全文获取类型
收费全文 | 4261篇 |
免费 | 375篇 |
国内免费 | 83篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 105篇 |
妇产科学 | 431篇 |
基础医学 | 668篇 |
口腔科学 | 47篇 |
临床医学 | 409篇 |
内科学 | 398篇 |
皮肤病学 | 42篇 |
神经病学 | 169篇 |
特种医学 | 220篇 |
外科学 | 229篇 |
综合类 | 445篇 |
预防医学 | 736篇 |
眼科学 | 20篇 |
药学 | 548篇 |
4篇 | |
中国医学 | 89篇 |
肿瘤学 | 148篇 |
出版年
2024年 | 8篇 |
2023年 | 62篇 |
2022年 | 91篇 |
2021年 | 153篇 |
2020年 | 133篇 |
2019年 | 124篇 |
2018年 | 145篇 |
2017年 | 136篇 |
2016年 | 145篇 |
2015年 | 177篇 |
2014年 | 238篇 |
2013年 | 317篇 |
2012年 | 208篇 |
2011年 | 231篇 |
2010年 | 185篇 |
2009年 | 186篇 |
2008年 | 190篇 |
2007年 | 187篇 |
2006年 | 172篇 |
2005年 | 149篇 |
2004年 | 120篇 |
2003年 | 103篇 |
2002年 | 126篇 |
2001年 | 86篇 |
2000年 | 76篇 |
1999年 | 77篇 |
1998年 | 88篇 |
1997年 | 89篇 |
1996年 | 69篇 |
1995年 | 70篇 |
1994年 | 77篇 |
1993年 | 54篇 |
1992年 | 48篇 |
1991年 | 43篇 |
1990年 | 38篇 |
1989年 | 38篇 |
1988年 | 45篇 |
1987年 | 41篇 |
1986年 | 22篇 |
1985年 | 49篇 |
1984年 | 30篇 |
1983年 | 13篇 |
1982年 | 16篇 |
1981年 | 14篇 |
1980年 | 11篇 |
1979年 | 7篇 |
1978年 | 8篇 |
1977年 | 8篇 |
1975年 | 5篇 |
1974年 | 3篇 |
排序方式: 共有4719条查询结果,搜索用时 15 毫秒
51.
52.
53.
54.
55.
《Seminars in Fetal & Neonatal Medicine》2022,27(1):101322
Neonatal diseases such as hypoxic ischemic encephalopathy, diseases of prematurity and congenital disorders carry increased morbidity and mortality. Despite technological advancements, their incidence remains largely unabated. Stem cell (SC) interventions are novel therapies in the neonatal world. In pre-clinical models of neonatal diseases, SC applications have shown encouraging results. SC sources vary, with the bone marrow being the most utilized. However, the ability to harvest bone marrow SCs from neonates is limited. Placental-tissue derived SCs (PTSCs), provide an alternative and highly attractive source. Human placentas, the cornerstone of fetal survival, are abundant with such cells. Comparing to adult pools, PTSCs exhibit increased potency, decreased immunogenicity and stronger anti-inflammatory effects. Several types of PTSCs have been identified, with mesenchymal stem cells being the most utilized population. This review will focus on PTSCs and their pre-clinical and clinical applications in neonatology. 相似文献
56.
目的:研究排卵期阴道脱落细胞的雌、孕激素受体。方法:自然排卵妇女、注射人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)促排卵妇女排卵期阴道脱落细胞,应用免疫组织化学ABC 法和图像分析技术进行雌激素受体(estrogenreceptor,ER) 和孕激素受体(progesteronereceptor,PR)的定位和定量研究。结果:两组组内排卵前、后阴道脱落细胞ER比较均无差异;注射hCG 后阴道脱落细胞的ER在排卵前和排卵后均较自然排卵组有明显增高;自然排卵组PR在排卵后较之排卵前明显升高。结论:排卵前后阴道上皮细胞ER 无明显变化;hCG可提高阴道上皮细胞ER 水平;排卵后阴道上皮细胞PR增加。 相似文献
57.
杨妍 《郑州大学学报(医学版)》1999,(1)
目的:了解郑州市中学生吸烟状况。方法:采用问卷法对6所中学4123名学生进行吸烟状况调查。结果:中学生总吸烟率为4516%(1862/4123)。其中,高中组吸烟率(5049%)高于初中组(3949%),男生吸烟率(7019%)明显高于女生(315%),且中学生吸烟的严重性随年龄的增加而增加;父母的文化程度、周围人群的吸烟情况与学生吸烟率有密切关系。结论:中学生吸烟问题较重,为保护中学生的身心健康应大力开展卫生宣教。 相似文献
58.
Pai Sudhakar M. Fettner Scott H. Hajian Gerald Cayen Mitchell N. Batra Vijay K. 《Pharmaceutical research》1996,13(9):1283-1290
Purpose. The objective of this work was to develop and validate blood sampling schemes for accurate AUC determination from a few samples (sparse sampling). This will enable AUC determination directly in toxicology studies, without the need to utilize a large number of animals.
Methods. Sparse sampling schemes were developed using plasma concentration-time (Cp-t) data in rats from toxicokinetic (TK) studies with the antiepileptic felbamate (F) and the antihistamine loratadine (L); Cp-t data at 13–16 time-points (N = 4 or 5 rats/time-point) were available for F, L and its active circulating metabolite descarboethoxyloratadine (DCL). AUCs were determined using the full profile and from 5 investigator designated time-points termed critical time-points. Using the bootstrap (re-sampling) technique, 1000 AUCs were computed by sampling (N = 2 rats/point, with replacement) from the 4 or 5 rats at each critical point. The data were subsequently modeled using PCNONLIN, and the parameters (ka, ke, and Vd) were perturbed by different degrees to simulate pharmacokinetic (PK) changes that may occur during a toxicology study due to enzyme induction/inhibition, etc. Finally, Monte Carlo simulations were performed with random noise (10 to 40%) applied to Cp-t and/or PK parameters to examine its impact on AUCs from sparse sampling.
Results. The 5 time-points with 2 rats/point accurately and precisely estimated the AUC for F, L and DCL; the deviation from the full profile was ~10%, with a precision (%CV) of ~15%. Further, altered kinetics and random noise had minimal impact on AUCs from sparse sampling.
Conclusions. Sparse sampling can accurately estimate AUCs and can be implemented in rodent toxicology studies to significantly reduce the number of animals for TK evaluations. The same principle is applicable to sparse sampling designs in other species used in safety assessments. 相似文献
59.
W. Zschiesche K. -H. Schaller D. Weltle 《International archives of occupational and environmental health》1992,64(1):13-23
Summary Soluble barium (Ba) compounds are well-known toxicants. Intoxications are mainly known in an acute form from casual or suicidal oral ingestion. No scientifically based data are available on possible health effects of inhalative exposure to soluble Ba salts at the workplace. Therefore, we investigated 18 welders in an interventional study over 1 week. They performed welding of Ba-containing stick electrodes and self-shielded flux cored wires under conditions similar to real working conditions. The welding fumes contained 31%–37% Ba, more than 90% of which was soluble in acids. Without appropriate preventive measures, a high rate of measurements exceeded the TLV values for total welding fumes of 5 mg/m3 and for soluble Ba of 0.5 mg/m3. The median fume concentrations were 13.2 mg/m3 in stick electrode welding and 12.3 mg/m3 in flux cored wire welding. The median Ba concentrations were 4.4 and 2.0 mg/m3 respectively. An integrated exhaust system built into the gun proved to be efficient in flux cored wire welding. The internal exposure to Ba reached median urine levels up to 101.7 g/l (normal: below 20 g/l) and median plasma concentrations of up to 24.7 g/l (normal: below 8 g/l). No health impact on the welders could be proven, but hypokalemia may have occurred as a result of the Ba exposure. 相似文献
60.