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161.
S. Claes A. Vogels M. Holvoet K. Devriendt P. Raeymaekers J. J. Cassiman J. P. Fryns 《American journal of medical genetics. Part A》1997,73(4):474-479
Two families with nonspecific X-linked mental retardation (XLMR) are presented. In the first family, MRX49, 5 male patients in 2 generations showed mild to moderate mental retardation. Two-point linkage analysis with 28 polymorphic markers, dispersed over the X-chromosome, yielded a maximal LOD score of 2.107 with markers DXS7107 and DXS8051 at θ = 0.0, localizing the MRX49 gene at Xp22.3-p22.2, between Xpter and marker DXS8022. Multipoint linkage analysis showed negative LOD values over all other regions of the chromosome. In the second family, MRX50, 4 males in 2 generations showed moderate mental retardation. Pairwise linkage analysis with 28 polymorphic markers yielded a LOD score of 2.056 with markers DXS8054, DXS1055, and DXS1204, all at θ = 0.0. Flanking markers were DXS8012 and DXS991, situating the MRX50 gene at Xp11.3-Xp11.21, in the pericentromeric part of the short arm of the X chromosome. Am. J. Med. Genet. 73:474–479, 1997. © 1997 Wiley-Liss, Inc. 相似文献
162.
Jennifer A. Toomey Sunil Shrestha Sarah A. de la Rue Frances Gays John H. Robinson Zosia M. A. Chrzanowska-Lightowlers Colin G. Brooks 《European journal of immunology》1998,28(1):47-56
Using appropriate conditions natural killer (NK) cells can be cultured from the liver and thymus of day 14 fetal mice. These fetal NK cells are phenotypically and functionally indistinguishable from adult NK cells with the exception that they lack measurable expression of all of the Ly49 molecules that can currently be detected with antibodies. Despite this, they preferentially kill tumor cells and blast cells deficient in the expression of major histocompatibility complex class I molecules, although the degree of discrimination is usually weaker than that shown by adult NK cells and varies depending on the particular combination of effector and target cells used. Polymerase chain reaction analysis revealed that although fetal NK cells are severely deficient in the expression of mRNA for Ly49A, B, C, D, G, H, and I they express high levels of Ly49E mRNA, raising the possibility that Ly49E may have an important and special function in the early development of the NK lineage. 相似文献
163.
旋毛虫p49抗原相关抗体的快速检测 总被引:9,自引:2,他引:7
目的 建立旋毛虫病的快速检测技术。方法 基因工程抗原包被有色乳胶颗粒,抗抗体包被磁性颗粒,在抗体存在下形成抗原- 乳胶- 抗体- 抗抗体- 磁性颗粒的复合场,在磁场作用下沉淀下来,从而达到快速检测旋毛虫相关抗体的目的。结果 19 份人工感染鼠血清、5 份人工感染猪血清、3 份旋毛虫病猪血清、4 份病人血清均呈阳性反应,而对照血清均为阴性反应;该方法在鼠感染旋毛虫后第五天可测出IgM 抗体,第九天可测出IgG抗体。结论 本检测技术简便易行,不需专用设备,可望成为一种快速诊断旋毛虫病的有效方法。 相似文献
164.
BackgroundThis study examined the effects of a patient information leaflet on outcomes related to patient satisfaction following knee arthroscopy.MethodsCohort study of patients listed for knee arthroscopy under the care of a single surgeon over a nine-month period (May 2017–January 2018) following the introduction of an information leaflet as an adjunct to the consent process. Outcome data was collected postoperatively through telephone follow-up. Outcome measures included feelings of involvement with decision-making, expectations being met, satisfaction, postoperative pain numerical rating scales and the Forgotten Joint Score-12.ResultsFifty-five patients were consented by the operating surgeon, of which 28 (50.9%) received a leaflet and 27 (49.1%) did not. Patients who received the information leaflet felt more involved in and informed about the decision to have an operation than patients who did not (p = 0.016), however there were no differences in any other outcomes between patients who did and did not receive a leaflet (p > 0.05).ConclusionsThe use of an information leaflet as an adjunct to the preoperative consultation is an effective way of helping patients feel more involved in the surgical decision-making process, however this does not influence overall outcome or satisfaction metrics. 相似文献
165.
Kerstin Herzer Guido Gerken Daniela Kroy Frank Tacke Julius Plewe Dennis Eurich Ulrich Spengler Christian P. Strassburg Martin-Walter Welker Sven Pischke Martina Sterneck Arianeb Mehrabi Karl Heinz Weiss Adam Herber Thomas Berg Tim Zimmermann Peter R. Galle Hauke Heinzow Heiner Wedemeyer 《Journal of hepatology》2018,68(4):982-984
166.
旋毛虫病p49抗原相关抗体的ELISA检测 总被引:5,自引:0,他引:5
目的 以纯化的融合蛋白p49/GST为抗原建立ELISA检测方法。方法 对一批试验血清进行间接ELISA检测。结果 19份工人感染鼠血清、5份人工感染猪血清、4份病人血清呈IgG抗体阳性,21份人工感染鼠血清呈IgM抗体阳性,而正常对照血清及300份屠宰场待检猪血清均呈阴性反应,其结果与常规压片法结果相符。结论 融合蛋白p49/GST对于研制旋毛虫病的诊断抗原具有潜在应用价值。 相似文献
167.
168.
K Bender S Bissbort A Klein G Mauff A Mayerová M Nagel A Schilling T F Wienker 《Genetic epidemiology》1987,4(1):43-49
Linkage relations of the F13B gene with 38 marker genes are analyzed, which, along with the data of earlier reports on the same subject, brings the number of comparisons to a total of 49. Practically all the lod scores are totally negative. This will mean that the F13B gene can hardly be located on the chromosomes/chromosome arms 1p, 2p, 4q, 6p, 14p, 15p, 20q, 21p, 22 and also not on longer segments of 3q, 6q, 7q, 9p, 9q, 11q, 13q, 14q, 16p, and 16q. 相似文献
169.
对近红外光谱大脑拓扑图技术的成像原理进行了探讨,并对大鼠大脑光敏剂诱导梗塞模型的皮层缺血部位进行定位成像。分别用NIRS拓扑仪、磁共振成像和解剖样本染色,对10只SD雄性大鼠大脑皮层缺血部位进行成像。结果表明:NIRS拓扑图所显示的皮层缺血面积与磁共振图象及解剖样本显示的皮层缺血面积的相关系数分别为0.87(p<0.05)和0.81(p<0.01)。 相似文献
170.
E. Massa E. Michailidou S. Papadopoulos D. Agapakis I. Kotsamidi D. Xarisopoulos E. Iosifidis M. Daoudaki D. Philis G. Imvrios E. Vagdatli D. Vasilakos V. Papanikolaou I. Fouzas E. Mouloudi 《Transplantation proceedings》2019,51(2):457-460