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排序方式: 共有9678条查询结果,搜索用时 15 毫秒
91.
Shunsuke Ohji Yosuke Kimura Yuhei Otobe Naohito Nishio Daisuke Ito Ryota Taguchi Hideyuki Ogawa Minoru Yamada 《The journal of spinal cord medicine》2021,44(2):262
Objective: Although the propulsion distance of a wheelchair is measured by some devices, measuring self-propulsion distance, excluding assistance propulsion distance by the caregiver, is difficult. This is a pilot study conducted to verify whether the propulsion distance of wheelchair users, excluding the assistance propulsion distance, can be measured using a cycle computer by attaching the touch switch.Methods: The wheelchair propulsion distance was measured using a cycle computer. We connected the touch switch and the cycle computer to the wheelchair to exclude assistance propulsion distance. We set the cycle computer to stop recording while the caregiver was touching the sensor. To confirm the propulsion distance using the cycle computer, the volunteer propelled the wheelchair on a rectangular facility with a total distance of 181 m, and the examiner confirmed the propulsion distance. The validation test to confirm the accuracy of the touch switch attached to the cycle computer was performed on a 50-m straight runway. The volunteer and caregiver propelled the wheelchair alternately by 10 m and continued until 50 m. The examiner confirmed the distance after 50-m propulsion.Results: In the 181-m rectangular facility, the propulsion distance that the volunteer propelled the wheelchair with the cycle computer was 180 m. In the 50-m straight runway, the propulsion distance was 30 m with caregiver assistance for 20 m.Conclusion: The present study showed that our modified device could measure the self-propulsion distance, excluding assistance propulsion distance in wheelchair users. 相似文献
92.
93.
ObjectiveTo assess whether patient socioeconomic status (SES) moderates the effectiveness of coordinated specialty care for first‐episode psychosis and to investigate possible mechanisms.Data SourcesA secondary analysis of data from the RAISE‐ETP Trial, which was conducted from 2010‐2014.Study DesignRAISE‐ETP was a cluster‐randomized trial comparing a coordinated specialty care (CSC) intervention called NAVIGATE with usual community care. We constructed a patient SES index based on parental education, parental occupational prestige, and race/ethnicity. After identifying correlates of SES, we used OLS regression analysis to estimate treatment effects on the major study outcomes across quartiles of the index. We also examined whether correlates of SES including the duration of untreated psychosis (DUP), and participation in NAVIGATE might account for the observed difference in effectiveness of CSC by SES.Principal FindingsThe trial sample had a similar SES distribution to the US population, and SES was positively correlated with all mental health outcomes and several potential moderators at baseline. CSC substantially improved the main trial outcomes compared to community care for patients in the highest SES quartile but had small and statistically insignificant benefits for the remaining 75% of patients. Intervention participation rates and several potential moderators did not explain this disparity.ConclusionsCSC may be more effective for high‐SES patients with early psychosis than low‐SES patients. Additional research is needed to understand why CSC is less effective for low‐SES patients and to develop methods to increase effectiveness for this subgroup. 相似文献
94.
Attallah AM Tabll AA El-Sadany M Ibrahim TA El-Dosoky I 《Clinical and experimental medicine》2003,3(3):181-185
Immunological factors are important in the pathogenesis of a wide spectrum of hepatobiliary diseases. Using flow cytometry, we determined the changes in lymphocyte subsets and natural killer cells in 123 individuals (81 patients with liver disease and 42 healthy volunteers). The liver diseases included periportal fibrosis (PPF, 10 patients), liver cirrhosis (LC, 31 patients), and hepatocellular carcinoma (HCC, 40 patients). Schistosomiasis and viral hepatitis B and C were the putative etiological agents of liver diseases. Immunophenotyping by indirect immunofluorescence was conducted using monoclonal antibodies to CD3 (T-lymphocytes), CD4 (helper/inducer T-cells), CD8 (suppressor/cytotoxic T-cells), and CD57 (natural killer cells) cell surface markers. Immunophenotyping of PPF patients showed no significant changes in all markers compared with the healthy controls. However, there was a significant decrease ( P<0.01) in CD3 and CD4 T-cells, and a highly significant increase ( P<0.001) in CD57 T-cells in patients with LC or HCC. In addition, LC and HCC patients showed no significant change in CD8 T-cells compared with controls. In conclusion, the progression of liver diseases is associated with a dysregulation of cellular immune responses. T-lymphocytes and natural killer cells may play a role in the immunopathogenesis of liver cirrhosis and HCC. 相似文献
95.
Fathy A. Khalifa 《Archives of pharmacal research》1990,13(2):198-200
3,4-Diphenyl-5-cyanopyridazin-6-one 3 was prepared from the reaction of cyano-acetamide2 with benzilhydrazone in dry pyridine. A series of its derivatives was prepared. Tolyl and benzene sulphonyl derivatives6a and6b are also prepared. 3,4-Diphenyl-5-cyano-pyridazin-6-thione5 was obtained from3 by the action of P2S5 while 3,4-diphenyl-5-cyano-6-chloropyridazine4 was obtained from3 by the action of POCl3. The reaction of4 with hydrazine hydrate directly afforded the pyrazolopyridazine derivative7. Compound4 also reacted with phenylhydrazine, aniline, thiophenol and anthranilic acid to yield pyridazine derivatives8, 9, 10 and11, respectively. On treatment of compound11 with acetic anhydride it cyclised to afford pyridazino pyrimidine derivatives12. 相似文献
96.
在讨论面向对象度量若干方法的基础上,着重介绍了一个关于度量C++代码的度量工具的设计和实现。 相似文献
97.
98.
Ping Gao Yinglin Lu Xueming Ge Wenhong Fan Shengfa Fu Shuang Liu Heping Yang 《中国癌症研究》1997,9(3):192-194
In order to investigate TGFβ1 gene expression and its effect on murine tumor growth following direct intratumoral injection
of naked plasmid DNA encoding human TGFβ1, LM3 murine lung adenocarcinoma cells were inoculated subcutaneously to T739 mice and grew to tumor nodules in 2 weeks. Multiple direct intratumoral injection of plasmid DNA, PMAMneo- TGFβ1, were given
and compared with saline or vector plasmid administration groups. The growth of tumor was observed till the 8th week when
the mice were killed for Northern blot analysis and histopathological study of tumoral tissue. The results showed that the
growth of tumor was boosted in the TGFβ1 gene treated mice as compared with the control groups, whereas there was no significant
difference in the metastatic behavior. Northern blot showed efficient expression of TGFβ1 mRNA in the treated group. The present
study indicated that TGFβ1 may stimulate tumor growthin vivo through certain mechanisms. And direct intra-tumoral injection of nude plasmid DNA may be a promising gene transfer strategyin vivo.
This work was supported by the National Natural Science Foundation of China (No. 39370761). 相似文献
99.
Vinicio Granados-Soto Marcelo de O. Rufino Lúcia D. Gomes Lopes Srgio H. Ferreira 《European journal of pharmacology》1997,340(2-3)
The effect of inhibition of nitric oxide synthesis and guanylate cyclase on the peripheral antinociceptive effect of morphine was assessed by using the formalin test in the rat. Saline, NG-monomethyl-
-arginine, a nitric oxide synthesis inhibitor (50 μg) and methylene blue, a guanylate cyclase inhibitor (500 μg), did not exhibit any antinociceptive activity. However, morphine (10 μg) produced a significant antinociceptive effect in phases 2a and 2b, which was reduced by pretreatment with either NG-monomethyl-
-arginine or methylene blue. These results suggest that the local administration of morphine induces antinociception by the activation of the
-arginine–nitric oxide–cGMP pathway. 相似文献
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100.
Christian Adam 《Zeitschrift fur Gesundheitswissenschaften》1997,5(1):4-13
In this essay national and international psychiatric-epidemiological studies on the subject of “depressive disorders in the elderly” are discussed. Although empirical case finding studies focused on in the essay have difficult problems to contend with, the attempt is made to systematize the prevalence and incidence rates of depressive disorders in the elderly population. The second part (publication in magazine 2/97) deals with the epidemiology of depressive disorders for the elderly. This article will present prevalence and incidence rates of depressive disorders in general and their depressive subtypes. 相似文献