Cranial Tumor Surgical Outcomes at a High-Volume Academic Referral Center

Objective

To determine adverse event rates for adult cranial neuro-oncologic surgeries performed at a high-volume quaternary academic center and assess the impact of resident participation on perioperative complication rates.

Feasibility of simultaneous Tc99m sestamibi and 2D-echo cardiac imaging during dobutamine pharmacologic stress

Feasibility of simultaneous 2D-Echo and SPECT Tc99m Sestamibi imaging during dobutamine infusion was evaluated in a female population with suspected coronary artery disease and scheduled for diagnostic coronary angiography. A total of 49 consecutive subjects were studied. Patients under continuous ECG and 2D-Echo monitoring underwent standard dobutamine infusion at increasing doses to a diagnostic end-point. Tc99m Sestamibi was administered at the peak of the dobutamine effect. With this approach, 35 patients were identified correctly by 2D-Echo (Sensitivity = 60.1%; Specificity = 83.3%; Agreement = 71.4%; k = 0.43). Perfusion imaging with Tc99m Sestamibi resulted in correctly identifying 41 patients (Sensitivity = 83%; Specificity = 84%; Agreement = 83.6%; k=0.67). Combining information obtained from the two tests resulted in increased specificity (92%) and decreased sensitivity (64%). Simultaneous assessment of perfusion and function with Tc99m Sestamibi and 2D-Echo imaging during dobutamine administration is easily performed without added risk or discomfort to the patient. Tc99m Sestamibi appeared to be slightly superior to 2D-Echo for the detection of CAD in this population, but the difference does not reach conventional statistical significance. The combined use of the two independent tests did not substantially improve the diagnostic accuracy of each method.     

Quantitative Myocardial Perfusion Imaging Versus Visual Analysis in Diagnosing Myocardial Ischemia: A CE-MARC Substudy

Objectives

This study sought to compare the diagnostic accuracy of visual and quantitative analyses of myocardial perfusion cardiovascular magnetic resonance against a reference standard of quantitative coronary angiography.

钛基台支持的CAD/CAM全瓷单冠不同载荷位置的三维有限元应力分析

目的分析钛基台支持的CAD/CAM全瓷单冠在载荷位置不同时全冠的应力情况,为种植上部结构的临床设计提供理论参考。方法建立钛基台以及粘接固位的下颌第二前磨牙牙冠的三维有限元模型,在基台上方偏颊侧(a)、基台正上方(b)、基台上方偏舌侧(c)的牙冠■面3个不同部位分别施加300N的轴向静载荷,计算分析全冠的应力情况。结果对于玻璃陶瓷全冠,当载荷作用于位置a时,最大拉应力在舌侧颈缘处,约为13MPa;最大压应力位于颊侧颈缘处,约为-45MPa。载荷作用于位置b时,最大拉应力在与基台顶部中心区域接触处的牙冠组织面,约为20MPa。载荷作用于位置c时,最大拉应力在牙冠颊侧颈缘处约为15MPa;舌侧颈缘处最大压应力值为-40MPa。氧化锆全冠在三种载荷类型时的应力场分布与玻璃陶瓷全冠类似,应力值大小不同。结论钛基台支持的CAD/CAM全瓷单冠,当载荷作用于位置a时,牙冠颊侧颈缘应增加强度以防止折裂,牙冠舌侧颈缘处应防止脱粘接;载荷作用于位置b时,基台上方牙冠■面需要增加强度;载荷作用于位置c时,牙冠颊侧颈缘处易发生脱粘接,舌侧颈缘处容易折裂。     

Viscoelastic stability of pre-cured resin-composite CAD/CAM structures

ObjectivesTo study the effect of water storage (3 months) on the creep deformation and recovery of CAD/CAM composite materials to determine their viscoelastic stability.Materials and methodsFive CAD/CAM composite blocks, with increasing filler loading, and one polymer-infiltrated ceramic network (PICN) were studied. Six specimens of each material were separated into two groups (n=3) according to their storage conditions (24 h dry storage at 23°C versus 3 months storage in 37°C distilled water). A constant static compressive stress of 20 MPa was applied on each specimen via a loading pin for 2 h followed by unloading and monitoring strain recovery for a further period of 2 h. The maximum creep-strain (%) and permanent set (%) were recorded. Data were analysed via two-way ANOVA followed by one-way ANOVA and Bonferroni post hoc tests (<0.05) for comparisons between the materials. Homogeneity of variance was calculated via Levene’s statistics.ResultsThe maximum creep strain after 24 h dry ranged from 0.45% to 1.09% and increased after 3-month storage in distilled water to between 0.71% and 1.85%. The permanent set after 24 h dry storage ranged from 0.033% to 0.15% and increased after 3-month water storage to between 0.087% and 0.18%. The maximum creep strain also reduced with increasing filler loading.SignificanceThe PICN material exhibited superior dimensional stability to all of the pre-cured resin composite blocks in both storage conditions with deformation being predominantly elastic rather than viscoelastic. Notwithstanding, two of the resin-matrix composite blocks approached the PICN performance, when dry, but less so after water storage.