首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   8929篇
  免费   1184篇
  国内免费   110篇
耳鼻咽喉   1346篇
儿科学   10篇
妇产科学   70篇
基础医学   349篇
口腔科学   5068篇
临床医学   270篇
内科学   266篇
皮肤病学   37篇
神经病学   179篇
特种医学   126篇
外科学   1106篇
综合类   492篇
预防医学   138篇
眼科学   413篇
药学   182篇
  3篇
中国医学   22篇
肿瘤学   146篇
  2024年   31篇
  2023年   213篇
  2022年   291篇
  2021年   470篇
  2020年   467篇
  2019年   533篇
  2018年   470篇
  2017年   494篇
  2016年   492篇
  2015年   526篇
  2014年   654篇
  2013年   880篇
  2012年   556篇
  2011年   500篇
  2010年   401篇
  2009年   404篇
  2008年   338篇
  2007年   348篇
  2006年   305篇
  2005年   281篇
  2004年   198篇
  2003年   189篇
  2002年   140篇
  2001年   127篇
  2000年   126篇
  1999年   107篇
  1998年   108篇
  1997年   82篇
  1996年   85篇
  1995年   59篇
  1994年   60篇
  1993年   46篇
  1992年   31篇
  1991年   25篇
  1990年   14篇
  1989年   9篇
  1988年   8篇
  1987年   15篇
  1986年   14篇
  1985年   26篇
  1984年   26篇
  1983年   20篇
  1982年   19篇
  1981年   11篇
  1980年   13篇
  1979年   2篇
  1978年   4篇
  1977年   2篇
  1976年   2篇
  1974年   1篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
远中移动磨牙技术的研究进展   总被引:3,自引:0,他引:3  
近年来不拔牙矫治重新得到正畸医生的重视,远中移动磨牙开拓间隙在临床上广泛应用,常用的推磨牙向远中方法有活动型、固定型、混合型以及近年来发展迅速的种植体支抗。本文对各种远中移动磨牙技术的进展进行综述。  相似文献   
993.
釉质瓷在人工种植牙中的应用   总被引:2,自引:0,他引:2  
为探索人工种植牙上部结构修复新途径,对40例人工植牙患者采用釉质瓷冠修复,一年后,复查成功率95%,与金属烤瓷相比,釉质瓷具操作简便,,负荷轻,硬度适中等优点,尤其适用于牙槽嵴吸收严重,种植体支持力不足患者。  相似文献   
994.
目的通过测试电子耳蜗植入患者电极分布频带颠倒排列前后声音识别的变化,探讨电极分布频带排列模式对声音识别能力的影响。方法15名电子耳蜗植入患者,分别依次测试电极分布频带颠倒排列前后对铃声(代表高频)和鼓声(代表低频)两种不同声音的识别能力,记录并分析结果。结果在电极分布频带按低频对应蜗尖、高频对应蜗底的正常顺序排列时,均能准确识别出铃声和鼓声。在电极分布频带颠倒排列后,13名受试者将铃声和鼓声均识别为鼓声,另2名则将铃声识别为鼓声,而将鼓声识别为铃声。结论电子耳蜗电极分布频带排列模式改变可以影响电子耳蜗植入患者对声音的识别能力。  相似文献   
995.

Objectives

The aim of this work was to compare different 12 cases (3 patients * 4 cases = 12 cases) with varying gaps between implant and bone by analyzing the effect of these gaps on implant and screws using FEM.

Methods

In each patient's case 1 using CSOG and in case 2, 3, and 4 without using CSOG tumor cutting was done. Hence in each patient zero gaps at case 1 and overcutting at case 2, 3, and 4 have obtained at different locations.

Results

FEM results reveal that in each patient's case 4 (maximum gap) was more susceptible to loosening of the screws due to higher strains (37%) and implant failure due to higher stress (28%) concentration under the same loading conditions when compared with case 1 (zero gap).

Conclusions

The study reveals that mandibular reconstruction with implant placement using CSOG can significantly enhance the stability and safety of the implant.  相似文献   
996.

Background

The OrthoMiDaS (Orthopedic Minimal Data Set) Episode of Care (OME) database was developed in an effort to advance orthopedic outcome measurements on a national scale. This study was designed to evaluate if the OME data capture system would increase the quality of data collected in the context of primary and revision total hip arthroplasty (THA) compared to conventional operative notes.

Methods

This study includes data from the first 100 primary THAs and 100 revision THAs performed by 15 surgeons at a single institution from January through April 2016. Surgeons prospectively entered procedural details into OME following surgery. The OME database and operative notes were compared to evaluate completion rates and agreement. Completion rates were compared using McNemar’s test (with continuity correction), while agreement was analyzed using Cohen’s kappa (κ) and concordance correlation coefficient.

Results

The OME database had significantly higher completion rates for 41% (39/96) of the variables. Proportion of data points that matched between the operative notes and OME data revealed that 54% (52/96) had a proportion agreement >0.90, and 79% (76/96) had a proportion agreement >0.80. In regard to measured agreement, 25% (24/96) of variables had almost perfect agreement, 29% (28/96) had substantial agreement, and 14% (13/96) had moderate agreement. Only 4% (4/96) had fair agreement, 8% (8/96) had slight agreement, and 6% (6/96) had poor agreement.

Conclusion

The OME data capture system is an efficient tool to document procedural details following THA. The system is user-friendly, comprehensive, and accurate. It has the potential to be a valuable tool for future orthopedic research.  相似文献   
997.

Background

Impacted bone allograft is used to restore lost bone in total joint arthroplasties. Bone morphogenetic proteins (BMPs) can induce new bone formation to improve allograft incorporation, but they simultaneously invoke a seemingly dose-dependent allograft resorption mediated by osteoclasts. Bisphosphonates effectively inhibit osteoclast activity. Predicting allograft resorption when augmented with bone morphogenetic protein 2 (BMP-2), we intended to investigate whether a balanced bone metabolism was achievable within a range of BMP-2 doses with systemic zoledronate treatment.

Methods

Implants were coated with 1 of 3 BMP-2 doses (15 μg, 60 μg, and 240 μg) or left untreated. Implants were surrounded by a 2.5-mm gap filled with impacted morselized allograft. Each of the 12 dogs included received 1 of each implant (15 μg, 60 μg, 240 μg, and untreated), 2 in each proximal humerus. During the 4-week observation period, zoledronate intravenous (0.1 mg/kg) was administered to all animals 10 days after surgery as anticatabolic treatment. Implant osseointegration was evaluated by histomorphometry and mechanical push-out tests.

Results

Untreated implants had the best mechanical fixation and superior retention of allograft as compared to any of the BMP-2 implants. Both mechanical implant fixation and retention of allograft decreased significantly with BMP-2 dose increments. Surprisingly, there was no difference among the treatment groups in the amount of new bone.

Conclusion

The use of BMP-2 to augment impaction-grafted implants cannot be recommended even when combined with systemic zoledronate.  相似文献   
998.
Purpose: Despite a substantial amount of literature on tissue-guided regeneration, decellularization process, repopulation time points and stem cell turnover, more in-depth study on the argument is required. Currently, there are plenty of reports involving large animals, as well as clinical studies facing cardiac repair with decellularized homografts, but no exhaustive rodent models are described. The purpose of this study was to develop such a model in rats; preliminary results are also herein reported. Material and Methods: Fresh or decellularized pulmonary homografts from wild type rats were implanted in the abdominal aorta of green fluorescent protein positive rats. Three experimental groups were build up: sham, fresh homograft recipients and decellularized homograft recipients. The homograft decellularization process was performed with three cycles of detergent-enzymatic treatment protocol. Surgical technique of pulmonary homograft implantation and postoperative ultrasonographic evaluation were also reported; gross, histology and immunohistochemistry analysis on unimplanted and postoperative homografts were also carried out. Results: The median total recipient operating time was 148 minutes, with a surgical success rate of 82%. The decellularization protocol resulted effective and showed a complete decellularization with intact extracellular matrix. At 15 days from surgery, the implanted decellularized pulmonary homografts exhibited cell repopulation in the outer media wall and partial endothelial lining in absence of rejection. Conclusions: Our technique is a feasible and reproducible model that can be fundamental for building a valid study for further exploitation on the field. Even in a short-term follow up, the decellularized pulmonary homografts showed autologous repopulation in absence of rejection.  相似文献   
999.
1000.
Additive manufacturing offers exciting new possibilities for improving long‐term metallic implant fixation in bone through enabling open porous structures for bony ingrowth. The aim of this research was to investigate how the technology could also improve initial fixation, a precursor to successful long‐term fixation. A new barbed fixation mechanism, relying on flexible struts was proposed and manufactured as a push‐fit peg. The technology was optimized using a synthetic bone model and compared with conventional press‐fit peg controls tested over a range of interference fits. Optimum designs, achieving maximum pull‐out force, were subsequently tested in a cadaveric femoral condyle model. The barbed fixation surface provided more than double the pull‐out force for less than a third of the insertion force compared to the best performing conventional press‐fit peg (p < 0.001). Indeed, it provided screw‐strength pull out from a push‐fit device (1,124 ± 146 N). This step change in implant fixation potential offers new capabilities for low profile, minimally invasive implant design, while providing new options to simplify surgery, allowing for one‐piece push‐fit components with high levels of initial stability. © 2017 The Authors. Journal of Orthopaedic Research® Published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 36:1508–1518, 2018.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号