The bilateral conchal cartilage graft: A new technique in augmentation rhinoplasty

The most common procedures to reconstruct a severe saddle-nose deformity are autogenous costal cartilage, iliac bone grafting, or Silastic implants. Each of them has its specific disadvantages. As an alternative solution, an autogenous bilateral conchal graft in sand-wich technique is described. A 3-layer graft for the dorsum and a 2-layer graft to support the depressed columellar-tip area grants a more natural and elastic reconstruction of the nasal framework. The conchal grafts are taken by an incision made on the preauricular surface of the ear. How to plane the curved grafts by meticulous cross-hatching and to immobilize them in the recipient area by transcutaneous suturing is demonstrated.Presented at the VIII International Congress of Plastic and Reconstructive Surgery, Montreal, Canada, June, 1983     

Use of biologics in rotator cuff disorders: Current concept review

Poor tendon to bone healing following rotator cuff repair has led to the continued interest and investigation into biological augmentation. The biology of tendinopathy is not fully understood and consequently the availability of disease modifying therapeutic targets is limited. A ceiling of benefit has been reached by mechanical optimisation of rotator cuff repair and thus, in order to improve healing rates, a biological solution is required. This review focuses on the strategies to biologically augment rotator cuff disorders with an emphasis on rotator cuff repair. Leucocyte rich platelet rich plasma has been shown to improve healing rates without clinically relevant improvements in outcome scores. Similarly, improved healing rates have also been reported with bone marrow stimulation and in long-term follow-up with bone marrow concentrate. Extracellular matrix (ECM) and synthetic scaffolds can increase healing through mechanical and or biological augmentation. A potential third category of scaffold is bio-inductive and has no mechanical support. Studies involving various scaffolds have shown promising results for augmentation of large to massive tears and is likely to be most beneficial when tendon quality is poor, however level I evidence is limited.     

The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP-mediated cell death.

Here we analyze limb development after the conditional inactivation of Fgf8 from the epiblast, using the previously described MORE (Mox2Cre) line. This line drives variable mosaic recombination of a floxed Fgf8 allele, resulting in a small proportion of AER cells that maintain Fgf8 expression. The phenotype of Mox2Cre;Fgf8 limbs is most similar to that of Msx2Cre;Fgf8 forelimbs, indicating that a small but durable expression of FGF8 is equivalent to an early normal, but transitory, expression. This functional equivalence likely relies on the subsequent Fgf4 upregulation that buffers the differences in the pattern of Fgf8 expression between the two conditional mutants. The molecular analysis of Mox2Cre;Fgf8 limbs shows that, despite Fgf4 upregulation, they develop under reduced FGF signaling. These limbs also exhibit an abnormal area of cell death at the anterior forelimb autopod, overlapping with an ectopic domain of Bmp7 expression, which can explain the abnormal morphogenesis of the anterior autopod.     

正畸力作用下上颌尖牙生物组织应力的三维有限元分析

建立了包括牙齿、牙周膜、牙髓、牙槽骨的上颌尖牙三维有限元模型 ,对不同加力方式下牙周组织的应力分布进行对比研究。目的是用较为先进和准确的双螺旋 CT法建立尖牙的三维有限元应力分析模型 ,为正畸治疗提供更为准确的数据并为模拟尖牙在正畸力作用下移动过程的模拟初态建立更为精确的模型。     

Safety of injectable autologous human fibroblasts

Autologous dermal fibroblasts after propagation in cell culture were used for face soft tissue augmentation. Twenty patients aged 37–61 years with facial rhytides and atrophic scars were treated with autologous fibroblasts from cell culture. Significant sustained clinical improvement was observed. Cells of early passages (4, 5, 6) were used for injection. The study showed that cultured fibroblasts were functionally active and produced large quantities of type I collagen.In vitro studies of scar formation potency of injectable fibroblasts showed that these cells possessed normal collagen gel contraction capacity.In vivo experiments showed that cultured fibroblasts exhibited no oncogenic properties and induced no tumors in nude mice. Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 203–206, August, 2000     

Blood styrene concentrations in a “normal” population and in exposed workers 16 hours after the end of the workshift

Summary Blood styrene was measured by a gas chromatography-mass spectrometry method in 81 normal people and in 76 workers exposed to styrene. In the normal subjects, styrene was also tested in alveolar and environmental air. Styrene was found in nearly all (95%) blood samples. Average styrene levels in the normal subjects were 221 ng/1 in blood (Cb), 3 ng/1 in alveolar air (Ca) and 6 ng/1 in environmental air (Ci). Styrene levels did not differ significantly between smokers and non-smokers, 95% of values being below 512 ng/1 in Cb, 7 ng/1 in Ca and 15 ng/l in Ci. In workers with an average exposure to styrene of 204 g/l, at the end of the workshift, mean blood styrene concentration was 1211 g/l. In blood samples collected at the end of the Thursday shift, styrene levels were significantly higher (1590 g/1) than those found at the end of the Monday shift (1068 g/l. A similar difference was found in samples taken the morning after exposure (60 and 119 g/l, respectively). Significant correlations between blood and environmental styrene were found both at the end of the shift and the morning after exposure (r=0.61 and 0.41, respectively). In workers occupationally exposed to styrene, 16 h after the end of the workshift, blood styrene (94 g/l) was significantly higher than that found in the normal subjects (0.22 g/l). The half-life of blood styrene was 3.9 h.     

基于改进TransUnet网络的血管内超声图像边界提取方法研究

血管内超声(IVUS)图像是观测血管内部结构的首选影像学手段,基于IVUS图像的内膜和中外膜边界的提取是实现冠脉粥样硬化精准诊断的前提和关键。针对IVUS图像结构复杂、对比度低、边界提取困难等问题,本研究提出一种基于改进TransUnet网络的分割方法。首先,针对IVUS图像边界提取难点,对边血管、血管分叉、导丝伪像、阴影等4种图像结构进行建模,并基于建模结果予以定向数据增强;而后,结合IVUS图像的环状结构分布特点,在TransUnet网络中提出了Polar-bias归纳偏置的策略,并对IVUS图像进行像素级的分类;最后,基于分类结果优化GVF snake模型的外力场,进而提取IVUS图像的内膜和中外膜边界。采用国际标准IVUS图像数据集(两组不同中心频率,共512幅图像)对算法进行评测,引入JMard距离(JM),Hausdorff距离(HD)和面积差异百分比(PAD)等3个评测指标,在数据集A中JM为0.87, HD为0.87, PAD为0.18,数据集B中JM为0.91, HD为0.25, PAD为0.08。实验结果表明,所提出的算法在两组数据集的内膜及中外膜提取问题中的表现均...