高同型半胱氨酸血症及MTHFR基因与中青年脑梗死的研究

目的 :探讨高同型半胱氨酸血症 (HHC)及N5,N10-亚甲四氢叶酸还原酶(MTHFR)基因型与中青年脑梗死的关系。方法 :采用高压液相色谱法及PCR -RFLP技术测定80例脑梗死患者和40例正常对照者的血浆总同型半胱氨酸水平 (tHcy)和MTHFR基因多态性。结果 :患者组中MTHFR基因T/T纯合型频率为33.75 % ,T等位基因频率为58.75 % ,显著高于对照组的20 %和36.25 % (P<0.05) ;患者组血浆tHcy均值为22.70μmol/L ,对照组仅为13.19μmol/L ,患者组HHC31例 ,对照组仅为2例 ,2组差别有统计学意义,且2组T/T型者血浆tHcy水平高于T/C型和C/C型者。结论 :MTHFR基因突变可能是脑梗死发生的一个遗传易感因素 ,tHcy可能与血脂血糖一样是脑卒中发病的一个独立危险因素     

甘西鼠尾草注射液和丹参注射液抗大鼠急性脑缺血和抗脂质过氧化作用的比较

目的：比较甘西鼠尾草和丹参两种注射液对大鼠急性脑缺血的影响，并对其作用机理进行探讨。方法：采用大脑中动脉阻断术（MCAO）制作大鼠急性脑缺血模型。采用计算机图像分析仪测定脑梗死的体积，TBA比色法测定血清MDA含量，放免法测定血清SOD含量；电子自旋共振（ESR）法测定药物对羟自由基的清除作用。结果：甘西鼠尾草注射液和丹参注射液均可明显减小急性脑缺血大鼠脑梗死体积，降低血清MDA含量，升高血清SOD含量，体外清除羟自由基的作用甘西鼠尾草强于丹参。结论：甘西鼠尾草和丹参两种注射液作用基本相同。提示甘西鼠尾草有可能成为丹参的代用品。     

Changes in patterns of left ventricular hypertrophy after aortic valve replacement for aortic stenosis and regurgitation with St. Jude Medical cardiac valves

In this study, we analyzed the extent and pattern of regression of left ventricular (LV) hypertrophy after aortic valve replacement in patients with aortic stenosis (AS) and compared the results with those of another group of patients with aortic regurgitation (AR). Seventy patients who underwent isolated aortic valve replacement were divided into 2 groups. Group 1 was comprised of 29 patients who underwent aortic valve replacement for aortic stenosis, and Group 2 of 41 patients who underwent aortic valve replacement for aortic regurgitation. A third group of 10 healthy subjects served as a healthy control group. Echocardiographic studies were done before the operation and 5 years postoperatively. At follow-up, a significant reduction in the left ventricular mass was found in both groups, but it remained significantly greater than in the healthy control group. The ratio of LV wall thickness to radius (th/r) in Group 1 decreased significantly, and at follow-up it was within the normal value. In Group 2, the th/r ratio increased, and at follow-up it was within the normal value. After aortic valve replacement, the wall thickness remained significantly greater than normal for patients with AS, and the chamber radius remained significantly greater than normal for patients with AR. For these reasons, LV hypertrophy still existed in both groups at postoperative follow-up. The actuarial survival rate was 85.3% at 16 years for Group 1 and 83.4% at 18 years for Group 2. There was no significant difference in the long-term survival rates between the 2 groups. Actuarial freedom from valve-related events was 91.9% at 16 years for Group 1 and 82% at 18 years for Group 2. There was no significant difference in the valve-related event free curves between groups. After 5 years of follow-up, th/r reached normal for both groups, indicating remodeling of the LV geometry after aortic valve replacement.     

Yellow nail syndrome in infancy

Abstract: This report describes an infant with clinical features consistent with the yellow nail syndrome (YNS), a rare autosomal dominant disorder. He presented at birth with congenital lymphoedema and was referred at 6 months of age for investigation of recurrent cough and wheeze. He had clinical and radiological evidence of bilateral pleural effusions and a pericardial effusion. Following a lung biopsy and pericardial window these were shown to be manifestations of his lymphatic abnormality. He also had persisting middle ear effusions causing conductive deafness requiring hearing aids and secondary immunodeficiency requiring regular immunoglobulin infusions.     

抗癌宝口服液治疗中晚期恶性肿瘤103例临床观察

目的：观察中药抗癌宝口服液治疗中晚期恶性肿瘤临床效果。方法：１０３例患者随机分为抗癌宝观察组与化疗对照组，对两组疗效作比较。结果：观察组患者免疫功能，近期有效率（ＣＲ＋ＰＲ），生存质量，１、２、３年生存期及中位生存时间，癌胚抗原下降水平，明显高于对照组，且有显著性差异。结论：抗癌宝具有抑制肿瘤生长，延长生存时间，提高生存质量之效。     

Postischemic spontaneous hyperthermia and its effects in middle cerebral artery occlusion in the rat

This study examined the time course and effects of postischemic spontaneous hyperthermia after transient and permanent focal ischemia. Rats underwent a 90-min, 120-min, or permanent middle cerebral artery occlusion (MCAO). Body temperatures started rising 15-20 min after MCAO and reached 39-40.5 degrees C during the first hour. Sustained hyperthermia was observed during the rest of the first 24 h. In another experiment, rats were subjected to the same interventions, but a normothermic body temperature was maintained. Spontaneous hyperthermia significantly increased the infarct volumes measured 48 h after MCAO in all groups. Reperfusion 2 h after the onset of ischemia was not beneficial in the hyperthermic animals in contrast to the normothermic group. We also examined the effect of spontaneous hyperthermia on the temporal progression of infarcted and penumbral areas 4, 12, or 48 h after MCAO. During spontaneous hyperthermia, penumbral areas became infarcted areas more rapidly, which was most expressed at 4 h. These findings demonstrate that severe spontaneous hyperthermia can occur in rats after MCAO and that it not only increases the infarct volumes in both transient and permanent ischemia, but also accelerates the incorporation of penumbral areas into necrotic areas, which significantly decreases the window of opportunity for therapeutic interventions.     

高一学生的人格特征比较研究

目的研究高一学生的人格特征。方法采用卡特尔16PF和MHT量表调查高一学生231名。结果(1)高一学生与一般中学生在人格上存在一定的差异,有自己的独特性,其中男生与女生的人格特征存在差异,省会城市地区学生较地州学生人格更为理想,汉族学生的人格特征略优于少数民族学生;(2)心理健康水平较高的高一学生在9个因素上表现出典型的人格特点。结论有针对性地对高一学生进行人格健康教育,纠正高一学生人格发展上的偏差,完善其人格,具有十分重要的意义。     

德清县中学生艾滋病知识、态度、行为调查

目的 了解中学生艾滋病（AIDS）知识、态度和行为及学校健康教育对其影响，为制定健康教育策略提供依据。方法 用整群随机抽样的方法，对浙江省德清县城镇和乡村学生，采取匿名自填式答卷方式进行调查。结果 中学生对艾滋病基本知识知晓率为60．9％～91．9％；传播途径知晓率为22．0％～93．1％；大部分中学生对艾滋病持正确态度，对感染者不存在歧视；大部分中学生赞同开展预防艾滋病的健康教育；城镇学生对艾滋病了解程度好于乡村学生（P〈0．05），对艾滋病感染者的歧视也更少（P〈0．05）。结论目前中学生对艾滋病的认识有一定的水平．应有针对性的开展预防艾滋病的学校健康教育，加强农村学校的艾滋病健康教育，提高青少年的自我保护意识和技能，做到知、信、行相一致。