Endocrine mucin‐producing sweat gland carcinoma occurring on extra‐facial site: a case report

Cutaneous endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is a very rare low‐grade malignant neoplasm analogous to the mammary solid‐papillary carcinoma. It frequently expresses neuroendocrine markers and may show mucinous differentiation. Although the nodules are circumscribed, myoepithelial cells cannot be showed in most cases and about half of the cases are associated with invasive mucinous carcinoma. Hence, it has been suggested to be invasive and the precursor lesion of some primary cutaneous mucinous carcinomas. After being recognized as a distinct entity, all cases reported to date occurred either in the periocular region or on the cheek. Two thirds of the patients were female. Herein we present an unusual case of in situ EMPSGC on the chest wall skin of a middle‐aged man.     

人卵巢粘液性囊腺癌细胞系的建立及生物学特性的研究

目的 探讨人卵巢粘液性囊腺癌细胞系的建立,并研究其生物学特性。方法 用贴壁培养法建立细胞系,冷冻保存。用光学显微镜、电子显微镜观察细胞系的形态,研究细胞系的生长及生物学持性。结果 国内第1株人卵巢粘液性囊腺癌细胞系建立成功,命名为OMC685,现已传至91代,冷冻8年多复苏后仍生长良好。其生物学特性为,形态学观察证实该细胞系具有腺上皮癌细胞的特点;细胞生长旺盛;植物血凝素凝集试验阳性;染色体为亚三倍体,有畸变;异种动物移植阳性;免疫组织化学酸性粘液染色阳性;雌二醇及黄体酮阳性;无支原体及病毒污染;对脊髓灰质炎病毒I型、腺病毒7型及麻疹病毒敏感。结论 OMC685是一株独特的人卵巢癌细胞系。     

胰腺导管内乳头状黏液性肿瘤的CT诊断

目的:探讨胰腺导管内乳头状黏液性肿瘤(IPMN)的螺旋CT诊断价值。材料和方法:回顾性分析经手术病理证实的14例胰腺IPMN的螺旋CT表现。结果:主胰管型IPMN3例,表现为主胰管扩张伴管壁结节样突起;分支胰管型IPMN5例,表现为分叶状单发囊性病变或葡萄串样多发囊性病变伴腔内分隔或结节样突起;混合型IPMN6例,表现为主胰管扩张和囊性病变合并存在。CT诊断IPMN恶变6例,病理诊断导管内乳头状黏液腺癌7例。结论:螺旋CT能够显示胰腺IPMN的病理特征,并可做出分型。     

Clinicopathologic evaluation of mucin-producing tumor of the pancreas

We studied the diagnostic problems, surgical management, and histopathologic characteristics of 28 patients with intra-ductal tumors and mucinous cystadenomas of the pancreas who underwent surgical resection. Endoscopic ultrasonography (EUS) and endoscopic retrograde pancreatography (ERP) were the most useful means for confident diagnosis of the diseases. New diagnostic modalities, including intra-pancreatic ductal endoscopy and intraductal ultrasonography, also improved the qualitative diagnosis of these tumors. Minimally invasive surgery i.e., duodenum-and choledochus-preserving resection of the head of the pancreas, was conducted in our patients. The long-term results were good and no patients had disease recurrence. Although these diseases are regarded as precancerous lesions of the pancreas, there were several unclear points regarding biologic behavior and the correlation with invasive cystadenocarcinoma. Thus, a molecular biological explanation concerning the roles of oncogenes such asp53 and Ki-ras in carcinogenesis is an important question that remains to be resolved.     

胰腺导管内乳头状黏液性肿瘤的临床病理学分析(附29例报告)

目的：回顾性分析胰腺导管内乳头状黏液性肿瘤（IPMT）的诊治经验及预后,以期提高对该病的治疗水平。方法：1993年5月至2006年8月,共29例IPMT病人在我院接受手术治疗,男17例,女12例。现回顾性分析其临床表现、病理学分类以及术后随访情况。结果：术后病理证实,本组共有11例是类腺瘤,2例交界性肿瘤,16例腺癌。其中,主胰管型11例,分支胰管型16例,混合型2例。2例病人由于病变累及全胰而施行全胰切除术,其余病人分别施行胰十二指肠切除术（16例）、胰体尾切除术（7例）及局部切除术（4例）。在腺癌病例中,有37.5%（6/16）发生淋巴结转移。结论：IPMT有独特的临床病理学特征。对主胰管直径≥10mm、肿瘤直径〉40mm以及主胰管型病例,应高度怀疑恶性病变的可能性。如术前考虑IPMT有恶性可能,则应施行合并淋巴结清扫的根治性切除术。     

Histological discrimination of malignancy in mucinous ovarian tumours

Eight histological features were measured quantitatively in a group of 77 ovarian mucinous carcinomas and a group of 28 benign mucinous cystomas. These were compared with the duration of survival of the patients and the clinical staging of the tumours. Using the method of discriminant function analysis it was possible to identify a group of tumours of 'borderline malignancy'. Although single histological features were inadequate indicators of prognosis a combination of three features proved fairly accurate.     

Evaluation of prostatic cancer histology and grade distribution: experience with the Colorado Central Cancer Registry

Although well-defined grading schemes for prostatic adenocarcinoma have been developed, they are not yet universally accepted by practicing surgical pathologists. The complexity of these schemes often leads surgical pathologists to develop their own modified Broders scheme. This study compared the grade distribution as obtained by a community of surgical pathologists with that obtained using the National Prostatic Cancer Project (NPCP) and Gleason grading schemes. In 1978, 308 cases of prostate cancer were reported to the Colorado Central Cancer Registry (CCCR) from the Denver Standard Metropolitan Statistical Area. Two hundred eighteen of these cases were regraded. The grade distribution as reported by the CCCR revealed a predominance of low-grade tumors (grade I-41%, grade II-28%, grade III-17%, grade IV-3%). Regrading of these same cases revealed a shift to higher grades (NPCP: grade I-14%, grade II-11%, grade III-37%, grade IV-29%; Gleason: pattern scores less than 6-30%, score 6-24%, score 7-12%, score 8-11%, score 9-10%, score 10-4%). Twenty-one cases of histologic variants which were not originally diagnosed were also noted (six mucinous, 12 ductal, two endometroioid, one squamous). There were 18 cases in which no evidence of carcinoma was confirmed. These results suggest that there is a tendency to underestimate grade and potentially malignant behavior when well-defined prostatic cancer grading schemes are not applied.     

Mucinous (colloid) adenocarcinoma

We describe a case of primary mucinous (colloid) adenocarcinoma of the lung. The patient was a 61-year-old male with a peripheral mass of the left lung. Retrospectively, the mass, which showed slow growth later, could be seen in a chest X-ray 3 years before surgery. The tumor was filled with a gelatinous substance resembling strawberry jelly, macroscopically. Microscopically, it was mucin with a small amount of malignant cells (adenocarcinoma). Diagnosis was mucinous (colloid) adenocarcinoma, which is a very rare intrapulmonary neoplasm. Mucinous (colloid) adenocarcinoma is suspected when a gelatinous substance like strawberry jelly is observed intraoperatively in the lung.