全文获取类型
收费全文 | 12451篇 |
免费 | 1080篇 |
国内免费 | 525篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 148篇 |
妇产科学 | 107篇 |
基础医学 | 832篇 |
口腔科学 | 154篇 |
临床医学 | 1338篇 |
内科学 | 3271篇 |
皮肤病学 | 141篇 |
神经病学 | 412篇 |
特种医学 | 638篇 |
外国民族医学 | 1篇 |
外科学 | 878篇 |
综合类 | 1524篇 |
现状与发展 | 1篇 |
预防医学 | 589篇 |
眼科学 | 93篇 |
药学 | 1877篇 |
7篇 | |
中国医学 | 1594篇 |
肿瘤学 | 425篇 |
出版年
2024年 | 57篇 |
2023年 | 355篇 |
2022年 | 553篇 |
2021年 | 789篇 |
2020年 | 622篇 |
2019年 | 722篇 |
2018年 | 657篇 |
2017年 | 422篇 |
2016年 | 404篇 |
2015年 | 497篇 |
2014年 | 824篇 |
2013年 | 896篇 |
2012年 | 744篇 |
2011年 | 762篇 |
2010年 | 534篇 |
2009年 | 504篇 |
2008年 | 510篇 |
2007年 | 511篇 |
2006年 | 452篇 |
2005年 | 379篇 |
2004年 | 278篇 |
2003年 | 263篇 |
2002年 | 222篇 |
2001年 | 182篇 |
2000年 | 149篇 |
1999年 | 153篇 |
1998年 | 147篇 |
1997年 | 129篇 |
1996年 | 89篇 |
1995年 | 143篇 |
1994年 | 115篇 |
1993年 | 87篇 |
1992年 | 98篇 |
1991年 | 81篇 |
1990年 | 83篇 |
1989年 | 67篇 |
1988年 | 63篇 |
1987年 | 64篇 |
1986年 | 63篇 |
1985年 | 61篇 |
1984年 | 67篇 |
1983年 | 52篇 |
1982年 | 51篇 |
1981年 | 41篇 |
1980年 | 30篇 |
1979年 | 20篇 |
1978年 | 13篇 |
1977年 | 16篇 |
1976年 | 12篇 |
1975年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Matthew D. Li Katrina F. Chu Allegra DePietro Vincent Wu Eric Wehrenberg-Klee Omar Zurkiya Raymond W. Liu Suvranu Ganguli 《Journal of vascular and interventional radiology : JVIR》2019,30(3):314-319
Purpose
To evaluate the feasibility of a same-day yttrium-90 (90Y) radioembolization protocol with resin microspheres (including pretreatment angiography, lung shunt fraction [LSF] determination, and radioembolization) for the treatment of hepatocellular carcinoma (HCC) and liver metastases.Materials and Methods
All same-day radioembolization procedures performed over 1 y (February 2017 to January 2018) were included in this single-institutional retrospective analysis, in which 34 procedures were performed in 26 patients (median age, 63 y; 13 women), 19 with liver metastases and 7 with HCC. Yttrium-90 treatment activities were calculated by body surface area method. Tumor imaging response was assessed by Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 for liver metastases and modified RECIST for HCC. Clinical side effects and adverse events were graded per Common Terminology Criteria for Adverse Events version 4.0.Results
All planned cases were technically successful, and no cases were canceled for elevated LSF or vascular anatomic reasons. Pretreatment angiography modified the planned 90Y treatment activity in 1 case in which vascular anatomy required a lobar-dose split into 2 for segmental infusions. In 18% of cases, patients were briefly admitted after the procedure for observation or symptom management. Imaging evaluation of initial efficacy at 1 month demonstrated partial response in 25% and stable disease in 67% of patients with liver metastases and partial/complete response in 43% and stable disease in 14% of patients with HCC. Grade ≥ 3 adverse events occurred in 6% of cases, with no systemic therapy–limiting toxicities. The mean total procedure time was 4.2 hours.Conclusions
A same-day 90Y radioembolization protocol with resin microspheres is feasible in select patients, which can expedite cancer therapy. 相似文献22.
23.
《Journal of vascular and interventional radiology : JVIR》2020,31(7):1069-1073
This report describes a technique for measuring lung shunt fraction (LSF) twice in a single session during planning arteriography for radioembolization using low and standard dose technetium-99m macroaggregated albumin (99mTc-MAA). A patient with a 16.0 cm hepatocellular carcinoma and LSF of 70% was treated with lenvatinib for 4 weeks. Planning arteriography with administration of 0.5 millicuries of 99mTc-MAA was then performed. Arterial access was maintained while the LSF was calculated, which was persistently elevated at 54%. Embolization of arteriovenous shunts was performed during the same session and 5.0 millicuries of 99mTc-MAA were administered. The repeat LSF was 29%. Successful radioembolization was subsequently performed. 相似文献
24.
25.
26.
WT1基因位于人类染色体11p13,在80%的急性髓系白血病(acute myeloid leukemia,AML)患者中高表达,是AML预后不良的分子标志,可作为AML预后评估和微小残留病变(minimal residual disease,MRD)监测的有效指标。由于WT1在AML中均有异常高表达,故认为是一种AML抗原,可作为特异性免疫治疗的新靶点。一些小规模的临床试验证实以WT1为靶点的免疫治疗是有效的、安全的,这些免疫治疗可作为那些有高危复发风险及初始标准化疗失败的AML患者的辅助治疗。本文就近几年WT1与AML的预后及有关以WT1为靶点的主动特异性免疫治疗的研究进展予以综述。 相似文献
27.
An important part of fundamental research in catalysis is based on theoretical and modeling foundations which are closely connected with studies of single-crystalline catalyst surfaces. These so-called model catalysts are often prepared in the form of epitaxial thin films, and characterized using advanced material characterization techniques. This concept provides the fundamental understanding and the knowledge base needed to tailor the design of new heterogeneous catalysts with improved catalytic properties. The present contribution is devoted to development of a model catalyst system of CeO2 (ceria) on the Cu(111) substrate. We propose ways to experimentally characterize and control important parameters of the model catalyst—the coverage of the ceria layer, the influence of the Cu substrate, and the density of surface defects on ceria, particularly the density of step edges and the density and the ordering of the oxygen vacancies. The large spectrum of controlled parameters makes ceria on Cu(111) an interesting alternative to a more common model system ceria on Ru(0001) that has served numerous catalysis studies, mainly as a support for metal clusters. 相似文献
28.
主动呼吸控制技术(ABC)在肺癌放射治疗中的应用 总被引:1,自引:0,他引:1
目的:使用主动呼吸控制技术(aetive brething control,ABC)治疗非小细胞肺癌患者,评价呼吸运动时肺部肿瘤动度的影响及ABC技术的优势和可行性,并评价近期疗效和急性放射反应。方法:选择9例使用ABC技术联合三维造型放疗技术治疗的非小细胞系癌患者进行分析。CT定位扫描时分别采集ABC和自由呼吸(free breath.FB)状态下的图像,评价呼吸运动对肺部肿瘤动度和PTV边界的影响唾弃;并比较两种计划的DVH,放疗剂量为54-60Gy/18-20次。3Gy/次,1次/天,5天/周,定期随访,评价近期疗效及急性放射反应。结果:应用ABC技术后,隔肌的平均位移从FB时的43.5mm(20.0-32.0mm)降低为3.6mm(0.5-72.mm),胸壁的侧方位移从FB时的3.2mm(2.8-4.0mm)降低为1.2mm(0.5-1.6mm).PTV边界可以从FB时的1.5mm减少为0.75cm;肺的V20从21.8%降低为15.0%,减少了30.6%.中位随访6个月时,9例患者中有6例CR,3例PR.急性放射副反应都很轻微,仅为I-II.结论:在肺癌的精确放射治疗中,呼吸动度的影响不可忽视.而ABC系统可以有效的降低呼吸运动时治疗的影响,提高放疗的精确性,减少副反应.,但该系统使用较为复杂,延长了治疗的时间,个别患者不能忍受. 相似文献
29.
Jean-Pierre Bassand René Faivre Pascal Berthout Jean-Claude Cardot Josette Verdenet Roland Bidet Jean-Pierre Maurat 《European journal of nuclear medicine and molecular imaging》1987,13(8):419-424
The influence of left ventricular volume variations and regurgitant fraction variations upon left ventricular ejection fraction, during exercise was examined using equilibrium radionuclide angiography in patients suffering from aortic regurgitation. Ejection fraction (EF), regurgitant fraction (RF), end diastolic volume (EDV) and end systolic volume (ESV) variations from rest to peak exercise were determined in 44 patients suffering from chronic aortic regurgitation (AR) and in 8 healthy volunteers (C). In C, EF increased (+0.10±0.03, P<0.01) and ESV decreased significantly (-23%±12%, P<0.01) RF and EDV did not vary significantly. In AR patients, EF, EDV and ESV did not vary significantly because of important scattering of individual values. Changes in EF and ESV were inversely correlated (r=-0.79, P<0.01) and RF decreased significantly (-0.12±0.10, P<0.01). Volumes and EF changes during exercise occurred in three different ways. In a 1st subgroup of 7 patients, EF increased (+0.09±0.03, P<0.05) in conjunction with a reduction of ESV (-24%±12%, P<0.05) without a significant change in EDV. In a 2nd group of 22 patients. EF decreased (-0.04±0.07, P<0.01) in association with an increase in ESV (+17%±16%, P<0.01) and no change in EDV. In a 3rd subgroup of 15 patients, EF decreased (-0.02±0.06, P<0.01) despite a reduction in ESV (-7%±6%, P<0.01) because of a dramatic EDV decrease (-10%±6%, P<0.05). In this subgroup, changes in EF were inversely correlated with changes in ESV (r=-0.55, P<0.01) and positively related to EDV variations (r=0.42, P=0.02). EDV related to EDV variations (r=0.42, P=0.02). EDV changes were weakly, but significantly, correlated to RF decrease (r=0.39, P<0.05). We conclude that changes in left ventricular ejection fraction during exercise in patients with chronic aortic regurgitation are significantly related in some patients to changes in ventricular loading conditions as well as contractile state. Therefore, a correct interpretation of EF changes during exercise requires the simultaneous determination of changes in LV volumes.Abbreviations EDV
end diastolic volume
- EF
ejection fraction
- ESV
end systolic volume
- LV
left ventricle
- RV
right ventricle 相似文献
30.
大蒜素对脑局灶缺血大鼠血小板活化功能及其结构的影响 总被引:13,自引:0,他引:13
目的:观察大蒜素对脑局灶缺血大鼠血小板活化功能或轻药物诱导的血小板活化功能及其结构的影响。方法:(1)将SD大鼠随机分为(空白组、大蒜素大剂量组和小剂量组)3组,于末次给予试药1.5h后颈总动脉插管取血,加入诱导剂二磷酸腺苷(ADP)或胶原,测定血小板最大聚集率;(2)采用化学刺激(FeCl3)诱导血栓闭塞法制备大鼠急性大脑中动脉血栓模型,随机分为(假手术组、模型组、大蒜素大剂量组和小剂量组)4组,给药方法同实验(1),颈总动脉插管取血后分离血浆,测定血浆血栓烷B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)含量;(3)加入ADP孵育激活性,离心得到血小板沉淀块,透射电镜下观察血小板的超微结构。结果:与空白组或模型组相比,大蒜素大剂量组(10mg/kg)、小剂量组(5mg/kg)均可显著抑制药物诱导的血小板聚集(P<0.01),且大剂量组显著优于小剂量组(P<0.05);均可明显降低模型大鼠血浆TXB2的含量,降低TXB2/6-keto-PGF1α比值,大剂量组还显著升高血浆中6-keto-PGF1α水平(P<0.05,P<0.01);可明显抑制血小板活化过程中超微结构的改变,且有一定的量效关系。结论:大蒜素可能通过抑制血小板聚集,抑制血小板活化时大量释放的活性肽TXA2、促进恢复TXA2/PGI2平衡,抑制血小板激活释放过程中超微结构的改变,从而对脑梗塞起治疗作用。 相似文献