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41.
To describe the association between coding and classification practices and observed stage-specific incidence and survival trends in Norway over time.We identified all women diagnosed with invasive breast cancer in the period between 1980 and 2015. Changes in the coding and classification of breast cancer in the study period were described, and stage-specific incidence rates and relative survival were calculated.A total of 90 362 women were diagnosed with primary breast cancer, stage I–IV, or unknown stage, in the study period. Stage-specific incidence was significantly influenced by changes in coding practice, classification systems and the implementation of the screening program. These changes have mostly affected the proportion of stage I and “unknown”, but also stages II, III and IV. The proportion of stage I showed a clear increase during the implementation period of the national screening program, and was most pronounced within the age group 50–69. Stage-specific trends for relative survival were less influenced by changes in coding and classification of stage.Our study showed that the stage-specific incidence trends in Norway were influenced by changes in the coding and classification practice. These findings should be taken into consideration in future research and evaluation related to stage-specific trends and stage migration of breast cancer in Norway. 相似文献
42.
目的:考察苦黄缓释微丸的制备及其质量指标。方法:利用流化床包衣设备,采用薄膜包衣法制备苦黄缓释微丸,以总蒽醌为指标性成分,测定缓释微丸的释放度,并考察了包衣处方工艺因素对药物释放的影响。结果:流化床薄膜包衣法成功制备了苦黄缓释微丸,其Eudragit RS 30D与Eudragit RL 30D的用量比例为1∶0时,包衣增重为14%;累积释放百分率2h26%,6h70%,12h90%。结论:水性薄膜包衣技术制备苦黄缓释微丸,具有良好的体外缓释行为。 相似文献
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Lívia Samara dos Reis Rodrigues Okada Claudia P. Oliveira José Tadeu Stefano Monize Aydar Nogueira Ismael Dale Cotrim Guerreiro da Silva Fernanda Bertucce Cordeiro Venâncio Avancini Ferreira Alves Raquel Susana Torrinhas Flair José Carrilho Puneet Puri Dan L. Waitzberg 《Clinical nutrition (Edinburgh, Scotland)》2018,37(5):1474-1484
45.
Patterns of cortical thickness associated with impulse control disorders in Parkinson's disease
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Roberta Biundo PhD Luca Weis PhD Silvia Facchini BS Patrizia Formento‐Dojot BS Annamaria Vallelunga BS Manuela Pilleri MD Daniel Weintraub MD PhD Angelo Antonini MD PhD 《Movement disorders》2015,30(5):688-695
Previous functional neuroimaging studies in Parkinson's disease (PD) patients with impulse control disorders (ICDs) demonstrated dysfunction of the reward network, although the extent of anatomical changes is unclear. The aim of this study was to measure brain cortical thickness and subcortical volumes, and to assess their relationship with presence and severity of symptoms, in PD patients with and without ICDs. We studied 110 PD patients (N = 58 with ICDs) and 33 healthy controls (all negative for ICDs) who underwent an extensive neurological, neuropsychological, and behavioral assessment as well as structural 1.5 Tesla magnetic resonance imaging (MRI). Between‐group differences in brain cortical thickness and subcortical volumes, assessed with the FreeSurfer 5.1 tool, were analyzed. In patients with ICDs, we found significant cortical thinning in fronto‐striatal circuitry, specifically in the right superior orbitofrontal, left rostral middle frontal, bilateral caudal middle frontal region, and corpus callosum, as well as volume reduction in the right accumbens and increase in the left amygdala. Finally, we observed a positive association relationship between severity of impulsive symptoms and left rostral middle frontal, inferior parietal, and supramarginal areas. These results support the involvement of both reward and response inhibition networks in PD patients with ICDs. Moreover, their severity is associated with alterations in brain regions linked with reward and top‐down control networks. Increased understanding of the mechanisms underlying impulsive and compulsive behaviors might help improve therapeutic strategies for these important disorders. © 2015 International Parkinson and Movement Disorder Society 相似文献
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47.
Fernando Mallmann Luciano Rosa Márcia Borba Alvaro Della Bona 《The Journal of prosthetic dentistry》2018,119(1):124-131
Statement of problem
The effect of screw-access holes and mechanical cycling on fracture resistance of 3-unit screw-retained zirconia-based implant-supported fixed dental prostheses (ISFDPs) is unknown.Purpose
The purpose of this in vitro study was to evaluate the effect of screw-access holes on the maximum fracture load (Lf) of 3-unit ISFDPs fabricated with the same abutment design for screw (s)-retained and cement (c)-retained with either a metal- or zirconia-based framework, testing the hypotheses that ISFDPs with screw-access holes have the lowest Lf and that mechanical cycling decreases the Lf of screw-retained ISFDPs.Material and methods
Models with fiberglass bases with 2 implants were fabricated. Special abutments were designed to allow for both s- and c-retained ISFDPs. The study considered the type of framework (s-retained metal-based and s-retained zirconia-based), fixation (s and c), and aging (a) with mechanical cycling, resulting in the following experimental groups (n=12): c-retained metal-based ISFDP; s-retained metal-based ISFDP (Ms); s-retained zirconia-based ISFDP aged by mechanical cycling (Zsa); and s-retained metal-based ISFDP aged by mechanical cycling (Msa). All ISFDPs were porcelain veneered and subjected to compressive load to failure. Fracture load data were statistically analyzed using 1-way ANOVA and Tukey range tests (α=.05). Fractography was used to evaluate the fracture surfaces.Results
Cement-retained ISFDP (Zc and Mc) showed the greatest Lf values (P<.001). Zs prostheses showed higher Lf values than those for Ms. Aging significantly decreased the Lf of Zsa but had no effect on Msa. Chipping was the failure mode most frequently found. Only Zs and Zsa ISFDPs showed catastrophic failures.Conclusions
ISFDPs with screw-access holes showed lower Lf values, regardless of the framework type. Mechanical cycling affected the Lf of screw-retained zirconia-based ISFDPs. 相似文献48.
49.
Mariana B. Zilio Tatiana F. Eyff André L.F. Azeredo-Da-Silva Vivian P. Bersch Alessandro B. Osvaldt 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2019,21(3):259-267