微管微创人工流产术终止妊娠的临床观察

目的观察微管微创人工流产术终止妊娠的疗效。方法将本院2010年1月至2013年9月收治的行人工流产术的孕妇120例根据人工流产方式不同分为传统手术组和微管微创手术组,每组各60例。微管微创手术组孕妇行微管微创人工流产术,传统手术组孕妇行传统负压吸宫术。观察两组孕妇术后疼痛情况、手术时间、术中出血量、疗效及阴道流血时间。结果微管微创手术组孕妇1级疼痛者多于传统手术组,2、3级疼痛者较传统手术组少,手术时间、术中出血量均明显少于传统手术组,差异均具有显著性(P<0.05)。两组孕妇均完全流产,微管微创手术组孕妇术后阴道出血时间为(4.3±2.9)分钟,传统手术组为(7.8±2.9)分钟,两组比较差异具有显著性(t=18.61,P<0.05)。结论微管微创人工流产术较传统负压吸宫术,孕妇痛苦小,出血量少,流产成功率高,是终止早期妊娠的理想选择方案。     

Clinicopathologic features and clinical outcomes of intravenous leiomyomatosis of the uterus: A case series

Rationale:Intravenous leiomyomatosis (IVL) is a rare and special type of smooth muscle tumor originating in the uterus. It is classified as a benign disease according to its histological features but shows the behavioral characteristics of a malignant tumor. It is easily misdiagnosed and recurrent. The purpose of this study was to retrospectively analyze clinicopathological data of 25 cases of IVL in order to enhance clinicians’ understanding of this rare disease.Patient concerns:We screened and identified 25 cases of IVL at our hospital from October 2013 to January 2020. Five patients had tumors.Diagnoses:The diagnosis in each case was pathologically confirmed after surgical treatment.Interventions:All patients were managed surgically. Although the surgical procedures were different, the surgical approach was geared towards achieving complete excision. Three patients received hormonal therapy with gonadotropinreleasing hormone agonists after surgery.Outcomes:We retrospectively reviewed all medical records and analyzed the clinicopathologic features and clinical outcomes of this disease as well as the correlations between the clinical features and risk of recurrence. Neither the symptoms nor the preoperative imaging results were suggestive of IVL in any of the cases. Except for two patients who were lost to follow-up, twenty-three patients who were followed up are still alive. Three patients experienced a recurrence.Lessons:The clinical manifestations and ultrasound images of IVL in the early stages are not typical; thus, IVL is easily misdiagnosed as uterine leiomyoma. Radiologists, pathologists, and surgeons should have a thorough understanding of IVL and a high index of vigilance for IVL in clinical practice. Surgery should always be aimed at achieving complete tumor excision. Patients with large lesions (≥7 cm) and lesions extending to the broad ligament may have an increased risk of recurrence. Early detection, diagnosis, and treatment are very important; once the diagnosis is confirmed, regular follow-ups are crucial.     

郭霞珍教授活血化瘀法治疗青春期崩漏经验

郭霞珍教授认为肝脾肾三脏的功能失调与青春期崩漏的发生关系密切,如肝郁血热、脾虚失摄、肾精不足等。无论何种原因导致的崩漏,血出日久,或过用固涩药物止血,最终均可发展为血瘀。故临床治疗应以活血化瘀以澄其源,同时针对"瘀"形成的不同原因,佐以疏肝清热、健脾益气或补肾填精,方能取得预期疗效。     

Parp‐1 deficiency in ES cells promotes invasive and metastatic lesions accompanying induction of trophoblast giant cells during tumorigenesis in uterine environment

Embryonic stem (ES) cells deficient in poly(ADP‐ribose) polymerase‐1 (Parp‐1) develop into teratocarcinomas with the appearance of trophoblast giant cells (TGCs) when injected subcutaneously into nude mice. Because the uterus is one of the original organs in which germ cell tumors develop with induction of trophoblast lineage, here we investigated whether Parp‐1 deficiency in ES cells affects teratocarcinoma formation processes by grafting ES cells into the horns of uteri. Teratocarcinomas developed from both wild‐type (Parp‐1^+/+) and Parp‐1^?/? ES cells. The weights of the tumors derived from Parp‐1^?/? ES cells were lower than those of the tumors derived from Parp‐1^+/+ ES cells (P < 0.05). The Parp‐1^?/? tumors showed the appearance of TGCs. Notably, organ metastasis to the lung and liver was observed for the Parp‐1^?/? tumors, but not for the Parp‐1^+/+ tumors (P < 0.05). Invasions were more frequently observed with the Parp‐1^?/? tumors compared with the Parp‐1^+/+ tumors (P < 0.05). Since TGCs are known to have invasive properties, the appearance of TGCs may have supported the metastatic process. The present findings suggest that loss of Parp‐1 during teratocarcinoma formation might augment invasive and metastatic properties of the tumors in the uterine environment.     

腹腔镜下经腹腔腹膜前疝修补术中子宫圆韧带的处理

目的探讨针对女性腹股沟疝患者行腹腔镜下经腹腔腹膜前疝修补术(TAPP)中处理子宫圆韧带的方法。方法回顾分析该院普外科自2011年1月-2014年1月,共34例女性腹股沟疝患者行TAPP的临床资料及手术录像,其中,保留子宫圆韧带25例(A组),离断子宫圆韧带9例(B组)。结果 34例手术均顺利完成,A和B两组手术时间分别为(44±8)min和(36±7)min。术后患者均恢复理想,平均随访17个月,无疝复发及慢性疼痛发生。结论与离断子宫圆韧带手术相比,沿子宫圆韧带两侧纵向切开腹膜,保留子宫圆韧带的手术操作相对复杂,用时较长,但可保证子宫圆韧带及腹膜的完整性,临床应用前景及推广价值较高。     

三维超声诊断纵膈子宫准确性及可行性分析

目的：探讨三维超声诊断纵膈子宫的准确性和可行性。方法选取我院2012－02～2013－02间经3D－TVS或宫腔镜诊断为纵膈子宫的60例患者为研究对象,将其中具有反复自然流产或不孕的30例患者作为实验组,将无不良生育病史的30例患者作为对照组。采用三维超声重建患者子宫三维图像,计算纵膈长度、宽度,并计算宫腔变形率,经统计学处理,推测导致不良妊娠结局的高危因素。对高危因素患者行宫腔手术切除子宫纵膈,比较两组患者术后宫腔形态、妊娠次数、妊娠结局及妊娠并发症。结果实验组宫腔测量值及宫颈变形率明显差于对照组,比较有统计学意义（ P＜0.05）;ROC工作曲线分析得出宫腔变形率最佳阈值为51％;术后12个月实验组妊娠并发症发生率为10.71％,对照组妊娠并发症发生率为6.90％,两组比较无统计学意义（ P＞0.05）。结论三维超声诊断纵膈子宫具有较高的准确性,可指导临床采取治疗措施,提高患者受孕几率,减少妊娠并发症及不良结局发生,值得在临床中推广应用。     

Uterine intravenous lipoleiomyomatosis: uncommon manifestation as a huge retroperitoneal mass with intracaval/intracardiac extensions

Lipoleiomyomas are benign mesenchymal tumours of smooth muscle and adipose tissue and uncommonly occur in the uterus. Here we report a case of uterine lipoleiomyoma that manifested purely as intravenous component and clinically presented as a large retroperitoneal mass with extension into inferior vena cava and right atrium. The connection of the mass to the corneal end of the uterus was noted only at surgery.     

Black cohosh inhibits 17β-estradiol-induced cell proliferation of endometrial adenocarcinoma cells

This study was conducted to investigate the effect of black cohosh (BC) extract on the proliferation and apoptosis of Ishikawa cells. Ishikawa human endometrial adenocarcinoma cells were treated with or without BC (1, 5, 10 and 25?μM) and cell proliferation and cytotoxicity were measured by CCK-8 assays and flow cytometry analysis. Additionally, Ishikawa cells were treated with 17β-estradiol (E2), E2?+?progesterone and E2?+?BC (5 and 10?μM) and the effect of BC and progesterone on E2-induced cell proliferation was analyzed. BC decreased the proliferation of Ishikawa cells at a dose-dependent rate compared with the control group (p?p?相似文献