6种氧氟沙星滴眼液产品质量考察

目的:考察6个厂家氧氟沙星滴眼液的产品质量,供医院用药参考.方法:通过光照(2 800lx)、高温(60℃)、低温(0～10℃)试验10 d,恒温加速试验(40℃,RH 75%)1 80 d,室温(0～35℃)留样1年等多种条件考察,检测其色泽,pH值、含量及有关物质(分解产物)的变化.结果:6个厂家产品质量均稳定,有效期都在2年以上.紫色抗光塑料瓶包装比白色(透光)塑料瓶包装的产品质量更稳定.结论:6个厂家产品质量均符合2000年版和2005年版<中国药典(二部)>要求.     

紫外分光光度法测定氧氟沙星胶囊的含量

本文报道了以0.1mol／L盐酸溶液为溶剂，采用紫外分光光度法测定氧氟沙星胶囊的含量的方法，其平均回收率99.51％，RSD=0．60％，n=9；样品含量测定的平均RSD为0．90％，n=6。     

复曲膏的制备及质量控制

目的：制备复曲膏并建立其质量控制方法。方法：以醋酸曲安奈德和氧氟沙星为主药制备复曲膏，采用高效液相色语法测定复曲膏中醋酸曲安奈德和氧氟沙星的含量。结果：醋酸曲安奈德和氧氟沙星的平均回收率分别为100．3％和100．0％，RSD分别为0．38％和0．41％。结论：该制剂工艺简便易行，其质量控制方法简单、快速，准确。     

氧氟沙星不同给药方案治疗伤寒的经济学分析

运用药物经济学成本-效果分析法寻找治疗伤寒的最佳方案.根据文献数据,对104例伤寒患者,分别采用氧氟沙星序贯给药、连续静脉滴注以及口服给药治疗的临床效果进行成本效果分析.结果显示,3种治疗方法的治愈率相似(P》0.05),序贯疗法和静脉疗法的完全退热时间相似(P》0.05),序贯疗法和口服疗法的完全退热时间有显著差异(P《0.01),序贯治疗组的抗菌素费用及医疗总费用低于静脉治疗组,高于口服治疗组.从药物经济学角度看,序贯疗法是3种氧氟沙星治疗伤寒方案中的最佳方案.     

氧氟沙星治疗社区获得性肺炎90例临床观察

目的　探讨氧氟沙星治疗社区获得性肺炎的疗效。方法　静脉滴注氧氟沙星 0 .4 g,每 12小时 1次 ,疗程 7～ 14 d。结果　总有效率 93.3%。结论　氧氟沙星治疗社区获得性肺炎安全有效。     

Effects of combination therapy with interferon and ofloxacin on chronic type C hepatitis: A pilot study

Interferon is effective in only a limited number of patients with the 1b type of hepatitis C virus (HCV), indicating that a combination therapy with other antiviral drugs may be essential to obtain better results. In the present pilot study, the effects of a combination therapy with interferon (IFN) and an antibacterial drug, ofloxacin, were analysed. Ten patients with chronic type C hepatitis received the combination therapy (combination group). Six million units of natural IFN-α were administered daily for 3 weeks and then three times a week for 21 weeks. The combination therapy was initiated at the beginning of the eighth week of IFN treatment and 600 mg ofloxacin per day was administered for 12 weeks. As a control, changes in HCV-RNA were also analysed in patients who were treated with only IFN for the same period (IFN-alone group). In the combination group, serum transaminase levels and the titres of HCV decreased significantly with ofloxacin administration. Such changes were not observed in the IFN-alone group. The incidence of HCV-negativity at the end of ofloxacin administration of the combination group was significantly higher than in the IFN-alone group. The complete response rate was twice as high in the combination group as in the IFN-alone group. In two patients who did not respond well to the IFN-alone treatment, ofloxacin administration was commenced after the 24th week. Serum transaminase levels were normalized and HCV-RNA became negative in these two patients after the administration of ofloxacin. These results suggest that combination therapy with IFN and ofloxacin may be an effective treatment for chronic type C hepatitis.     

五厂家氧氟沙星片的溶出度比较

本文为考核片剂内在质量，控制药物的均匀性，为评定产品质量提供方法与参数，按照中国药典“溶出度测定法”，对五厂家的氧氟沙星片进行了溶出度对比实验，经过统计学处理的结果表明有显著差异（Ｐ＜０．０１）。不同厂家生产的同类产品质量对溶出度有显著影响。     

紫外分光光度法测定氧麻滴鼻液中氧氟沙星的含量

本文作者应用紫外分光光度法测定氧麻滴鼻液中氧氟沙星的含量。在1.5～21μg/ml的浓度范围,氧氟沙星的吸收度与浓度呈良好的线性关系;平均回收率为100.07％,RSD=0.16％(n=5),并具有灵敏、快速、特异、简便、重现性好、回收率高的特点。     

聚结晶紫薄膜修饰电极对氧氟沙星的电催化作用

目的:利用循环伏安法电聚合制备出对氧氟沙星(OFX)具有良好电催化作用的聚结晶紫薄膜修饰电极(PCVE),建立一种对 OFX 进行定量测定的新的电化学分析方法。方法:在0.050 mol·L~(-1)硫酸钠溶液 0.08 mol·L~(-1)。醋酸-醋酸钠缓冲液(pH=4.4)体系中,于0.4～1.2 V 范围内,以100 mV·s~(-1)的扫描速率进行循环伏安分析。结果:氧氟沙星的线性范围为1.6×10~(-7)～2.0×10~(-4)mol·L~(-1),r=0.9995,检测限可达8.0×10~(-9)mol·L~(-1)。样品分析的 RSD 均小于2%(n=8),回收率为95.7%～102.1%。结论:PCVE 制备简单、稳定性好。该方法是一种灵敏、准确测定样品中微量 OFX 的新的电化学分析方法。     

Maintaining fluoroquinolone class efficacy: review of influencing factors

Previous experience with antimicrobial resistance has emphasized the importance of appropriate stewardship of these pharmacotherapeutic agents. The introduction of fluoroquinolones provided potent new drugs directed primarily against gram-negative pathogens, while the newer members of this class demonstrate more activity against gram-positive species, including Streptococcus pneumoniae. Although these agents are clinically effective against a broad range of infectious agents, emergence of resistance and associated clinical failures have prompted reexamination of their use. Appropriate use revolves around two key objectives: 1) only prescribing antimicrobial therapy when it is beneficial and 2) using the agents with optimal activity against the expected pathogens. Pharmacodynamic principles and properties can be applied to achieve the latter objective when prescribing agents belonging to the fluoroquinolone class. A focused approach emphasizing "correct-spectrum" coverage may reduce development of antimicrobial resistance and maintain class efficacy.