经鼻给予抗ICAM-1抗体对大鼠脑缺血再灌注损伤的保护作用

目的 探讨经鼻腔给予抗细胞间黏附分子-1(ICAM-1)单克隆抗体(单抗)对大鼠脑缺血再灌注损伤的保护作用.方法 将30只雄性Wistar大鼠随机分为假手术组、脑缺血再灌注组及脑缺血再灌注+经鼻给予高、中、低剂量抗ICAM-1单抗干预组.采用插线法制作局灶脑缺血再灌注模型.各干预组于缺血1 h经鼻给予抗ICAM-1单抗,再灌24 h后取脑行冠状切片.采用TTC、HE及免疫组化染色法测定脑梗死体积及免疫组化阳性区占总面积比.结果 缺血再灌注组脑标本均可见缺血侧的脑膜充血,脑组织肿胀;单纯脑缺血再灌注组及低、中、高抗ICAM-1单抗干预组脑梗死体积(以像素值表示)分别为57 042±12 483、32 871±4 325、25 932±3 103和15 325±3 356,免疫组化阳性区面积占总面积比分别为(6.64±0.476)%、(5.15±0.987)%、(4.36±0.682)%和(3.42±0.537)%,各组间差异均有统计学意义.结论 (1)脑缺血再灌注可使脑组织ICAM-1表达显著增高;(2)经鼻腔给予抗ICAM-1单抗可有效降低脑组织ICAM-1的表达,缩小脑梗死体积;(3)经鼻腔给予抗ICAM-1单抗的剂量同脑梗死体积呈负相关;(4)脑缺血再灌注时ICAM-1免疫组化阳性区面积比与脑梗死体积呈正相关.     

Horizontal advancement flap for lateral dorsal nasal defects

BACKGROUND: Repairing dorsal nasal defects is a frequent challenge for dermatologic surgeons, mainly due to the high frequency of basal cell carcinomas on this site. Obvious scars, mismatched skin and distortion of the nasal contour are the surgical hazards that must be avoided in these cases. AIM: Our aim was to perform surgery involving a simple flap in order to repair medium to large defects on the dorsal side of the nose. METHODS: The dorsal horizontal advancement flap was studied in 12 patients, in order to evaluate the benefits and limits of this surgical procedure. RESULTS: The resulting scars on most of our patients were well-camouflaged among their natural skin lines, and there was neither distortion of the alar contour nor the nostril. CONCLUSIONS: This flap is easy to perform and, in selected cases, provides an outstanding alternative to second-intention healing, full-thickness skin grafts, transposition, rotation and pedicle flaps.     

鼻内镜下诊治鼻中隔骨折

目的:探讨鼻窦内镜对鼻中隔骨折的诊治。方法:45患者就诊时均行鼻窦内镜检查、鼻骨侧位片和鼻窦CT检查。均在鼻窦内镜下行鼻骨骨折复位术和鼻中隔成形术。结果:1例患者术后鼻外形改善不明显外,其余均得到治愈。结论:鼻窦内镜检查并酌行CT扫描是确诊鼻中隔骨折的主要手段,鼻骨骨折整复术同时可行鼻中隔成形术。     

药物传递系统（DDS）Ⅳ腔道给药传递系统

腔道给药是能起全身作用、避开肝首过代谢作用、患者便于自用的非损伤性给药途径。本文着重介绍影响鼻腔、阴道给药药物吸收的生物因素和剂型因素及正在开发的腔道给药传递系统。     

Acoustic rhinometry in pre-school children

Acoustic rhinometry was performed in 35 normal nose-breathing children between 3 and 6 years. The average cross-sectional areas at the nasal valve, at the anterior end of the turbinates, and in the nasopharynx were 0.34±0.06 cm², 0.35±0.08 cm² and 1.37±0.48 cm² respectively. The average minimal cross-sectional area was 0.29±0.06 cm². The minimal cross-sectional area was located at the nasal valve in 14 and at the anterior end of nasal tubinates in 21 of the 35 children. As would be expected, the cross-sectional areas at different sites of the nasal cavity increased with increasing age of the children. But, whereas the minimal cross-sectional area increased by 0.024 cm² per year, the nasopharyngeal cross-sectional area increased by 0.20 cm² per year. No significant differences were found between boys and girls. Measurements of the posterior nasal and nasopharyngeal cross-sectional areas were unreliable, whenever the minimal cross-sectional area was less than 0.2 cm². Furthermore, assessment of the nasopharynx may be difficult because of involuntary movements of the soft palate.     

Secondary correction of the unilateral cleft nose deformity with an endonasal technique

Summary Malposition of the nasal bone, septum and the alar cartilage are striking features of the unilateral cleft nose deformity. An endonasal technique (the extramucosal) was used in 26 patients, aged 13–38 (median 19), to correct aesthetic and functional problems. Twenty-four patients were secondary and two were tertiary. The patients were followed from 1–9 years. The pathological anatomy of the septum varied considerably, so different types of septoplasties had to be done. In 20 patients, satisfactory aesthetic and functional results were obtained in one operation. Secondary corrections were indicated in six patients. In cases with no gross scarring in or around the alar cartilage, the form and position of this cartilage will be more normal once the alar cartilages have been undermined and the deviation of the nasal bone and the septum is corrected.     

鼻内窥镜下鼻中隔矫正术

目的 :研究鼻内窥镜下鼻中隔矫正术的优点。方法 :鼻内窥镜下鼻中隔矫正术 5 0例 ,同期施行传统的鼻中隔矫正术 5 0例作为对照 ,分析两者手术时间、术中出血量及疼痛情况。结果 :鼻内窥镜组治愈率为96% ,手术时间 ( 35 .5 0± 5 .2 0 ) min,术中出血量 ( 2 3.2 2± 4.2 5 ) ml,疼痛发生率为 1 6% ;传统手术组治愈率为 90 % ,手术时间 ( 4 5 .64± 6.34) min,术中出血量 ( 31 .34± 5 .64) ml,疼痛发生率为 38%。经统计学分析两组治愈率差异无显著性 ( P>0 .0 5 ) ,鼻内窥镜组手术时间明显缩短 ( P<0 .0 1 ) ,术中出血量明显减少 ( P<0 .0 5 ) ,术中疼痛发生率明显降低 ( P<0 .0 5 )。结论 :鼻内窥镜下鼻中隔矫正术照明好 ,术野清晰 ,直视下手术 ,易剥离粘连处和及时发现粘膜损伤 ,手术时间短 ,术中出血量少 ,疼痛轻 ,术后并发症少 ,特别是鼻中隔矫正同期完成功能性鼻内窥镜手术及歪鼻矫正手术时更显示其优越性     

环糊精在鼻腔给药系统中的应用

综述了环糊精作为鼻腔给药系统赋形剂的应用及安全性.