首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   2287篇
  免费   113篇
  国内免费   14篇
耳鼻咽喉   4篇
儿科学   3篇
妇产科学   5篇
基础医学   164篇
口腔科学   793篇
临床医学   180篇
内科学   591篇
皮肤病学   7篇
神经病学   102篇
特种医学   140篇
外科学   121篇
综合类   143篇
预防医学   53篇
眼科学   2篇
药学   71篇
中国医学   18篇
肿瘤学   17篇
  2024年   4篇
  2023年   53篇
  2022年   74篇
  2021年   104篇
  2020年   88篇
  2019年   207篇
  2018年   225篇
  2017年   95篇
  2016年   80篇
  2015年   65篇
  2014年   204篇
  2013年   145篇
  2012年   94篇
  2011年   136篇
  2010年   81篇
  2009年   101篇
  2008年   96篇
  2007年   147篇
  2006年   78篇
  2005年   78篇
  2004年   69篇
  2003年   41篇
  2002年   18篇
  2001年   24篇
  2000年   20篇
  1999年   19篇
  1998年   17篇
  1997年   14篇
  1996年   9篇
  1995年   4篇
  1994年   4篇
  1993年   3篇
  1992年   2篇
  1991年   2篇
  1990年   3篇
  1989年   1篇
  1986年   1篇
  1985年   3篇
  1984年   1篇
  1983年   2篇
  1982年   1篇
  1977年   1篇
排序方式: 共有2414条查询结果,搜索用时 21 毫秒
51.

Background

Intravascular volume expansion plays a major role in the prevention of contrast-induced acute kidney injury (CI-AKI). Recommended standard amounts of fluid infusion before procedures do not produce homogeneous responses in subjects with different initial hydration status.

Objectives

The goal of this study was to compare the effect of standard and double intravenous (IV) infusion volumes in patients with low body fluid level, assessed by using bioimpedance vector analysis (BIVA), on the incidence of CI-AKI after elective coronary angiographic procedures.

Methods

A total of 303 patients with low BIVA level on admission were randomized to receive standard volume saline (1 ml/kg/h for 12 h before and after the procedure) or double volume saline (2 ml/kg/h). Patients (n = 715) with an optimal BIVA level received standard volume saline and were included in a prospective registry. The saline infusion was halved in all patients with an ejection fraction <40%. BIVA was repeated immediately before the angiographic procedure in all patients. CI-AKI was defined as an increase in levels of cystatin C ≥10% above baseline at 24 h after contrast administration.

Results

The incidence of CI-AKI was significantly lower (11.5% vs. 22.3%; p = 0.015) in patients receiving double volume saline than in those receiving standard volume saline, respectively. Before the angiographic procedure, 50% of the double volume patients achieved the optimal BIVA level compared with only 27.7% in the standard group (p = 0.0001). The findings were consistent in all the pre-specified subgroups excluding patients with a left ventricular ejection fraction <40% (p for interaction = 0.01).

Conclusions

Evaluation of BIVA levels on admission in patients with stable coronary artery disease allows adjustment of intravascular volume expansion, resulting in lower CI-AKI occurrence after angiographic procedures. (Personalized Versus Standard Hydration for Prevention of CI-AKI: A Randomized Trial With Bioimpedance Analysis; NCT02225431)  相似文献   
52.
53.
One problem that may arise in full‐coverage restorations is clinical crown fracture. Fracture of an endodontically treated and crowned tooth in the esthetic zone may be embarrassing to both the patient and clinician. If a completely sound margin and at least 2 mm of coronal structure remain, a fractured tooth may possibly be retreated by a repair. Several methods have been introduced to reproduce the original contour of the tooth for retrofitting an existing crown. If an existing crown is used as a template, excessive core material may remain over the margin, as loading the proper amount of core material is difficult, and making vent holes on the existing crown is not feasible. This article presents a repair technique to reuse an existing crown with computer‐aided design and computer‐aided manufacturing (CAD/CAM) technology. By using a milled poly(methylmethacrylate) matrix, the mentioned limitations are eliminated, and the original contour of the tooth can be effectively restored with minimal intervention. As an existing crown is reused, the issues of additional time and cost for repreparation, reimpression, and new crown are eliminated.  相似文献   
54.
55.
56.
57.

Objectives

The aim of this study was to determine, by using a spectrophotometer device, the colour stainability of two indirect CAD/CAM processed composites in comparison with two conventionally laboratory-processed composites after being immersed 4 weeks in staining solutions such as coffee, black tea and red wine, using distilled water as control group.

Methods

Two indirect CAD/CAM composites (Lava Ultimate and Paradigm MZ100) and two conventionally laboratory-processed composites (SR Adoro and Premise Indirect) of shade A2 were selected (160 disc samples). Colour stainability was measured after 4 weeks of immersion in three staining solutions (black tea, coffee, red wine) and distilled water. Specimen's colour was measured each week by means of a spectrophotometer (CIE L*a*b* system). Statistical analysis was carried out performing repeated ANOVA measurements and Tukey's HSD test to evaluate differences in ΔE00 measurements between groups; the interactions among composites, staining solutions and time duration were also evaluated.

Results

All materials showed significant discoloration (p < 0.01) when compared to control group. The highest ΔE00 observed was with red wine, whereas black tea showed the lowest one. Indirect laboratory-processed resin composites showed the highest colour stability compared with CAD/CAM resin blocks.

Conclusions

CAD/CAM processed composites immersed in staining solutions showed lower colour stability when compared to conventionally laboratory-processed resin composites.

Clinical significance

The demand for CAD/CAM restorations has been increasing; however, colour stainability for such material has been insufficiently studied. Moreover, this has not been performed comparing CAD/CAM processed composites versus laboratory-processed indirect composites by immersing in staining solutions for long immersion periods.  相似文献   
58.
ObjectivesTo compare relapse and failure rates of computer-aided design/computer-aided manufacturing (CAD/CAM) and standard fixed retainers.Materials and MethodsThis single-center, single-blinded, prospective randomized clinical trial included 46 patients who completed active orthodontic treatment and complied with retention visits. The patients were randomly assigned to three groups: CAD/CAM group with multistranded stainless steel wires (CAD/CAM, n = 16), Lab group with the same multistranded wires (lab, n = 16), and control group with stainless steel Ortho-FlexTech wires (traditional, n = 14). Intraoral scans were obtained at placement of fixed retainers (T1), 3-month visit (T2), and 6-month visit (T3) and measured for intercanine width and Little''s Irregularity Index. Failures were recorded.ResultsThe CAD/CAM group experienced less intercanine width decrease than the traditional group at 3 months (mean difference, 0.83 ± 0.16 mm; 95% confidence interval [CI], 0.44–1.22; P < .001) and 6 months (mean difference, 1.23 ± 0.40 mm; 95% CI, 0.19–2.27; P < .05). The CAD/CAM group experienced less increase in Little''s Irregularity Index compared with the lab group within 3 months (mean difference, 0.81 ± 0.27 mm; 95% CI, 0.12–1.49; P < .05). Failures from greatest to least were experienced by the lab group (43.8%), the CAD/CAM group (25%), and the traditional group (14.3%).ConclusionsWithin 6 months of bonding fixed retainers, CAD/CAM fixed retainers showed less relapse than lab-based and traditional chairside retainers and less failures than lab-based retainers.  相似文献   
59.
60.
目的 探讨不同粘接剂间隙对CAD/CAM嵌体氧化锆粘接强度的影响.方法 选取因正畸需要拔除的第一前磨牙30颗作为本研究对象,依照设置粘接剂间隙参数不同分为10μm(A组)、30μm(B组)、50μm(C组)制作嵌体;用轻体型硅橡胶复制边缘间隙,体视显微镜测量边缘间隙的厚度,使用SPSS13.0软件包对数据进行分析.结果 所有瓷嵌体均可顺利就位,测量数据均小于120μm,A组肩台间隙明显低于B组及C组(P<0.05),且B组轴面显著低于C组(P<0.05).结论 在粘接间隙设定为10~50μm时,CEREC制作瓷嵌体均可取得满意效果.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号