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31.
In vitro characterization of peptide-modified p(AAm-co-EG/AAc) IPN-coated titanium implants. 总被引:1,自引:0,他引:1
Thomas A Barber Lara J Gamble David G Castner Kevin E Healy 《Journal of orthopaedic research》2006,24(7):1366-1376
Interpenetrating polymer networks (IPNs) of poly(acrylamide-co-ethylene glycol/acrylic acid) [p(AAm-co-EG/AAc)] functionalized with an -Arg-Gly-Asp- containing peptide derived from rat bone sialoprotein [bsp-RGD(15)] were grafted to titanium implants in an effort to modulate osteoblast behavior in vitro. Surface characterization data were consistent with the presence of an IPN, and ligand density measurements established that the range of peptide density on the modified implants spanned three orders of magnitude (0.01-20 pmol/cm2). In vitro biological characterization of the modified implants employing the primary rat calvarial osteoblast (RCO) model resulted in the identification of a critical ligand density (0.01implants compared to the base titanium and other control surfaces. The observed effects were attributed to specific interactions with bsp-RGD(15) and support the concept that peptide-modified implants can enhance the kinetics of differentiation of the cells they contact. These results suggest that in vivo biological performance evaluation of these biomimetic implant surfaces is merited. 相似文献
32.
一种新型人TNFα对人肝癌裸鼠移植瘤的抗瘤作用 总被引:1,自引:1,他引:0
用人肝癌Bel7402瘤株建立了人肝癌裸鼠移植瘤模型,探讨新型重组人TNFa对这种移植瘤的抗瘤作用,结果表明,rhTFaD11a和原型重组人TNFa的抑瘤率在30%左右时,后者后用的活性产闰数是前者的2倍;两者用量相同时,前者的抑产经比后者提高23个百分 相似文献
33.
34.
Pharmaceutical Research - 相似文献
35.
Summary The Bichat's fat pad (Corpus adiposum buccae) is of great significance in facial contouring. Resection of major parts of this fat pad results in hollow cheeks and in accentuation of the zygoma. On the other hand, hypoplasia or shrinkage of this fat pad can be augmented by means of silicone implants for improved aesthetic results. 相似文献
36.
目的探讨Medpor义眼座植入同期放置钛钉治疗眼球摘除术后眼眶凹陷畸形的有效性和可行性。方法眼球摘除同期置入Medpor义眼座患者80例,随机分为钛钉Ⅰ期置入组和Ⅱ期置入组,每组各40例。比较两组患者术中、术后出现的并发症和患者对义眼活动度和外观的满意程度。结果40例Ⅰ期置入患者术中有37例在术后2~6周时钛钉尾端自发性暴露,只有3例患者需要剪开结膜使钛钉尾端暴露。术后出现并发症者共37例,占46%:其中Ⅰ期置入组17例,Ⅱ期置入组加例,两者差异无统计学意义(P=0.501)。所有患者对其外观和活动度满意,其中Ⅰ期置入组非常满意36例,比较满意4例;Ⅱ期置入组非常满意34例,比较满意6例,两者差异无统计学意义(P=0.502)。结论Medpor义眼座置入同期放置钛钉治疗眼球摘除术后眼眶凹陷畸形,是一种安全有效的手术方法,同时患者避免了再次手术的痛苦。 相似文献
37.
本研究对钛种植体-羟基磷灰石(Ti-HA)在早期修复下颌骨缺损中与骨结合的界面形态进行了扫描电镜和X线能谱观察分析。通过对9只健康狗下颌骨缺损区植入Ti-HA2、6及12周后Ti-HA/宿主骨界面及Ti/HA界面的扫描电镜观察和X线能谱分析,结果表明Ti-HA植入骨缺损区,不引起正常的骨矿化过程改变,与宿主骨形成骨性结合;Ti/HA界面有新骨形成;扫描电镜观察和X线能谱分析在研究骨缺损修复过程中不同阶段的组织成份的变化是一个重要手段。 相似文献
38.
Bülent Erol MD Bars Kocaoglu MD Tanl Esemenli MD 《The Journal of foot and ankle surgery》2007,46(3):155-161
There are 2 main factors contributing to the strength of tendon repair: the tensile strength of the material used in repair and the tendon-holding capacity of the suture configuration. In the current study, we aimed to find a technique with high repair strength by increasing both the tensile strength of the material and the tendon-holding capacity of the configuration. We developed metal implants (models 1 and 2) made from stainless-steel wire with 2 different spiral-shaped configurations. We measured tendon-holding capacities of these alternative implants biomechanically and compared them with frequently used suture techniques, the Bunnell and locking loop, which were achieved with 5 Ticron sutures. Sixty-four sheep Achilles' tendons were used in the study as 16 tendons in each group. Model 2 was more resistant to deformation under loading when compared with model 1. The results demonstrated that model 2 was superior to model 1 and both suture techniques. This study could be accepted as a step for reaching a strong tendon repair technique. It should be emphasized that the technique needs to be improved technically to make it convenient for clinical use. 相似文献
39.
40.
Jennifer Tucker Ammon John Nyland Haw Chong Chang Robert Burden David N. M. Caborn 《Knee surgery, sports traumatology, arthroscopy》2007,15(11):1375-1381
This in vitro biomechanical study used cadaveric specimens to compare the rotator cuff repair fixation provided by BioCorkscrew
and Bioknotless RC suture anchors. Three cm wide by 1-cm long full-thickness supraspinatus defects were repaired using either
two BioCorkscrew suture anchors with combined vertical and horizontal mattress sutures (n = 7) or three Bioknotless RC suture anchors with simple sutures (n = 7). Therefore, the BioCorkscrew suture anchor group had two sutures per anchor (four total sutures), while the Bioknotless
RC suture anchor group had one suture per anchor (three total sutures). Two-phase cyclic (5–100 N, 1,000 cycles and 5–180 N,
2,000 cycles) and load to failure tests (31 mm/s) were performed. Non-parametric statistics were used to compare group differences
(P < 0.05). All of the BioCorkscrew group specimens (seven of seven) completed the two phase cyclic test regimen without failure
or gapping ≥ 5 mm, compared to only three of seven of the Bioknotless RC group (Fisher’s Exact test = 0.03). Groups did not
differ for repair site gapping during the 5–100 N cyclic test phase (Fisher’s Exact test = 0.77), however more of the Bioknotless
RC group displayed gapping ≥ 5 mm during the 5–180 N cyclic test phase than the BioCorkscrew group (P = 0.02). The BioCorkscrew group also displayed greater yield load during load to failure testing (492.2 ± 204 N vs. 296.4 ± 155 N,
P = 0.03). In this in vitro biomechanical study, the BioCorkscrew group with combined vertical and horizontal mattress sutures
displayed greater cyclic test survival, less repair site gapping, and superior yield load compared to the Bioknotless RC group
with simple sutures. These results in human cadaveric rotator cuff-humerus specimens suggest better immediate post-operative
repair site strength and a reduced need for post-operative restrictions. Clinical studies are needed to determine how these
rotator cuff repair modes withstand the forces of early rehabilitation and activities of daily living that potentially influence
patient outcomes. 相似文献