全文获取类型
收费全文 | 10284篇 |
免费 | 543篇 |
国内免费 | 352篇 |
专业分类
耳鼻咽喉 | 272篇 |
儿科学 | 278篇 |
妇产科学 | 128篇 |
基础医学 | 1059篇 |
口腔科学 | 206篇 |
临床医学 | 1273篇 |
内科学 | 1865篇 |
皮肤病学 | 467篇 |
神经病学 | 709篇 |
特种医学 | 366篇 |
外科学 | 842篇 |
综合类 | 1257篇 |
预防医学 | 945篇 |
眼科学 | 162篇 |
药学 | 1018篇 |
3篇 | |
中国医学 | 114篇 |
肿瘤学 | 215篇 |
出版年
2023年 | 94篇 |
2022年 | 268篇 |
2021年 | 309篇 |
2020年 | 309篇 |
2019年 | 326篇 |
2018年 | 311篇 |
2017年 | 250篇 |
2016年 | 298篇 |
2015年 | 314篇 |
2014年 | 528篇 |
2013年 | 802篇 |
2012年 | 462篇 |
2011年 | 556篇 |
2010年 | 486篇 |
2009年 | 516篇 |
2008年 | 522篇 |
2007年 | 485篇 |
2006年 | 424篇 |
2005年 | 383篇 |
2004年 | 321篇 |
2003年 | 304篇 |
2002年 | 284篇 |
2001年 | 228篇 |
2000年 | 184篇 |
1999年 | 192篇 |
1998年 | 163篇 |
1997年 | 173篇 |
1996年 | 130篇 |
1995年 | 143篇 |
1994年 | 133篇 |
1993年 | 130篇 |
1992年 | 113篇 |
1991年 | 113篇 |
1990年 | 112篇 |
1989年 | 119篇 |
1988年 | 96篇 |
1987年 | 85篇 |
1986年 | 73篇 |
1985年 | 57篇 |
1984年 | 68篇 |
1983年 | 40篇 |
1982年 | 31篇 |
1981年 | 26篇 |
1980年 | 35篇 |
1979年 | 36篇 |
1978年 | 24篇 |
1977年 | 30篇 |
1976年 | 23篇 |
1975年 | 26篇 |
1974年 | 15篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
We measured IgG antibody levels against eight different microbes in farmer's lung (FL) patients an average of 14 years after the first diagnosed episode of FL and in matched controls. The study population consisted of 87 FL patients and 81 control farmers, matched by age, sex, and smoking habits. Clinical studies included the measurement of IgG antibody levels against Absidia corymbifera, Aspergillus umbrosus, A. fumigatus, Humicola grisea, Saccharopolyspora rectivirgula, Penicillium brevicompactum, Rhodotorula glutinis, and Thermoactinomyces vulgaris, in addition to spirometry, pulmonary diffusing capacity (DL(CO)), and the evaluation of chronic bronchitis. Median IgG antibody levels were two or more times higher in FL patients than control farmers against Ab. corymbifera, S. rectivirgula, and T. vulgaris (P<0.001). Against A. fumigatus, H. grisea, and R. glutinis, FL patients also had significantly higher antibody levels. FL patients often had positive antibody titers against several microbes, whereas control farmers usually had a positive titer against one or two microbes. A positive association between IgG antibody levels and chronic bronchitis and DL(CO) was observed in FL patients, but not in control farmers. It is suggested that the high antibody levels noted in FL patients were due not only to high exposure but also to individual sensitivity to environmental microbes. 相似文献
82.
广州地区女性生殖道支原体感染及其药敏状况 总被引:2,自引:0,他引:2
目的: 了解广州地区女性生殖道支原体感染及药敏状况及其临床意义。方法:收集我院妇科门诊543 例宫颈分泌物标本进行支原体培养及药敏分析。结果:本院妇科门诊生殖道支原体感染率60.8% ;其中,解脲脲原体感染占68.9% ;新一代大环内酯类药及喹诺酮类药对解脲脲原体的敏感性较高;支原体混合感染可使其耐药性提高6~12 倍。结论:宫颈分泌物支原体阳性标本的药敏试验有助于本地区妇科门诊合理用药,减少盲目性。 相似文献
83.
目的探讨重度颅脑损伤病人康复期智力、记忆力及情感等方面的改变。②方法根据格拉斯哥昏迷指数(GCS)所规定的等级,对41例重度颅脑损伤病人进行智力、记忆力能力测验,并与我国常模比较。③结果康复优良组病人的操作智商、语言商数均在正常范围。重残组75.0%的病人语言商数明显降低,36.8%轻残组病人和100%重残病人操作智商降低。④结论严重颅脑损伤病人存在着智力、记忆力和情感障碍,重度残疾病人以操作智商降低为主,康复优良病人常出现智力与记忆力缺陷。 相似文献
84.
先天性胆总管囊肿并发肝功能异常的临床意义 总被引:1,自引:0,他引:1
目的 探讨先天性胆总管囊肿肝功能异常的病理基础及临床意义,方法 分析80例先天性胆总管囊肿患者的肝功能结果,对其中的36例进行肝病理观察及随访,结果 该病患儿肝功能异常的发生率为80%,胆汗淤滞是其病理基础,手术后随胆汁淤滞的解除,肝功能均恢复正常,结论 及时手术解除明道梗阻是改善肝功能的根本途径。 相似文献
85.
W. Grellner B. Madea J. P. Kruppenbacher S. Dimmeler 《International journal of legal medicine》1996,109(3):130-133
The phenomenon of artificially induced local leucocyte reactions during the supravital period could be of practical importance, but has not yet been comprehensively investigated. For a more detailed evaluation, experiments with the chemotactic agents interleukin-1 (IL-1) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) were performed by subcutaneous injection into various anatomical regions (back, abdomen, limbs) of NMRI-mice (National Medical Research Institute) and pigs 0–5 min after circulatory arrest. Phosphate buffered saline (PBS) without effective components was administered to equivalent areas of the animals as a control. Tissue specimens were collected at 6 h postmortem (mice) and 12–14 h postmortem (pigs), cut into serial sections, stained with H & E and examined under the microscope. A leucocyte reaction did not develop in pigs (n = 10, 30 tissue samples) following injection of FMLP, however, dermal, subcutaneous and perivascular infiltration of leucocytes (in particular mononuclear cells and a few granulocytes) was found in 3 out of 30 tissue specimens in murine experiments. In addition intravascular cell accumulations were detected in 2 out of 30 samples. The injection of IL-l to mice gave similar results, i.e. aggregations of leucocytes and intravascular cell accumulations in 4 out of 30 and 3 out of 30 tissue samples, respectively. In negative controls no leucocyte reaction was detectable. This shows that potent chemotactic factors such as IL-1 and FMLP administered in the early supravital period can induce moderate local leucocyte reactions in animal models in at least some cases. A clear morphological differentiation between vital and supravital chemotaxis does not seem to be possible. The supravitally stimulated accumulations of leucocytes are interpreted as an aggregation of resident macrophages in combination with a slight migration of blood leucocytes. Presumably, these alterations are restricted to the very early supravital period as long as sufficient energy reserves are available. It must be stated that the observed changes are reactions, not spontaneous actions, so that the general validity of the phenomenon of leucocyte infiltration as a vital parameter is not affected. 相似文献
86.
Evaluation of vesico-urethral and sweating function in disorders presenting with parkinsonism 总被引:1,自引:0,他引:1
Milena De Marinis Guido Argenta Domenico Mele Antonio Carbone Giulio Baffigo Alessandro Agnoli 《Clinical autonomic research》1993,3(2):125-130
Investigation of vesico-urethral and sweating function was performed in twelve patients with classical idiopathic Parkinson's disease and ten patients with parkinsonism associated with features suggestive of more extensive involvement of the nervous system, as in the Shy—Drager syndrome. The urodynamic studies revealed detrusor hyperreflexia with reduction of maximal cystometric capacity in only one patient with Parkinson's disease (8%), but in nine patients with parkinsonism associated with other features (90%). Urethral sphincter electromyography did not indicate denervation in any patient of either group. Delayed or incomplete relaxation of the urethral sphincter during micturition was observed in seven patients with Parkinson's disease (58%) and in two patients of the other group (20%). Decreased sweating responses were found in both groups of patients when compared with control subjects. Hypohidrosis was more pronounced in parkinsonism associated with other features than in Parkinson's disease. Differences in sweating between the two sides of the body were observed in both groups of patients. Although there are differences in vesico-urethral and sweating function, they do not precisely differentiate between patients with classical Parkinson's disease and those with parkinsonism associated with features suggestive of more extensive involvement of the nervous system. 相似文献
87.
88.
良性肺结节HRCT的影像特征 总被引:2,自引:0,他引:2
目的:用HRCT评价良性肺结节。方法:35例经手术病理或临床治愈证实的良性肺结节行HRCT扫描,观察其CT表现。结果:18例结核瘤中15例呈圆形或椭圆形,有长、短毛刺及环蛋壳状钙化者分别为13和14例,10例周围有纤维条索影或卫星播散病灶,7例增强扫描4例呈无强化,3例呈典型的包膜样强化。9例炎性假瘤均发生在两肺上叶前段或下叶基底段,6例结节呈圆形或类圆形,边缘可见长毛刺和胸膜凹陷征,3例周边可见斑片影及血管集束征,7例增强扫描6例呈良性肺结节的动态强化。3例错构瘤2例检出结节边缘砂粒样钙化和中央脂肪密度。2例肺脓肿均表现为圆形或类圆形中央低密度结节,增强扫描呈典型的周边环状强化。1例硬化性血管瘤周围可见受压小血管。1例肺霉菌球呈不规则形,有长毛刺及多个小空腔,周围有血管集束征及胸膜凹陷征。1例纤维瘤呈圆形,边缘光滑,密度均匀。结论:常见及少见良性肺结节进行HRCT扫描有助其定性诊断。 相似文献
89.
氧氟沙星加双黄连注射液静脉滴注致肝损害1例 总被引:1,自引:0,他引:1
任来春 《中国新药与临床杂志》2003,22(5):318-319
氧氟沙星 (ofloxacin)和双黄连 (Shuanghuangli an)已成为临床常用的抗菌药 ,但其不良反应亦不可忽视。我们曾遇见 1例用该 2药治疗上呼吸道感染引起严重肝功能损害 ,报道如下。病人男性 ,2 1a。主要因咽痛、咯痰、发热 2d入院。病人于入院前 2d出现咽痛、咯黄痰、胸痛、发热 (T38.9℃ )。诊断为上呼吸道感染。在当地卫生所给予氧氟沙星注射液(四川科伦大药厂生产 ,规格 :1 0 0mL :0 .2g批号 0 1 30 1 2 )0 .2g(1 0 0mL) +双黄连注射液 (齐齐哈尔第二制药厂生产 ,规格 :每支 2 0mL批号 30 0 1 32 ) 2 0… 相似文献
90.
In vitro tests for essential sperm functions using the phyto-oestrogen genistein as a test substance
Sperm motility, binding of spermatozoa to the zona pellucida and induction of the acrosome reaction are prerequisites for successful oocyte fertilization. Examination of the physiological and nonphysiological effects of particular compounds on sperm functions requires high-quality in vitro test systems. In this short methodological overview, a reliable combined in vitro test system with bovine gametes is described. The purpose of the study was to evaluate whether aliquots of pooled post-thaw spermatozoa are suitable for examination of environmental substances that affect essential sperm functions. The combined test system includes a number of known methods for the assessment of sperm vitality and motion parameters, acrosomal status, inducibility of acrosome reaction and sperm zona pellucida binding. First observations indicate that genistein inhibits the induction of acrosomal exocytosis and binding of spermatozoa to the zona pellucida. Motility parameters and the viability of bovine spermatozoa were not affected by this substance. It is concluded that genistein, a phyto-oestrogen which is abundant in several plants, can be used as a test substance for the evaluation of effects upon essential bovine sperm functions in vitro. 相似文献