Clinical impact of integrated PET/CT on the management of suspected cervical cancer recurrence

OBJECTIVES: To assess the value and clinical impact of integrated PET/CT using (18)F-FDG in the diagnosis and management of women with suspected cervical cancer recurrence. METHODS: Fifty-two patients with cervical cancer with suspected recurrence because of clinical, cytological, biochemical and radiological findings were retrospectively evaluated. A final diagnosis of recurrence was confirmed by histologic tissue biopsy or by further clinical or radiological evidence. The clinical impact of information provided by PET/CT on patient management was assessed on the basis of clinical follow-up data concerning further diagnostic or therapeutic approach. RESULTS: Twenty-eight of 32 positive PET/CT scans (87.5%) were proven to have recurrent disease. Seventeen of 20 negative PET/CT scans (85.0%) had no evidence of disease. The sensitivity, specificity, and accuracy of PET/CT for detecting recurrence were 90.3%, 81.0%, and 86.5% respectively. PET/CT changed the management of 12 patients (23.1%) by changing treatment plan (5 patients), by initiating unplanned treatment strategy (4 patients), or by obviating the need for planned diagnostic procedures (3 patients). Median duration after performing PET/CT and last follow-up was 12 (range: 6-27) months, and the 2-year disease-free survival rate of patients with negative PET/CT scan for recurrence was significantly better than that of patients with positive PET/CT (85.0% vs. 10.9%, P=0002). CONCLUSIONS: In patients with a suspected recurrence of cervical cancer, integrated PET/CT using (18)F-FDG provides good anatomic and functional localization of suspicious lesions, and the better diagnostic interpretation has an impact not only on clinical management and treatment planning of patients, but also on disease-free survival.     

CBCT/CT与普通X线片在上颌前牙区埋伏多生牙定位的比较

目的探讨锥形束CT(CBCT)/CT与普通X线片在上颌前牙区埋伏多生牙定位检查的应用价值。方法结合临床病例,对上颌前牙区完全埋伏多生牙采用CBCT/CT与多种普通X线片定位方法进行比较和分析。结果普通X线片对埋伏多生牙的定位有一定帮助,视差定位法是比较经济和实用的定位方法。CBCT/CT检查能准确展示多生牙的三维结构,并进行相应的测量与辅助手术设计,与普通X线片比具有显著优势。结论上颌前牙区埋伏多生牙可根据医疗条件选择适合的定位检查方法,而CBCT检查将是发展的趋势。     

Effects of tooth rotation on neighboring teeth and periodontal tissues

In the present experiment,we investigate the effects of orthodontic tooth rotation onneighboring teeth and periodontal tissues.The second maxillary incisors of 16 randomly selecteddogs were subjected to rotation at a magnitude of 100 grams and a moment of 550 g·mm in a du-ration of 3 to 56 days.Then sections were prepared for histological examination.The findings re-vealed that,due to tooth rotation,neighboring teeth were drifted and rotated(82%),and therewere disarrangement and hyalinization of the periodontal ligament(88%),remodeling of the pe-riodontium(86%)and root resorption(32%)were also observed.These results demonstratethat tooth rotation may exert marked effects on neighboring teeth and periodontal tissues,whichmay be of important clinical significance.     

A study of the rotation rate of single-rooted teeth in dogs

Sixteen one-year-old dogs were used in our experiment.We rotated the maxillary secondincisors of the dogs,applying a force of 100g and a moment of 550g·mm.The duration of theexperiment varied from 72h to 8 weeks.Activation was performed once every 2 weeks and the impressions were taken in order to measure the angles of rotation.The results of our experiment showthat the rotation rate of single-rooted tooth in dogs is 3.04/week.The graph shows the form ofgradual stairs.This paper introduces a new specialized experimental apparatus for tooth rotation.The angles of rotation are measured geometrically.     

牙种植修复牙列缺损185例远期效果临床观察

目的探讨牙种植修复对牙列缺损的远期效果。方法回顾性分析我院2005年6月-2007年6月接受牙种植修复治疗的185例（339枚）牙列缺损患者临床资料,分析植入后0．5、1、3、5年植入成功率及牙槽骨吸收和周围软组织情况。结果半年内成功336枚,成功率为99．1％;负载1、3、5年后,累积成功率分别为99．1％、97．6％、95．0％。结论对牙列缺损患者进行全面评价,选择合适的种植方法和时机,可取得良好的远期修复效果。     

Impact of Guidelines for Antihypertensive Treatment on Clinical Practice

Many Guidelines and Consensus Statements were published in 1993 and 1994. The pressure to produce these guidelines comes from clinicians faced with rapid change, from a wish to provide an independent authoritative view rather than rely on commercial promotion of particular treatments, and from governments seeking assistance with the allocation of scarce resources.

Evaluation of the impact that guidelines exert on clinical practice is notoriously difficult, but has been attempted using the self-report questionnaire, or the more reliable but expensive analysis of actual practice data, before and after publication of the guidelines.