Expression of VEGF and VEGF-R3 receptor by placental endothelial cells in health and gestosis

We carried out a comparative analysis of changes in VEGF secretion and expression of VEGF-R3 receptor by placental endothelial cells in health and gestosis and of changes in VEGF-R3 expression by EA.hy926 human endothelial cells during culturing with supernatants conditioned by placental explants from women with normal pregnancy and patients with gestosis. Reduced secretion of VEGF and expression of VEGF-R3 by placental endothelial cells in gestosis can be caused by functional deficiency of the endothelial cells and low viability of endothelial cells. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 3, pp. 321–325, March, 2008     

Disorders in the Lungs-Placenta System under Conditions of Experimental Gestosis in Rats

Study of the arteriovenous difference in hormone levels and hemostasis parameters in rats with experimental gestosis induced by hypersodium diet showed decreased production of progesterone, increased level of hydrocortisone (resultant from its increased production and additional release of the hormone by the lungs), hypercoagulation, and retarded fetal development. Involvement of the lungs into the maintenance of optimum rheological parameters of arterial blood and a relationship between the level of fetoplacental hormones and the function of pulmonary fibrinolytic filter were detected. __________ Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 7, pp. 24–27, July, 2005     

妊娠高血压综合征视网膜病变的临床分析

目的：通过对115例妊娠高血压综合征（妊高征）患者进行眼底检查,了解妊高征患者视网膜病变的程度与妊高征的严重程度、高血压以及胎婴死亡率的关系。方法：比较妊高征的严重程度与视网膜病变程度的关系,和高血压与视网膜病变的关系,以及胎婴死亡率与视网膜病变严重程度的关系。结果：妊高征愈严重视网膜病变愈明显（P＜0．001）,血压愈高视网膜病变愈明显（P＜0．001）,视网膜病变愈严重提示胎婴死亡率愈高（P＜0．05）。结论：妊高征患者的眼底检查对指导临床治疗有重要的现实意义。     

Pharmacological Correction of Changes in the Lung—Placenta System under Experimental Conditions

Pathological changes in the fetoplacental complex and lung-placenta system were observed in rats with experimental gestosis produced by long-term feeding of a high-sodium diet. We revealed a decrease in the weights of the placenta and fetus, pulmonary fibrinolytic dysfunction, and increased production of cortisol. The course of fraxiparine treatment in animals with experimental gestosis decreased coagulation activity of the arterial blood, increased the weights of the placenta and fetus, and reduced the concentration of stress hormone cortisol. __________ Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 8, pp. 169–172, August, 2005