom root formation continued following the premature extraction of both maxillary first premolars.     

直丝弓技术矫治安氏Ⅱ类Ⅰ分类错

目的 :总结直丝弓技术矫治安氏Ⅱ类Ⅰ分类拔牙病例的疗效。方法 :对20例年龄在14～25岁的骨性Ⅱ类Ⅰ分类病例 ,采用上颌拔除第一双尖牙 ,下颌拔除第二双尖牙 ,依据直丝弓技术矫治原则和顺序进行矫治。结果 :20例患者平均矫治时间为16 4个月 ,矫治后均达到了理想的侧貌外形 ,磨牙关系由Ⅱ类改变为Ⅰ类。前牙覆盖覆牙合正常 ,咬牙合关系良好。ANB角由平均5 4°±1 1°改变为3 1°±1 2°,Z角由60 3°±2 4°改变为74 2°±2 2°,AO -BO距离由6 6±2 1mm改变为3 0±1 0mm。结论 :临床使用直丝弓技术矫治安氏Ⅱ类Ⅰ分类拔牙病例 ,是行之有效的 ,且具有操作简单 ,缩短疗程的特点     

间断鞘内注射不同浓度罗哌卡因对大鼠脊髓及神经根早期超微结构的影响

目的观察鞘内间断注射不同浓度罗哌卡因对大鼠脊髓、神经根早期超微结构的影响。方法雄性SD大鼠24只,按改良Yaksh法置入导管至脊髓腰段鞘内8 cm。随机分为4组(n=6):N 组(对照组)经导管注入0.9%氯化钠40μl,每1.5 h一次,共3次。R1、R2、R3注药方式同N组,分别注入0.5%、0.75%、1%罗哌卡因40μl。各组在注药后6 h取腰膨大处1mm3脊髓及神经根,电镜下观察其早期超微结构变化。结果N、R1、R2组脊髓、神经根早期超微结构基本正常。R3组大多数神经元细胞固缩,大多数粗面内质网扩张,线粒体及内质网结构模糊,有少数神经元细胞完全变性;部分有髓神经纤维变性,板层结构疏松;雪旺氏细胞固缩。与R3组比较,N、R1、R2组神经元胞质空泡形成或变性评分、灰质内空泡评分、髓鞘丢失断裂评分、内、外轴膜清晰度评分及神经根空泡变性评分均降低(P<0.05),而灰质内出血评分差异无统计学意义(P>0.05)。N、R1、R2组间以上评分比较差异无统计学意义(P>0.05)。结论0.5、0.7%罗哌卡因间断鞘内注射对大鼠脊髓、神经根超微结构无明显影响,1%罗哌卡因则可造成脊髓损害。