逍遥颗粒配合百优解治疗抑郁性神经症的近期临床研究

目的　探讨逍遥颗粒配合百优解治疗抑郁性神经症的近期临床疗效。方法　选择 5 0例抑郁性神经症患者 ,随机分为治疗组 (逍遥颗粒合用百优解 )和对照组 (百优解 ) ,治疗 3周 ,观察Zung氏自评量表分值、总有效率及副作用。结果　治疗组比对照组Zung氏自评量表分值下降明显 (P<0 0 5 ) ,总有效率高 (P <0 0 5 ) ,副作用少 (P <0 0 5 )。结论　逍遥颗粒配合百优解治疗抑郁性神经症可以提高近期临床疗效 ,减少副作用并增加患者依从性     

纵隔气肿诊断为心血管神经症一例报告

【】本文报告一例纵隔气肿诊断为心血管神经症,患者,女,39岁,主因“间断心悸、气短1天”入院。患者于1天前情绪激动大笑后出现心悸、气短,心率偏快,无明显阳性体征,心血管方面的观察及医疗器械检查均未发现器质性心脏病的表现,予吸氧、控制心室率、扩冠、改善循环等治疗未见明显好转,入院诊断为“心血管神经症”,未能在第一时间明确诊断,直到入院后行胸部CT诊断为纵隔气肿。提示在诊断纵膈气肿时,应结合病史,避免误诊。     

应用心理与行为问题评估提高心血管神经症治疗效果

目的：探讨使用心理与行为问题评估指导心血管神经症治疗的效果。方法将57例心血管神经症患者随机分为2组,实验组29例,对照组28例。于治疗前和治疗第4、8、12周末时,采用90项症状清单（SCL-90）、抑郁自评量表（SDS）、焦虑自评量表（SAS）3个量表对患者进行心理与行为问题评估。实验组根据测量结果指导用药时机、选择心理干预方式。对照组按常规心血管药物进行诊治。治疗3个月后,收集所有患者有关治疗效果、疗程、量表分数。结果治疗8周后,实验组的抑郁和焦虑程度均比对照组明显减轻,差异有统计学意义（P〈0.05）;治疗12周后,实验组治疗效果明显比对照组提高,差异有统计学意义（P＜0.05）。结论使用心理与行为问题评估指导心血管神经症治疗,优于一直以来按常规心血管药物治疗的效果。     

Anxiety disorders: a long-term prospective and retrospective follow-up study of former inpatients suffering from an anxiety neurosis or phobia

Psychopathological status and psychosocial functioning of 40 former inpatients suffering from an anxiety neurosis (ICD 300.0) or phobia (ICD 300.2) were followed up over a period of 6-8 years using standardized instruments. In addition, the course of illness, the utilization of medical services and the periods of work disabilities were assessed. With regard to psychopathology, in more than half of the patients course and outcome could be regarded as chronic and severe; only one third of the patients were free of marked or severe psychopathological symptoms during the 12 months preceding the reexamination. Although on the psychosocial outcome level 67% of the 40 former inpatients showed marked or severe difficulties in most social role areas, especially in the field of personal interaction, the great majority of these patients seemed to have adapted somehow to their life situations. Only 13% could be regarded as severely impaired and in continuous need of supervision and guidance. Coping difficulties with everyday demands and dissatisfaction with their social functioning and their anxiety-related restrictions were most prominent in all anxious patients. In contrast to some other long-term follow-up studies, most of which were carried out on outpatients, the results suggest a rather unfavourable course and outcome of anxiety disorders.     

Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated

The 5-HT_2B receptor agonist, BW 723C86 (10, 30 mg/kg i.p. 30 min pre-test), increased the number of punishments accepted in a rat Vogel drinking conflict paradigm over 3 min, as did the benzodiazepine anxiolytics, chlordiazepoxide (2.5–10 mg/kg p.o. 1 h pre-test) and alprazolam (0.2–5 mg/kg p.o. 1 h pre-test), but not the 5-HT_2C/2B receptor agonist, m-chlorophenylpiperazine (mCPP, 0.3–3 mg/kg i.p) or the 5-HT_1A receptor agonist, buspirone (5–20 mg/kg p.o. 1 h pre-test). The effect of BW 723C86 was unlikely to be secondary to enhanced thirst, as BW 723C86 did not increase the time that rats with free access to water spent drinking, nor did it reduce sensitivity to shock in the apparatus. The anti-punishment effect of BW 723C86 was opposed by prior treatment with the 5-HT_2C/2B receptor antagonist, SB-206553 (10 and 20 mg/kg p.o. 1 h pre-test), and the selective 5-HT_2B receptor antagonist, SB-215505 (1 and 3 mg/kg p.o. 1 h pre-test), but not by the selective 5-HT_2C receptor antagonist, SB-242084 (5 mg/kg p.o.), or the 5-HT_1A receptor antagonist, WAY 100635 (0.1 or 0.3 mg/kg s.c. 30 min pre-test). Thus, the anti-punishment action of BW 723C86 is likely to be 5-HT_2B receptor mediated. This is consistent with previous reports that BW 723C86 exhibited anxiolytic-like properties in both the social interaction and Geller-Seifter conflict tests.     

CCK in Anxiety and Cognitive Processes

DAUGÉ, V. AND I. LÉNA. CCK in anxiety and cognitive processes. NEUROSCI BIOBEHAV REV 22(6) 815–825, 1998.—Extensive studies were carried out on the involvement of the CCKergic system in anxiety-, panic- and stress-related behaviour. The stimulation of CCK-A or CCK-B receptors is implicated in the physical and psychological responses of CCK to stress. Furthermore, several selective CCK-B agonists produce anxiogenic-like effects, while CCK-B antagonists induce anxiolytic-like responses in several models of anxiety. However, BC264 a highly selective CCK-B agonist, does not produce anxiogenic-like effects but increases attention and/or memory. These effects are dependent on the dopaminergic systems. Together with biochemical data, this led to the hypothesis of the existence of two CCK-B binding sites, CCK-B1 and CCK-B2, which could correspond to different activation states of a single molecular entity. Investigations into CCK-B1 and CCK-B2 systems might be of critical interest, since only one site, CCK-B1, appears to be responsible for the effects on anxiety. Furthermore, the improvement of attention and/or memory processes by CCK, through CCK-B2 receptors, could offer a new perspective in the treatment of attention and/or memory disorders.     

电针与美抒玉治疗焦虑症临床疗效对照观察

目的：评价电针治疗广泛性焦虑症的临床疗效。方法：将62例临床诊断为广泛性焦虑症的患者，随机分为电针组(治疗组)和美抒玉药物组(对照组)，治疗6周，于治疗前、治疗过程中第2、4、6周末分别采用哈密顿焦虑量表(HAMA)、焦虑自评量表(SAS)、抑郁自评量表(SDS)进行疗效评定。结果：电针组显效率为66％，药物组显效率为59％。结论：电针治疗广泛性焦虑症有明显疗效，且见效较美抒玉稍快，安全、舒适、无副反应。     

Relationship between Sibship Size and Neurotic Symptoms of Anxiety, Hypochondriasis and Depression in Japanese Neurotic Children and Adolescents

Abstract: Two hundred and sixty-eight Japanese aged 19 or below were studied retrospectively from their medical records to determine the relationship between the sibship size (number of siblings in the family) and the appearance of symptoms of anxiety, hypochondriasis and depression during the time period I (1955 + 1960 + 1965) and the time period II (1970 + 1975 + 1978). The results showed that only sons and either sex of a large sibship size (4 or more) possessed these three symptoms to a larger extent than only daughters and either sex of a medium sibship size (2 or 3) during both time periods. These three adult-type neurotic symptoms were thought to be manifested among the children and adolescents who communicated primarily with adults and/or those who were required by their parents to exhibit adult-type behavior whether in traditional or in modern Japanese families.     

Effects of Litigation Settlements on Posttraumatic Stress Symptoms in Motor Vehicle Accident Victims

In order to investigate the effects of the initiation of litigation and its settlement on victims of motor vehicle accidents (MVAs), we followed up 132 MVA victims from an initial assessment 1 to 4 months post-MVA for 1 year. Of the 67 who had initiated litigation. 18 (27%) settled within the 12 months, while 49 still had litigation pending; 65 never initiated litigation. Those who initiated litigation had more severe injuries and higher initial levels of posttraumatic stress (PTS) symptoms. All three groups improved in major role function and had reduced PTS symptoms over the 1 year follow-up. Those whose suits were still pending, as well as those whose suits had been settled, showed no reduction in measures of anxiety or depression, whereas the nonlitigants did show improvement on these measures.     

针刺治疗抑郁性神经症的临床疗效观察

目的　观察针刺治疗抑郁性神经症的疗效 ,并与黛力新进行疗效比较。方法　以CCMD 2 R为标准选取 4 1例抑郁性神经症患者 ,随机分为针刺组 2 1例及西药组 2 0例。针刺组以针刺治疗两个疗程共 2 0次 ,西药组服用黛力新治疗 2 0d ,治疗结束后以汉密顿抑郁量表HAMD评分 ,以减分率评定疗效 ,并加以比较。结果　每组治疗前后HAMD评分比较均有显著性差异 (P <0 0 1) ,两组治疗后评分及临床疗效比较无显著性差异 (P >0 0 5 )。结论　针刺治疗抑郁性神经症疗效与西药黛力新相当 ,针刺可作为治疗抑郁性神经症的一种替代疗法 ,避免西药的毒副作用。