全文获取类型
收费全文 | 17244篇 |
免费 | 1529篇 |
国内免费 | 366篇 |
专业分类
耳鼻咽喉 | 329篇 |
儿科学 | 609篇 |
妇产科学 | 44篇 |
基础医学 | 1700篇 |
口腔科学 | 100篇 |
临床医学 | 897篇 |
内科学 | 616篇 |
皮肤病学 | 31篇 |
神经病学 | 10116篇 |
特种医学 | 425篇 |
外科学 | 819篇 |
综合类 | 1517篇 |
现状与发展 | 1篇 |
预防医学 | 369篇 |
眼科学 | 197篇 |
药学 | 982篇 |
6篇 | |
中国医学 | 245篇 |
肿瘤学 | 136篇 |
出版年
2024年 | 62篇 |
2023年 | 395篇 |
2022年 | 336篇 |
2021年 | 514篇 |
2020年 | 676篇 |
2019年 | 636篇 |
2018年 | 566篇 |
2017年 | 575篇 |
2016年 | 612篇 |
2015年 | 579篇 |
2014年 | 976篇 |
2013年 | 1022篇 |
2012年 | 882篇 |
2011年 | 959篇 |
2010年 | 751篇 |
2009年 | 794篇 |
2008年 | 854篇 |
2007年 | 842篇 |
2006年 | 817篇 |
2005年 | 666篇 |
2004年 | 600篇 |
2003年 | 542篇 |
2002年 | 448篇 |
2001年 | 402篇 |
2000年 | 328篇 |
1999年 | 295篇 |
1998年 | 293篇 |
1997年 | 292篇 |
1996年 | 239篇 |
1995年 | 228篇 |
1994年 | 217篇 |
1993年 | 144篇 |
1992年 | 175篇 |
1991年 | 156篇 |
1990年 | 115篇 |
1989年 | 109篇 |
1988年 | 89篇 |
1987年 | 84篇 |
1986年 | 118篇 |
1985年 | 124篇 |
1984年 | 104篇 |
1983年 | 100篇 |
1982年 | 87篇 |
1981年 | 74篇 |
1980年 | 66篇 |
1979年 | 52篇 |
1978年 | 36篇 |
1977年 | 19篇 |
1976年 | 24篇 |
1974年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Patrick E. Barta Richard E. Powers Elizabeth H. Aylward Gary A. Chase Gordon J. Harris Peter V. Rabins Larry E. Tune Godfrey D. Pearlson 《Psychiatry Research: Neuroimaging》1997,68(2-3):65-75
Volumes of medial and lateral temporal lobe structures were assessed using magnetic resonance imaging (MRI) in 11 patients with late-life onset schizophrenia (LOS), 18 normal elderly controls and 12 patients with moderate cognitive impairment due to Alzheimer's disease (AD) who had no non-cognitive symptoms. While both patient groups has smaller volumes of several medial temporal regions (e.g. entorhinal cortex, left hippocampus), schizophrenics had significantly smaller anterior superior temporal gyri (STG) than normal controls, but AD patients did not. We have previously demonstrated anterior STG volume to be reduced in early life onset schizophrenia. 相似文献
22.
S. Lehéricy F. Semah D. Hasboun D. Dormont S. Clémenceau O. Granat C. Marsault M. Baulac 《Neuroradiology》1997,39(11):788-796
MRI was performed in 222 consecutive adult patients with temporal lobe epilepsy of varying severity from January 1991 to
May 1993. The diagnosis of hippocampal sclerosis was established visually by three independent observers. The accuracy of
visual assessment of hippocampal asymmetry was compared with volumetric measurements. Neuropathological correlations were
obtained in 63 patients with refractory seizures. Temporal lobe abnormalities were observed in 180 patients (81 %) as follows:
hippocampal sclerosis in 122 (55 %); developmental abnormalities in 16 (7.2 %); tumours in 15 (6.8 %); scars in 11 (5 %);
cavernous angiomas in 10 (4.5 %); miscellaneous lesions in 6. MRI was normal or showed unrelated changes in 42 patients (19
%). Visual assessment correctly lateralised hippocampal sclerosis in 79 of the 84 patients measured (94 %). Temporal lobectomy
confirmed the MRI data (side and aetiology) in all 63 operated patients. Patients with normal MRI had an older age of seizure
onset and were more often drug-responsive than patients with hippocampal sclerosis. MRI showed temporal lobe abnormalities
in 81 % of epileptic patients with varying severity with good neuropathological correlation. Patients with normal MRI had
a less severe form of the disease.
Received: 19 August 1996 Accepted: 13 November 1996 相似文献
23.
Summary 67 cases of brain abscess were analyzed retrospectively. As 2 comatose patients died on admission before any treatment was started, the results are based on 65 treated patients. Different methods of treatment included: total removal in 36 patients, drainage in 14, aspiration in 6 and conservative treatment in 9. Management mortality was 18,5% and was almost not dependent on the method of treatment (except aspiration) being lowest in the drainage group. The mortality was significantly higher in patients with serious impairment of consciousness on admission.Follow-up examination after 1 to 11 years was performed in 47 out of 53 discharged patients and revealed in 25 of them (53%) full recovery. 10 additional cases (21%) are independent. The best early and long term results were obtained in patients by drainage and medical treatment.Chronic epilepsy developed in 34% of patients with supratentorial lesions. The risk of epilepsy was lowest in the group of patients treated by drainage.The authors present the opinion that removal of brain abscess is necessary only in exceptional cases. 相似文献
24.
Objective To investigate the roles of somatostatin(SS)positive intemeurons in the development and compensation of temporal lobe epilepsy.Methods Piloearpine-induced epilepsy rat model was established.Immunohistochemistry method was used to detect number changes and axonal sprouting of SS positive intemeurons in different domains of the hippocampus at difierent time points.Degeneration of SS positive interneurons and their neurophils were detected by the double immunofluorescence staining with SS and Fluoro-Jade B(FJB)at 7 and 60 days after status epilepticus (SE).Results In the exoerimental rat group,the number of SS positive neurons decreased in each hippocampal domain,and it reached the lowest at 7 days post-SE(There were 11.1±3.3 in hilus,2.8±0.9 in CA1region and 1.8±0.7 in CA1region,t=13.519,9.644 and 8.808,all P<0.01).In chronic phase,the number of SS neurons gradually recovered,and exceeded the control group in CA1 area at 60 days post-SE(12.8±1.5 vs 8.8±1.3,t=-4.506,P<0.01),however,the number of SS neurons in the hilus(25.5±4.6)and CA1 area(4.8±0.8)remained significantly less than normal levels(t value were 4.691 and 3.953.both P<0.01).Increased SS positive fibers were found in the lacunosum-molecular (1m)layer and outer molecular layer of dentate gyrus after 30 days post-SE,and numerous SS positive fibers were seen threnghout the layers of area CA1 at 60 days post-SE.Double immunofluuorescence revealed that a few SS positive interneurons and fibers were also labeled by FJB in area CA1 at 7 days post-SE and in CA domain/hilus at 60 days post-SE.Conclusions SS intemeurons loss plays an important role in the development of temporal lobe epilepsy.The loss is partially caIlsed by the degeneration and death of neurons;SS positive neurophils increase within area CA1 in chronic phase may play a significant role in the generation and compensation of temporal lobe epilepsy. 相似文献
25.
Kuo-Sheng Hung MD Phd Chung-Ling Liang MD Cheng-Haung Wang MD Hsueh-Wen Chang PhD Naeun Park MS Suh-Hang Hank Juo MD PhD 《Journal of clinical neuroscience》2004,11(8):849-853
Frontal intracerebral haemorrhage (ICH) is a common result of cranial trauma. Outcome differences between bilateral and unilateral frontal ICH are not well studied but would be valuable to predict prognosis in clinical practice. Two aims are proposed in this study: first to compare the risk of developing delayed ICH after bilateral or unilateral frontal ICH, and second to determine the variables helpful to predict outcome according to the Glasgow Outcome Scale (GOS). Between January 1993 and December 1997, 694 consecutive patients with traumatic ICH were admitted to the Chang Gung Medical Center within 24 h of the trauma. Patients with ICH in sites other than the frontal lobes were excluded. A total of 161 cases (mean age 46.3+/-20.3 years), including 57 bilateral (mean age 52.5+/-18.7 years) and 104 unilateral (mean age 42.9+/-20.5 years) traumatic frontal ICH were studied. Twenty-eight of 57 patients (49%) with bifrontal ICH versus 17 of 104 patients (16%) with unilateral frontal ICH had a further, delayed ICH. In 42 of 45 patients (93%) with delayed ICH, this occurred within 5 days of the initial trauma. Multivariate logistic regression was used to select significant predictors of outcome. We found that delayed ICH (p<0.001), age (p=0.004) and mechanism of injury (p=0.001) explained the worse outcome in patients with bifrontal ICH. The best-fitting logistic regression model included three variables: delayed ICH (p=0.011), initial GCS (p=0.023), and a sum score of clinical and radiological variables (p=0.003). Bifrontal ICH tended to occur in older patients after a fall and was associated with a higher risk of developing delayed ICH or brain stem compression compared to unilateral ICH damage. Using these three variables - delayed ICH, initial GCS, and the sum score - in a logistical regression model is useful to predict outcome in patients with traumatic frontal ICH and may aid patient management. 相似文献
26.
目的:加巴喷丁抗癫痫作用的有效性与安全性。方法:随机双盲,添加治疗安慰剂对照临床试验。整个试验历时6个月,入选者随机分入试验组或对照组,于试验前、入组后第1、4、8、12、16、20、24周末随访。结果:均衡性:加巴喷丁治疗癫痫在随访中均衡性较好,各指标间无明显差别。疗效评价:加巴喷丁添加治疗组结果显示较安慰剂组发作次数明显减少,两组间有统计学差别;对各类型癫痫总的治疗有效率及MMSE评分等方面无统计学差异,未显示出疗效;但对全身性强直阵挛发作类型具有明显疗效,具有统计学意义。安全性评价:加巴喷丁组和安慰剂组都有不良事件发生,加巴喷丁组居多,但差别无统计学意义。结论:加巴喷丁对全身性强直阵挛发作类型有效,对其它类型疗效不佳,是一种安全性较好的药物。 相似文献
27.
目的:观察24小时动态脑电图与视频脑电图对癫发作类型鉴别的价值。方法:242例患者进行24小时视频脑电监测,陪同家属做记录。结果由两名医师判定,一人关闭视频进行分析作为动态脑电组。一人打开视频分析作为视频脑电组。结果:242例患者中63例临床发作伴癫样放电,视频脑电监测后符合例数53例(84%),动态脑电监测后符合例数39例(61·9%),有显著性差异。结论:视频脑电监测与动态脑电图对癫发作类型的鉴别有显著的差异,视频脑电图更准确。 相似文献
28.
目的 研究细胞周期依赖性蛋白激酶5(cyclin dependent kinases 5,CDK5)在耐药性癫(癎)患者颞叶中的表达,探索其在耐药性癫(癎)发病机制中的作用.方法 收集耐药性癫(癎)患者术后脑组织,用荧光定量PCR、免疫组化和Western blot 3种检测方法从基因和蛋白水平分别测定CDK5在耐药性癫(癎)患者颞叶中的表达,并与对照组进行比较.结果 荧光定量PCR发现CDK5 mRAN比对照组明显增加,免疫组化检测显示这种基因的蛋白表达产物主要分布在神经元轴突和胶质细胞中,Western blot检测在相对分子质量35 000处有一蛋白条带,并且可见实验组(颞叶和海马中分别为1.4293±0.1839和2.0733±0.4738)高于对照组(颞叶和海马中分别为0.9680±0.4147和1.403±0.6163,P<0.05).结论 CDK5在耐药性癫(癎)患者颞叶中表达增强,提示他们可能参与了耐药性癫(癎)的形成. 相似文献
29.
Patientsfeelimpatientbecausetheycouldnotpredicttheonsettimeofepilepsy.Ifonsettimeofepilepsycouldbepreciselypredicted,thendrugadministrationanddisabilityofpreventionwillbecomeavailable.In1879,Echevarrzafoundonsettimeofepilepsyisdistributedaccordingtosomerules.Inrecentyears,scientistsperformalotstudiesinvolvingcytologyandmolecularbiologyofepilepsy.Clinicaldataindicatedonsetofepilepsyhascloserelationwithbiologicalrhythmsuchasawakeandsleepcycleandmenstrualcycle.Theobjectiveofthisstudy… 相似文献
30.