一院多区护理区域协同与同质化管理模式

部队体制编制调整改革后,新组建医院呈现多城多区1+X模式,各院区间在资源配置、管理模式、职能任务和医疗水平上等参差不齐。医院借助信息化手段,协同院区间的优质资源,围绕同质化管理,标准化建设,规范化运行、差异化发展四个方面,统一组织管理架构和质量标准体系,建立人才培养长效机制。深度融合缩小区域间的差异,实现弹性调配资源共享,提升官兵不同院区间的就诊品质,有效促进一院多区护理工作的协同发展。     

植入前遗传学诊断研究进展

近年来 ,随着辅助生殖技术如体外受精 胚胎移植技术 ,显微操作技术如卵胞浆内单精子注射技术的发展 ,因其携带遗传性缺陷的风险和生殖细胞畸变的比率明显高于正常人群 ,故在此基础上发展了植入前遗传学诊断技术。目前 ,此项技术已在国内外各生殖中心迅速开展 ,现对其研究进展作一综述。     

兵器试验参与人员心理健康状况及影响因素

目的 调查兵器试验参与人员心理健康状况及影响因素,为制定干预对策、提高参与人员心理健康水平提供依据.方法 采用症状自评量表(SCL-90)、应激水平量表和访谈的方法,对某兵器试验单位390名参与人员心理健康特点及其影响因素进行调查与分析.结果 问卷结果显示,兵器试验参与人员SCL-90总分及躯体化、焦虑、强迫症状、人际关系敏感、抑郁、敌对因子分均明显高于非参与人员,差异有显著性(P＜0.05,P＜0.01).民主型管理方式、和睦的工作氛围和良好的人际关系中应激分数、SCL-90均分最低,差异有显著性(P＜0.05,P＜0.01).访谈显示,15名SCL-90得分较低的参与者认为,组织内部公平、在本单位有自豪感、信息公开透明、能够开放地讨论问题、得到同事和领导的尊重、个人才能得到发挥等条目所占百分比均高于另外15名SCL-90得分较高者,差异有显著性(P＜0.05).结论 兵器试验参与人员心理健康水平较非参与人员低,心理健康状况与工作环境、管理模式、工作氛围、人际关系等密切相关.     

家族性甲状腺髓样癌的遗传与临床研究

目的:调查一家系中甲状腺髓样癌(MTC)的发病情况与RET原癌基因突变与遗传的关系及临床意义。方法:提取21名家系成员外周血DNA。采用聚合酶链反应(PCR)及直接DNA测序技术,检测RET外显子突变状况,并检测该21名成员的血清降钙素、甲状旁腺素及癌胚抗原水平。结果:21名受检者中所有MTC患者7例及3例非MTC患者,检出RET第11外显子634位的tgc-tac突变。10名突变者中降钙素增高9例,甲状旁腺素增高8例,癌胚抗原增高6例。结论:FMTC具有明显遗传性,RET原癌基因11号外显子634位密码子(cys-tyr)突变是FMTC发病的分子生物学基础,检测RET原癌基因突变,结合血清降钙素,癌胚抗原和B超,有助于家系中高危人群的早期发现,早期治疗。     

Formation and Thermal Stability of the ω-Phase in Ti–Nb and Ti–Mo Alloys Subjected to HPT

This paper discusses the features of ω-phase formation and its thermal stability depending on the phase composition, alloying element and the grain size of the initial microstructure of Ti–Nb and Ti–Mo alloys subjected to high-pressure torsion (HPT) deformation. In the case of two-phase Ti–3wt.% Nb and Ti–20wt.% Nb alloys with different volume fractions of α- and β-phases, a complete β→ω phase transformation and partial α→ω transformation were found. The dependence of the α→ω transformation on the concentration of the alloying element was determined: the greater content of Nb in the α-phase, the lower the amount of ω-phase that was formed from it. In the case of single-phase Ti–Mo alloys, it was found that the amount of ω-phase formed from the coarse-grained β-phase of the Ti–18wt.% Mo alloy was less than the amount of the ω-phase formed from the fine α′-martensite of the Ti–2wt.% Mo alloy. This was despite the fact that the ω-phase is easier to form from the β-phase than from the α- or α′-phase. It is possible that the grain size of the microstructure also affected the phase transformation, namely, the fine martensitic plates more easily gain deformation and overcome the critical shear stresses necessary for the phase transformation. It was also found that the thermal stability of the ω-phase in the Ti–Nb and Ti–Mo alloys increased with the increasing concentration of Nb or Mo.     

大学语文中的人文精神教育探索

根据国家教委高教司对大学语文的定位,针对语文课程的性质、功能和大学生的实际状况,提出大学语文教学目标是培养、提高学生的人文精神、人文素养,传承中华民族优秀文化,并在教学实践中从文学的审美欣赏、情感教育,人格感染三个方面进行了一定的探索。     

Construction of a Dengue NanoLuc Reporter Virus for In Vivo Live Imaging in Mice

Since the first isolation in 1943, the dengue virus (DENV) has spread throughout the world, but effective antiviral drugs or vaccines are still not available. To provide a more stable reporter DENV for vaccine development and antiviral drug screening, we constructed a reporter DENV containing the NanoLuc reporter gene, which was inserted into the 5′ untranslated region and capsid junction region, enabling rapid virus rescue by in vitro ligation. In addition, we established a live imaging mouse model and found that the reporter virus maintained the neurovirulence of prototype DENV before engineering. DENV-4 exhibited dramatically increased neurovirulence following a glycosylation site-defective mutation in the envelope protein. Significant mice mortality with neurological onset symptoms was observed after intracranial infection of wild-type (WT) mice, thus providing a visualization tool for DENV virulence assessment. Using this model, DENV was detected in the intestinal tissues of WT mice after infection, suggesting that intestinal lymphoid tissues play an essential role in DENV pathogenesis.