首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   214篇
  免费   5篇
  国内免费   1篇
耳鼻咽喉   1篇
儿科学   8篇
妇产科学   2篇
基础医学   23篇
口腔科学   7篇
临床医学   13篇
内科学   31篇
皮肤病学   4篇
神经病学   7篇
特种医学   6篇
外科学   9篇
综合类   30篇
预防医学   16篇
眼科学   4篇
药学   27篇
中国医学   20篇
肿瘤学   12篇
  2023年   1篇
  2022年   4篇
  2021年   3篇
  2020年   1篇
  2019年   5篇
  2018年   17篇
  2017年   7篇
  2016年   3篇
  2015年   2篇
  2014年   15篇
  2013年   21篇
  2012年   13篇
  2011年   16篇
  2010年   12篇
  2009年   7篇
  2008年   14篇
  2007年   9篇
  2006年   11篇
  2005年   7篇
  2004年   5篇
  2003年   7篇
  2002年   10篇
  2000年   3篇
  1999年   1篇
  1998年   1篇
  1997年   6篇
  1996年   2篇
  1995年   1篇
  1994年   2篇
  1992年   2篇
  1988年   1篇
  1986年   1篇
  1985年   1篇
  1984年   2篇
  1983年   2篇
  1981年   3篇
  1976年   1篇
  1968年   1篇
排序方式: 共有220条查询结果,搜索用时 15 毫秒
51.
The antagonistic analog of LHRH, NAc-D-p-C1-Phe1,2, D-Trp3, D-Phe6, D-Ala10-LHRH was administered intramuscularly in a dose of 2 mg to ten normally ovulating women on day 12 of the menstrual cycle. Ovulation was inhibited in six patients, and two more presented an insufficient corpus luteum. No pregnancies were recorded in this series. In those patients who did not ovulate, it was demonstrated that the LHRH analog abolished the midcycle surge of both LH and FSH. Luteolysis evidenced by the rapid decline in progesterone levels was present in 2 cases. Bleeding pattern showed a tendency to delayed menses. The morphological findings in endometrial biopsies of 6 women exhibited mild proliferation. Further research along these lines is necessary for appraisal of this approach to birth control.  相似文献   
52.
王旭  洪兵  孙斯凡  徐奚如  金晶 《中医杂志》2011,52(16):1402-1405
目的探讨糖足洗液对链脲佐菌素(STZ)诱导的糖尿病小鼠皮肤溃疡的疗效及机理。方法昆明种小鼠50只,随机抽取10只为正常对照组,其余小鼠在禁食12h后均按150mg/kg腹腔注射STZ造模,并随机分为模型对照组、单用胰岛素组、糖足洗液组、金黄散对照组,每组10只。5组小鼠均在背部单侧制造直径约8mm的皮肤溃疡模型。除正常对照组和模型对照组外,其余3组均注射胰岛素,其中2组分别予糖足洗液及金黄散湿敷。动态观测各组小鼠体重、创面大小、空腹血糖(FBG)等指标。连续用药30d后禁食8h,测定C反应蛋白(CRP)、白介素6(IL-6)和肿瘤坏死因子-α(TNF-α)等指标。结果糖足洗液组糖尿病小鼠溃疡时间早于模型对照组,差异有统计学意义(P<0.01),FBG、CRP、IL-6、TNF-α均低于模型对照组,体重高于模型对照组,差异均有统计学意义(P<0.05或P<0.01)。结论在胰岛素有效控制血糖的前提下,应用糖足洗液能够缩短溃疡愈合时间、促进肉芽组织生长、促进创面愈合,其机制与降低炎症细胞因子水平有关。  相似文献   
53.

Ethnopharmacological importance

Many Bauhinia species, including those indigenous to South Africa, are used in traditional medicine across the world for treating ailments such as gastrointestinal tract (GIT) disorders, diabetes, infectious diseases and inflammation.

Aims

Several relevant aspects of different fractions of leaf extracts of Bauhinia bowkeri (BAB), Bauhinia galpinii (BAG), Bauhinia petersiana (BAP), and Bauhinia variegata (BAV) used in South African traditional medicine to alleviate diarrhoea related symptoms were evaluated.

Materials and Methods

The antioxidative activities of the extracts were determined using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH), 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS+) radical scavenging and ferric reducing antioxidant power (FRAP) methods. In vitro antimicrobial activities of the extracts were determined against bacterial strains (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Enterococcus faecalis) and clinical isolates of the opportunistic fungal strains (Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans) using a serial dilution microplate method. The polyphenolic contents were quantified using standard methods, and anti-inflammatory activities of the crude extracts were determined using the cyclooxygenase and soybean 15-lipoxygenase enzyme inhibitory assays. The safety of the extracts was evaluated by determining the cytotoxicity against Vero cell lines.

Results

The acidified 70% acetone crude extract and their fractions had good antiradical potency against the DPPH and ABTS radicals. The methanol soluble portions of the butanol fractions were more potent (EC50 ranges from 0.64±0.05 to 1.51±0.07 and 0.88±0.18 to 1.49±0.09 μg/ml against DPPH and ABTS radical respectively) compared to the standard, trolox and ascorbic acid (EC50 ranges from 1.47±0.24 to 1.70±0.27 μg/ml) for both DPPH and ABTS. The crude extracts contained variable quantities of phenolic content. The crude extracts and their fractions had weak to good antimicrobial activities, inhibiting the growth of the organisms at concentrations ranging from 39 to 2500 μg/ml. The BAG crude extract and its fractions were the most active against the fungi (MICs ranging from 39 to 625 μg/ml) while the BAB extract and its fractions were the least active with the MICs ranging between 39 and 2500 μg/ml. Aspergillus fumigatus was the least susceptible fungus while Cryptococcus neoformans was the most susceptible.The phenolic-rich crude extracts of BAB, BAG, and BAP had moderate to good dose-dependent cyclooxygenase-1 enzyme inhibitory activity with inhibitions between 22.8% and 71.4%. The extracts were however, inactive against cyclooxygenase-2. The extracts had some level of cytotoxicity towards Vero cell lines, reducing cell viability to less than 10% at concentrations more than 50 μg/ml.

Conclusion

The biological activities observed in Bauhinia species provide a scientific basis for the use of the plants in traditional medicines to treat diseases with multi-factorial pathogenesis such as diarrhoea, with each aspect of activity contributing to the ultimate therapeutic benefit of the plants. However, the use of the phenolic-rich extracts of these plants to treat diarrhoea or any other ailments in traditional medicine needs to be monitored closely because of potential toxic effects and selective inhibition of COX-1 with the associated GIT injury.  相似文献   
54.
目的探讨小鼠视网膜方向选择性神经节细胞(DSGC)树突野(DF)的发育及其与胆碱能细胞阵列的关系。 方法选用中国科学院生物物理研究所实验动物中心繁殖的清洁级YFP(H)品系的转基因小鼠(种鼠来源于The Jackson实验室)共36只,0~1月龄,雌雄不限。对出生后不同发育时期(P8、P13及成年)的小鼠视网膜中ON/OFF DSGC及OFF DSGC的DF范围内包含的胆碱能细胞的数目采用单因素方差分析进行比较,当差异有统计学意义时,进一步两两比较。 结果ON/OFF DSGC作为经典的方向选择性神经节细胞,其树突具有两层树突结构,分别分布在视网膜内网状层的ON和OFF亚层中,其树突弯曲度和树突分支之间的夹角比较大,分支多向胞体方向返回呈半环状,显著的特点是同一细胞的树突不会发生交叉。P8时,D2亚类神经节细胞(即ON/OFF DSGC)DF范围中分别包含(25.6±4.8)个内核层(INL)的胆碱能无长突细胞和(28.4±5.7)个视网膜神经节细胞(GCL)的胆碱能无长突细胞(n=7);P13时,D2亚类神经节细胞DF范围中分别包含(30.8±9.5)个INL的胆碱能无长突细胞和(35.2±10.4)个GCL的胆碱能无长突细胞(n=10);成年时,D2亚类神经节细胞DF范围中分别包含(33.7±7.4)个INL的胆碱能无长突细胞和(32.1±5.6)个GCL的胆碱能无长突细胞(n=9),三个时期的胆碱能无长突细胞的数目差异均无统计学意义(F=2.16,1.55;P>0.05)。而视网膜中另外一种方向选择性神经节细胞OFF DSGC的DF范围内无长突细胞的数目从P8到P13先增多,然后从P13到成年又减少。P8时,该类细胞DF范围内位于GCL的无长突细胞数目为(20.0±2.5,n=8)个,明显少于P13时的(32.0±7.1,n=6)个;成年时,数目又减少到(23.7±7.5,n=14)个。,三个时期的胆碱能无长突细胞的数目差异均无统计学意义(F=6.19,1.55;P<0.05)。 结论小鼠视网膜ON/OFF DSGC的DF在出生后早期就已经发育成熟,并和胆碱能细胞形成稳定的联系,不再受后期双极细胞及光刺激的影响,而OFF DSGC的DF发育可能包含不同的分子和细胞机制。  相似文献   
55.
目的 初步探讨糖尿病足中医不同证型与下肢动脉彩超的关系.方法 收集糖尿病足病例60例,非糖尿病住院病人45例作为对照组,记录相应下肢动脉彩超结果,并进行初步相关性分析.结果 与非糖尿病组比较,糖尿病足组双下肢动脉内径均较窄,其中股总动脉、腘动脉、胫前动脉、胫后动脉内径差异有统计学意义(P<0.01);分型研究中,气阴两虚瘀阻组各下肢动脉内径最窄,与其他证型组比较差异有统计学意义(P<0.01或P<0.05).结论 糖尿病足中医不同征型与下肢动脉彩超有一定的相关性,糖尿病足表现为各下肢动脉内径变窄,以气阴两虚瘀阻型明显.  相似文献   
56.
目的:观察乌苯美司联合DF方案治疗晚期食管癌的临床疗效及不良反应。方法:将54例晚期食管癌患者随机分为对照组(30例)和观察组(24例),对照组采用DF方案化疗,观察组在DF方案基础上加用乌苯美司片。评价两组患者化疗效果及生活质量,观察不良反应。结果:观察组总有效率为45.8%,对照组为40.0%,差异无统计学意义(P>0.05)。观察组进展率为16.7%,对照组为43.3%,差异有统计学意义(P<0.05)。观察组生活质量评价优于对照组(P<0.05),血液系统不良反应发生率低于对照组(P<0.05)。结论:乌苯美司联合DF方案能改善晚期食管癌化疗效果及生活质量,并对化疗有一定的减毒作用。  相似文献   
57.
DF和DPE方案治疗晚期食管癌78例疗效分析   总被引:1,自引:0,他引:1  
1995年5月至1995年8月我们采用DF和DPE方案,分别治疗中晚期食管癌42例和36例。DF组的缓解率为61.9%(26/42),其中完全缓解16.7%;DPE组的缓解率为47.2%(17/36),完全缓解5.6%。两组缓解率差异无显著性(P>0.05)。DF的恶心呕吐为85.7%,肾脏毒性9.5%,DPE方案的恶心呕吐为80.6%,肾毒性5.5%。  相似文献   
58.
Dendritic cell specific intercellular adhesion molecule 3 grabbing non-integrin, coded by the CD209 gene, acts as an entry receptor for dengue virus. Polymorphisms in the promoter region of CD209 gene (rs735239, rs4804803, rs2287886) were investigated in 112 hospitalized cases of dengue (DEN) and 104 healthy controls to find out whether they are associated with dengue in a Western Indian population. Results revealed a significantly higher frequency of ‘G’ allele and ‘G/G’ genotype of rs2287886 and A-A-G haplotype of CD209 gene in DEN compared to healthy controls [For ‘G/G’ genotype, P = 0.0072, Odds ratio (OR) 2.43; For A-A-G haplotype, P = 0.0033, OR 2]. The frequency of A/A genotype of rs735239 was higher in DEN cases with thrombocytopenia compared to cases without thrombocytopenia (P = 0.026). The results suggest that rs2287886 G/G genotype of CD209 gene is associated with development of dengue requiring hospitalization while A/A genotype of rs735239 is associated with thrombocytopenia in dengue cases.  相似文献   
59.
Our hospital is a referral centre for Jehovah’s Witnesses (JW) patients, who as a matter of religious belief refuse transfusions of blood/blood components. We have treated JW patients with dengue fever (DF) and thrombocytopenia without platelet transfusion, without any mortality or major morbidities. We retrospectively compared the duration needed for platelet recovery and duration of hospitalization of DF with thrombocytopenia in those treated with prophylactic platelet transfusion and JW patients who were managed without these. Among JW patients, platelet counts recovered to >50,000 in 2.57 days (Mean) as compared to those who received prophylactic platelet transfusion, who recovered in 4.43 days (P value < 0.0001). They also had significantly less number of days of hospitalization (3.68 days vs 5.13 days, P value < 0.0001). These differences persisted even when a subgroup analysis of patients who had nadir platelet count less than 10,000 were done. Most importantly, none of the patients in either group suffered any significant morbidity or mortality. Prophylactic platelet transfusion in clinically stable DF patients was associated with significant delay in platelet recovery and increased duration of hospitalization, even though was not harmful in terms of morbidity or mortality. Though number of subjects involved in the study was small, this brief report further adds to the current evidence that prophylactic platelet transfusion in clinically stable DF patients with a platelet count more than 10,000/cmm is not indicated.  相似文献   
60.
目的 观察自体富血小板凝胶治疗糖尿病足溃疡(DFU)的疗效. 方法 72例DFU患者按照数字随机法分为两组.治疗组采用自体富血小板凝胶外敷;对照组采用常规疗法.比较两组DFU治愈率、好转率及愈合时间. 结果 两组间年龄、糖尿病病程、FPG、FIns、HbA1c、稳态模型评估胰岛素抵抗指数(HOMA-IR)、BMI、TG、TC、LDL-C、HDL-C、溃疡面积及溃疡体积比较差异均无统计学意义(P>0.05).两组Wagner Ⅰ级DFU治疗的疗效比较差异均无统计学意义(P>0.05).在WagnerⅡ、Ⅲ级DFU病例中,治疗组治愈率(66.7%、70.0%)、总有效率(94.4%、90.0%)均高于对照组(治愈率:26.3%、57.9%;总有效率:10.0%、30.0%)(P<0.05);治疗组Wagner Ⅰ~Ⅲ级DFU愈合时间均短于对照组[WagnerⅠ级:(14.75±1.82) vs (22.00±1.63)d;WagnerⅡ级:(27.12±2.15) vs (34.93±1.44)d;WagnerⅢ级:(41.89±3.22) vs (53.83±1.17)d] (P<0.05). 结论 自体富血小板凝胶可能具有促进DFU愈合的作用.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号