终末期肝病模型评估肝硬化食管静脉曲张破裂大出血硬化治疗预后价值的比较

目的 评价CTP、终末期肝病模型(MELD)、MELD-As、MELD-Na、i-MELD以及MESO在判断肝硬化食管静脉曲张破裂出血行内镜下硬化治疗术(EIS)患者预后方面的价值.方法 在行急诊EIS的肝硬化食管静脉曲张破裂大出血患者中,选取有完整临床资料和随访结果的78例患者进行回顾性分析,应用受试者工作特征(ROC)曲线及曲线下面积评价上述各模型在判断行急诊EIS患者预后的准确性.获取各模型判断患者预后的最佳临界值.结果 78例患者中随访6、12个月,分别死亡8例(10.26%)、11例(14.10%).在随访6、12个月中,生存患者与死亡患者年龄、性别构成比较差异无统计学意义.判断患者预后时,ROC曲线下面积值大于0.800的模型,6个月为MELD-AS(0.837)、MESO(0.830)、MELD(0.830)、MELD-Na(0.818);12个月为MELD(0.822)、MELD-AS(0.821)、MESO(0.814).结论 MELD-AS、MESO及MELD在判断急诊EIS患者6、12个月的预后方面准确度较高,是该类患者中短期死亡风险的较好判断指标,亦可作为临床EIS术前的筛选指标,具有一定的临床指导意义.     

重组人表皮生长因子不同剂型作用于糖尿病溃疡动物模型的疗效比较

目的比较重组人表皮生长因子（rhEGF）不同剂型作用于糖尿病溃疡动物模型创面的疗效差别。方法建立糖尿病溃疡动物模型,将模型随机分为重组人表皮生长因子水剂组和重组人表皮生长因子凝胶组,动态观察重组人表皮生长因子水剂组和重组人表皮生长因子凝胶组对溃疡面积、愈合时间及动态愈合率的影响。结果重组人表皮生长因子凝胶组在溃疡的面积变化、愈合时间及动态愈合率方面均较重组人表皮生长因子水剂组差异有显著性意义（P〈0.01）。结论重组人表皮生长因子凝胶比重组人表皮生长因子水剂更能促进糖尿病溃疡创面的愈合。     

甘草提取液对糖尿病大鼠肾脏的保护作用

目的 观察甘草提取液对糖尿病大鼠肾脏的保护作用及其机制。方法 Wistar大鼠48只随机分为对照组、模型组和治疗组,每组16只。于第8周及第12周测定各组大鼠的肾质量指数（KI）、葡萄糖氧化酶法测定空腹血糖（FBG）、微柱法测定糖化血红蛋白（GHbA1c）、考马斯亮兰法测定24h尿白蛋白量、速率法测定血和尿肌酐、硫代巴比妥酸法测定血液及肾组织匀浆中丙二醛（MDA）含量、黄嘌呤氧化酶法测定血液及肾组织匀浆中超氧化物歧化酶(SOD)活性、比色法测定血液及肾组织匀浆中硒谷胱甘肽过氧化物酶（SeGSHPx）和醛糖还原酶（AR）活性、计算内生肌酐清除率（Ccr）。结果 与对照组相比,模型组及治疗组所有指标的差异均有统计学意义（P均＜0.05）。与模型组相比,治疗组KI、FBG、GHbA1c、24h尿白蛋白量、Ccr、血液及肾组织匀浆中MDA含量、AR活性均显著降低（P均＜0.05）,SOD、SeGSHPx活性均显著升高（P均＜0.05）。结论 甘草提取液对糖尿病大鼠具有肾脏保护作用,其机制与调节血糖、降低肾脏AR活性、提高肾脏抗氧化能力有关。     

Testing the Transtheoretical Model in Predicting Smoking Relapse among Malaysian Adult Smokers Receiving Assistance in Quitting

The role of The Transtheoretical Model (TTM) in predicting relapse is limited. We aimed to assess whether thismodel can be utilised to predict relapse during the action stage. The participants included 120 smokers who hadabstained from smoking for at least 24 hours following two Malaysian universities’ smoking cessation programme.The smokers who relapsed perceived significantly greater advantages related to smoking and increasing doubt intheir ability to quit. In contrast, former smokers with greater self-liberation and determination to abstain wereless likely to relapse. The findings suggest that TTM can be used to predict relapse among quitting smokers.     

Comparison of Two Ovarian Malignancy Prediction Models Based on Age Sonographic Findings and Serum Ca125 Measurement

Objective: The aim of our study is to compare an ovarian malignancy prediction model based on age andfour sonographic findings (OMPS1) with a new model called OMPS2 which differs just by adding serum CA125measurement to (OMPS1). Methods: In a cross sectional comparative study OMPS1 was validated in 830 operatedovarian masses within a 3 years period (2006-2009). Logistic regression analysis was used to construct OMPS2based on OMPS1 adding serum CA125 findings. The area under the curve for two models was compared in411 patients. Results: OMPS2 was calculated as follows: OMPS1 + 1.444 (if serum CA125= 36-200) or 3.842 (ifserum CA125 is more than 200). AUC of OMPS2 was increased to 84.3% (CI 95% 78.1- 89.8) in comparison toOMPS1 with AUC of 78.1% (CI 95% 71.8-84.5). Conclusion: Our second model is more accurate in predictionof ovarian malignancy, compared with our first model.     

Predictors of the outcomes of acute-on-chronic hepatitis B liver failure

AIM:To identify the risk factors in predicting the outcome of acute-on-chronic hepatitis B liver failure patients.METHODS:We retrospectively divided 113 patients with acute-on-chronic liver failure-hepatitis B virus(ACLF-HBV) and without concurrent hepatitis C or D virus infection and hepatocellular carcinoma into two groups according to their outcomes after anti-HBV therapy.Their demographic,clinical,and biochemical data on the day of diagnosis and after the first week of treatment were analyzed using the Mann-Whitney U test,Fisher's exact test,and a multiple logistic regression analysis.RESULTS:The study included 113 patients(87 men and 26 women) with a mean age of 49.84 years.Fiftytwo patients survived,and 61 patients died.Liver failure(85.2%),sepsis(34.4%),and multiple organ failure(39.3%) were the main causes of death.Multivariate analyses showed that Acute Physiology and Chronic Health Evaluation(APACHE) Ⅱ scores ≥ 12 [odds ratio(OR) = 7.160,95% CI:2.834-18.092,P 0.001] and positive blood culture(OR = 13.520,95% CI:2.740-66.721,P = 0.001) on the day of diagnosis and model for end-stage liver disease(MELD) scores ≥ 28(OR = 8.182,95% CI:1.884-35.527,P = 0.005) after the first week of treatment were independent predictors of mortality.CONCLUSION:APACHE Ⅱ scores on the day of diagnosis and MELD scores after the first week of anti-HBV therapy are feasible predictors of outcome in ACLFHBV patients.     

Serum Irisin levels as a marker in some phenotypes of PCOS

Study objectives

The aim of the study was to assay the serum levels of Irisin in women with PCOS.

A Quality Model to Select Patients in Cupping Therapy Clinics: A New Tool for Ensuring Safety in Clinical Practice

Cupping therapy is a popular treatment in various countries and regions, including Saudi Arabia. Cupping therapy is regulated in Saudi Arabia by the National Center for Complementary and Alternative Medicine, Ministry of Health. The authors recommend that this quality model to select patients in cupping clinics - version 1 (QMSPCC-1)—be used routinely as part of clinical practice and quality management in cupping clinics. The aim of the quality model is to ensure the safety of patients and to introduce and facilitate quality and auditing processes in cupping therapy clinics. Clinical evaluation of this tool is recommended. Continued development, reevaluation and reassessment of this tool are important.